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Molecular Function of Tocopherols in Age Related Diseases

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsKarademir, Betul; Ozer, Nesrin Kartal
dc.date.accessioned2022-03-13T12:44:35Z
dc.date.available2022-03-13T12:44:35Z
dc.date.issued2014
dc.description.abstractTocopherols, with a phytyl side chain in its chroman ring, belong to vitamin E family and have several effects on organisms. They are also classified as therapeutics against different types of human diseases. Especially important roles in cell signaling and gene regulatory mechanisms make tocopherols crucial as therapeutic agents. Aging is accompanied with several degenerative disorders including cardiovascular, neuronal and metabolic diseases. The role of free radical damage in aging has been identified and tocopherols were shown to be involved in age related disorders. Recent studies and future directions will be focused in this review regarding the molecular functions of tocopherols.
dc.identifier.doi10.2174/13816128113196660707
dc.identifier.eissn1873-4286
dc.identifier.issn1381-6128
dc.identifier.pubmed24079766
dc.identifier.urihttps://hdl.handle.net/11424/237580
dc.identifier.wosWOS:000336792400006
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT PHARMACEUTICAL DESIGN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTocopherol
dc.subjectaging
dc.subjectatherosclerosis
dc.subjectAlzheimer's disease
dc.subjectnonalcoholic fatty liver disease
dc.subjectFATTY LIVER-DISEASE
dc.subjectSCAVENGER RECEPTOR EXPRESSION
dc.subjectVITAMIN-E CONSUMPTION
dc.subjectSMOOTH-MUSCLE-CELLS
dc.subjectD-ALPHA-TOCOPHEROL
dc.subjectKINASE-C-ALPHA
dc.subjectALZHEIMERS-DISEASE
dc.subjectOXIDATIVE STRESS
dc.subjectNONALCOHOLIC STEATOHEPATITIS
dc.subjectTRANSFER PROTEIN
dc.titleMolecular Function of Tocopherols in Age Related Diseases
dc.typearticle
dspace.entity.typePublication
local.avesis.idd314dc2c-6534-42c6-8e58-c0a73b79a17a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage3035
oaire.citation.issue18
oaire.citation.startPage3030
oaire.citation.titleCURRENT PHARMACEUTICAL DESIGN
oaire.citation.volume20
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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