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Protective effects of vitamin E against hypercholesterolemia-induced age-related diseases

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsCatalgol, Betul; Ozer, Nesrin Kartal
dc.date.accessioned2022-03-14T09:53:53Z
dc.date.available2022-03-14T09:53:53Z
dc.date.issued2012-01
dc.description.abstractHypercholesterolemia is a major risk factor for age-related diseases such as atherosclerosis and Alzheimer's disease (AD). Changes in human plasma cholesterol levels results from the interaction between multiple genetic and environmental factors. The accumulation of excess cholesterol in blood vessels leads to atherosclerosis. Many studies on this field show that differential expression of oxidative stress-related proteins, lipid metabolism-related enzymes, and receptors response to atherogenic diet. Additionally, excess brain cholesterol has been associated with increased formation and deposition of amyloid-beta peptide from amyloid precursor protein which may contribute to the risk and pathogenesis of AD. To consider genetically, more than 50 genes have been reported to influence the risk of late-onset AD. Some of these genes might be also important in cholesterol metabolism and transport. Epidemiological studies have shown an association between high intake and high serum concentrations of antioxidant vitamins like vitamin E and lower rates of ischemic heart diseases. It has been known that vitamin E also inhibits smooth muscle cell proliferation by non-antioxidant mechanism. On the basis of the previous results, vitamin E has been accepted as an important protective factor against hypercholesterolemia-induced age-related diseases.
dc.identifier.doi10.1007/s12263-011-0235-9
dc.identifier.eissn1865-3499
dc.identifier.issn1555-8932
dc.identifier.pubmed21590435
dc.identifier.urihttps://hdl.handle.net/11424/243592
dc.identifier.wosWOS:000298808700011
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofGENES AND NUTRITION
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer's disease
dc.subjectAtherosclerosis
dc.subjectHypercholesterolemia
dc.subjectVitamin E
dc.subjectTocotrienol
dc.subjectPROTEIN-KINASE-C
dc.subjectINCREASED OXIDATIVE DAMAGE
dc.subjectSCAVENGER RECEPTOR EXPRESSION
dc.subjectDIETARY ANTIOXIDANT VITAMINS
dc.subjectCORONARY-HEART-DISEASE
dc.subjectRICH FRACTION TRF25
dc.subjectALPHA-TOCOPHEROL
dc.subjectALZHEIMERS-DISEASE
dc.subjectLIPID-PEROXIDATION
dc.subjectOXIDIZED LDL
dc.titleProtective effects of vitamin E against hypercholesterolemia-induced age-related diseases
dc.typearticle
dspace.entity.typePublication
local.avesis.idc654d72a-8f88-44d6-bfef-023074e60295
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage98
oaire.citation.issue1
oaire.citation.startPage91
oaire.citation.titleGENES AND NUTRITION
oaire.citation.volume7
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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