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Synthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP technique and examination of their antibacterial activity and cytotoxicity

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dc.contributor.authorSEZER, ALİ DEMİR
dc.contributor.authorsKaymaz, Aylin Pak; Acaroglu-Degitz, Ilayda; Yapaoz, Melda Altikatoglu; Sezer, Ali Demir; Malta, Seyda; Aksu, Burak; Eren, Tarik
dc.date.accessioned2022-03-12T22:38:25Z
dc.date.available2022-03-12T22:38:25Z
dc.date.issued2019
dc.description.abstractThis paper focuses on the synthesis of cationic antibacterial polymers that could be a potential source for new-generation antibiotics with well-defined architecture derived from the Ring Opening Metathesis Polymerization (ROMP) technique. Mono- and double-charge bearing quaternary groups have been used to synthesize cationic homopolymers (MWs: 3000 and 10,000 g/mole) and their copolymers (MWs: 5000 g/mole). Hemolytic concentration (HC50, >= 1000 mu g/mL) and MTS assay results showed that the polymers are non-toxic. It has been observed that the double-charge bearing polymers have the highest antimicrobial activity (S. aureus= 8 mu g/mL) and a high selectivity against S. aureus (>250). Percent killing efficiencies were tested on a glass surface where moderate killing efficiency was observed in the range of 40-80% in 5 min. Cationic charge density and zeta potential studies were used to investigate the mechanisms of antimicrobial efficiency of the polymers in a solution during the action against S. aureus to understand structure-activity relationships. Scanning electron microscopy (SEM) was also conducted for the bacterial morphology assay.
dc.identifier.doi10.1016/j.mtla.2019.100246
dc.identifier.issn2589-1529
dc.identifier.urihttps://hdl.handle.net/11424/235624
dc.identifier.wosWOS:000536259200074
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofMATERIALIA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectROMP
dc.subjectDABCO
dc.subjectPyridinium
dc.subjectHemolytic concentration
dc.subjectAntimicrobial activity
dc.subjectCationic polymer
dc.subjectOPENING METATHESIS POLYMERIZATION
dc.subjectANTIMICROBIAL POLYMERS
dc.subjectCHARGE-DENSITY
dc.subjectSURFACE
dc.subjectMIMICS
dc.titleSynthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP technique and examination of their antibacterial activity and cytotoxicity
dc.typearticle
dspace.entity.typePublication
local.avesis.idc7c5297e-b370-4859-8c64-d013979e2e8f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber100246
local.journal.numberofpages10
oaire.citation.titleMATERIALIA
oaire.citation.volume5
relation.isAuthorOfPublicationad927768-61be-404c-ab14-8887a0bd904f
relation.isAuthorOfPublication.latestForDiscoveryad927768-61be-404c-ab14-8887a0bd904f

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