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Effects of dapagliflozin in experimental sepsis model in rats

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dc.contributor.authorOKUYAN, BETÜL
dc.contributor.authorsKingir, Zehra Betul; Kumral, Zarife Nigar Ozdemir; Cam, Muhammet Emin; Cilingir, Ozlem Tugce; Sekerler, Turgut; Ercan, Feriha; Ozakpinar, Ozlem Bingol; Ozsavci, Derya; Sancar, Mesut; Okuyan, Betul
dc.date.accessioned2022-03-14T09:07:56Z
dc.date.available2022-03-14T09:07:56Z
dc.date.issued2018
dc.description.abstractBACKGROUND: The aim of this study was to evaluate the possible protective effects of dapagliflozin in an experimental sepsis model in rats. METHODS: Saline (1 mL/kg, p.o.) or dapagliflozin (10 mg/kg, p.o.) was administered to Sprague-Dawley rats for 5 days prior to the surgical procedures. Under anesthesia, sepsis was induced by cecal ligation puncture, while sham control groups underwent laparotomy only. Blood urea nitrogen, creatinine, and glucose levels were measured in serum samples and the levels of malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor alpha, interleukin 1 beta, caspase 8, and caspase 9 were determined in tissue samples (kidney, liver, and lung). Histological evaluation was also performed. RESULTS: The administration of dapagliflozin in a sepsis model reduced oxidative stress (MDA), increased antioxidant levels (GSH), and reduced inflammation (MPO) in the kidney (p<0.05). Dapagliflozin also decreased oxidative stress (MDA) in lung tissue and decreased inflammation (MPO) in lung and liver tissue (p<0.05). Caspase 8 and 9 levels in kidney, lung, and liver tissue were increased (p< 0.05) in the dapagliflozin group compared with the sepsis group. According to the histopathological results, sepsis was moderately improved in renal tissue and slightly attenuated in lung and liver tissue with the administration of dapagliflozin. CONCLUSION: Dapagliflozin had a preventive effect on sepsis-induced kidney damage, but the protective effect was mild in lung and liver tissue in the present study.
dc.identifier.doi10.5505/tjtes.2018.82826
dc.identifier.issn1306-696X
dc.identifier.pubmed31135951
dc.identifier.urihttps://hdl.handle.net/11424/242602
dc.identifier.wosWOS:000469248600002
dc.language.isoeng
dc.publisherTURKISH ASSOC TRAUMA EMERGENCY SURGERY
dc.relation.ispartofULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectdapagliflozin
dc.subjectinflammation
dc.subjectoxidative stress
dc.subjectsepsis
dc.subjectACUTE LUNG INJURY
dc.subjectNF-KAPPA-B
dc.subjectCECAL LIGATION
dc.subjectOXIDATIVE STRESS
dc.subjectSYSTEMIC INFLAMMATION
dc.subjectKIDNEY
dc.subjectPIOGLITAZONE
dc.subjectINHIBITION
dc.subjectPUNCTURE
dc.subjectGLUCOSE
dc.titleEffects of dapagliflozin in experimental sepsis model in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id24771c22-393c-4b09-ad20-2ecb734cbba3
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages9
local.journal.quartileQ4
oaire.citation.endPage221
oaire.citation.issue3
oaire.citation.startPage213
oaire.citation.titleULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
oaire.citation.volume25
relation.isAuthorOfPublicationf6e7969a-ea61-403f-8772-1a8478556223
relation.isAuthorOfPublication.latestForDiscoveryf6e7969a-ea61-403f-8772-1a8478556223

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