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Effects of apocynin against monosodium glutamate-induced oxidative damage in rat kidney

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsAÇIKEL ELMAS M., Ozgun G., Ozakpinar Ö., Guleken Z., ARBAK S.
dc.date.accessioned2023-08-14T12:12:15Z
dc.date.available2023-08-14T12:12:15Z
dc.date.issued2022-01-01
dc.description.abstractObjective: Monosodium glutamate causes oxidative stress that affects a variety of organ systems, along with the kidney. The aim of this study was to evaluate the protective role of apocynin in kidney degeneration caused by monosodium glutamate using biochemical and histological methods. Materials and Methods: Sprague-Dawley rats (n=32) were used for this study. Four experimental groups were randomly formed: the Control (Cont), Apocynin (APO), Monosodium Glutamate (MSG), and MSG+APO groups. The MSG group received oral administration of MSG (120 mg/kg) for 28 days. The MSG+APO and APO groups received apocynin (25 mg/kg) during the last 5 days of the experiment. Kidney tissue was processed for biochemical and microscopic analyses. Biochemical methods were used to examine the levels of malondialdehyde (MDA) and glutathione (GSH) in the tissue and the activities of myeloperoxidase (MPO) and superoxide dismutase (SOD). Light and electron microscopy were also used to examine for histological changes in kidney tissue. Results: The MSG group was compared with the Cont and APO groups; it was found that MDA and MPO levels were elevated, whereas GSH and SOD activity were decreased. In contrast to the Cont and APO groups, the MSG+APO group showed higher GSH levels, lower MPO activities and increased MDA levels. While apocynin treatment improved renal tissue histology, MSG-induction led to deterioration of renal morphology. Conclusion: The study revealed that MSG increased oxidative damage and renal tissue degeneration. Moreover, apocynin reduced renal damage by modulating the ratio of antioxidants to oxidants.
dc.identifier.citationAÇIKEL ELMAS M., Ozgun G., Ozakpinar Ö., Guleken Z., ARBAK S., "Effects of Apocynin against Monosodium Glutamate-Induced Oxidative Damage in Rat Kidney", European Journal of Biology, cilt.81, sa.2, ss.231-239, 2022
dc.identifier.doi10.26650/eurjbiol.2022.1148934
dc.identifier.endpage239
dc.identifier.issn2602-2575
dc.identifier.issue2
dc.identifier.startpage231
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146468439&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/292518
dc.identifier.volume81
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectHistology and Embryology
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectLife Sciences (LIFE)
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMICROBIOLOGY
dc.subjectCELL BIOLOGY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectMoleküler Biyoloji
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectHücre Biyolojisi
dc.subjectMolecular Biology
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectCell Biology
dc.subjectApocynin
dc.subjectGalectin
dc.subjectKidney
dc.subjectMonosodium glutamate
dc.subjectMonosodium glutamate
dc.subjectApocynin
dc.subjectKidney
dc.subjectGalectin
dc.titleEffects of apocynin against monosodium glutamate-induced oxidative damage in rat kidney
dc.typearticle
dspace.entity.typePublication
local.avesis.id88190278-c309-46d1-ad14-81caae09146c
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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