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Influence of multidrug resistant organisms on the outcome of diabetic foot infection

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dc.contributor.authorERTÜRK ŞENGEL, BUKET
dc.contributor.authorsSaltoglu, Nese; Ergonul, Onder; Tulek, Necla; Yemisen, Mucahit; Kadanali, Ayten; Karagoz, Gul; Batirel, Ayse; Ak, Oznur; Sonmezer, Cagla; Eraksoy, Haluk; Cagatay, Atahan; Surme, Serkan; Nemli, Salih A.; Demirdal, Tuna; Coskun, Omer; Ozturk, Derya; Ceran, Nurgul; Pehlivanoglu, Filiz; Sengoz, Gonul; Aslan, Turan; Akkoyunlul, Yasemin; Oncul, Oral; Ay, Hakan; Mulazimoglu, Lutfiye; Erturk, Buket; Yilmaz, Fatma; Yoruk, Gulsen; Uzun, Nuray; Simsek, Funda; Yildirmak, Taner; Yasar, Kadriye Kart; Sonmezoglu, Meral; kucukardali, Yasar; Tuna, Nazan; Karabay, Oguz; Ozgunes, Nail; Sargin, Fatma
dc.date.accessioned2022-03-14T09:03:45Z
dc.date.available2022-03-14T09:03:45Z
dc.date.issued2018-05
dc.description.abstractObjectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results: In total, 791 patients with DFI were included, 531(67%) were male, median age was 62 (19-90). Severe infection was diagnosed in 85 (11%) patients. Osteomyelitis was diagnosed in 291(36.8%) patients. 536 microorganisms were isolated, the most common microorganisms were S. aureus (20%), P. aeruginosa (19%) and E. coli (12%). Methicillin resistance (MR) rate among Staphylococcus aureus isolates was 31%. Multidrug resistant bacteria were detected in 21% of P. aeruginosa isolates. ESBL (+) Gram negative bacteria (GNB) was detected in 38% of E. coli and Klebsiella isolates. Sixty three patients (8%) were rehospitalized. Of the 791 patiens, 127 (16%) had major amputation, and 24 (3%) patients died. In multivariate analysis, significant predictors for fatality were; dialysis (OR: 8.3, Cl: 1.82-38.15, p = 0.006), isolation of Klebsiella spp. (OR:7.7, Cl: 1.24-47.96, p = 0.028), and chronic heart failure (OR: 3, Cl: 1.01-9.04, p = 0.05). MR Staphylococcus was detected in 21% of the rehospitalized patients, as the most common microorganism (p < 0.001). Conclusion: Among rehospitalized patients, methicillin resistant Staphylococcus infections was detected as the most common agent, and Klebsiella spp. infections were found to be significantly associated with fatality. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
dc.identifier.doi10.1016/j.ijid.2018.02.013
dc.identifier.eissn1878-3511
dc.identifier.issn1201-9712
dc.identifier.pubmed29476898
dc.identifier.urihttps://hdl.handle.net/11424/242321
dc.identifier.wosWOS:000432658100002
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetic foot infection
dc.subjectMRSA
dc.subjectKlebsiella
dc.subjectFatality
dc.subjectSOFT-TISSUE INFECTIONS
dc.subjectRISK-FACTORS
dc.subjectSTAPHYLOCOCCUS-AUREUS
dc.subjectANTIBIOTIC-THERAPY
dc.subjectULCERS
dc.subjectOSTEOMYELITIS
dc.subjectSOCIETY
dc.subjectIMPACT
dc.subjectTRIALS
dc.subjectTURKEY
dc.titleInfluence of multidrug resistant organisms on the outcome of diabetic foot infection
dc.typearticle
dspace.entity.typePublication
local.avesis.id605aad85-e07f-43f3-a84b-2a7a58a6e6f5
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ2
oaire.citation.endPage14
oaire.citation.startPage10
oaire.citation.titleINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
oaire.citation.volume70
relation.isAuthorOfPublication67d5b9df-08b7-4c37-b042-45ea89a4c23d
relation.isAuthorOfPublication.latestForDiscovery67d5b9df-08b7-4c37-b042-45ea89a4c23d

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