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Immunohistochemical expression of plasminogen activator inhibitor-1 in subcutaneous versus omental adipose tissue in patients after elective abdominal surgery

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dc.contributor.authorBOZKURTLAR, EMİNE
dc.contributor.authorsYildiz, Mehmet; Bozkurtlar, Emine; Azizy, Abdulmunir; Agirbasli, Mehmet
dc.date.accessioned2022-03-14T04:29:55Z
dc.date.available2022-03-14T04:29:55Z
dc.date.issued2019
dc.description.abstractPlasminogen activator inhibitor-1 (PAI-1) is a biomarker of thrombosis. Adipose and vascular tissues are among the major sources of PAI-1 production. Previous studies indicated that fat deposits mediate increased cardiovascular risk among obese individuals. We investigated the immunohistochemical (IHC) expression of PAI-1 in adipose and vascular tissues from the omentum and the subcutaneous tissue. The pathology samples were selected from 37 random patients who underwent elective abdominal surgery between 2008-2009. PAI-1 expression was semi-quantitatively scored and compared between the groups. Significant differences were noted in the IHC expression of PAI-1 between the omental and the subcutaneous adipose tissues (1.1 ± 0.8 versus 0.8 ± 0.6, respectively (p=0.05)). Adipose tissue displayed higher IHC expression of PAI-1 compared to vascular wall tissue in both omentum and subcutaneous sections (1.1 ± 0.8 versus 0.5 ± 0.9 (p=0.004), and 0.8 ± 0.6 versus 0.4 ± 0.6 (p=0.003), respectively). In conclusion, our study compared PAI-1 expression in the omentum versus the subcutaneous tissue and adipose versus vascular tissues. IHC expression of PAI-1 level was significantly higher in the omental adipose tissue compared to the subcutaneous adipose tissue. Adipose tissue displayed significantly higher PAI-1 expression than vascular tissue. The study elucidates the biological differences of adipose and vascular tissue from subcutaneous versus omental sections.
dc.identifier.doi10.4322/acr.2019.121
dc.identifier.issn2236-1960
dc.identifier.pubmedPMID: 31641662 PMCID: PMC6771447
dc.identifier.urihttps://hdl.handle.net/11424/238870
dc.language.isoeng
dc.relation.ispartofAutopsy & Case Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectImmunohistochemistry
dc.subjectAdipose Tissue
dc.subjectPlasminogen Activator Inhibitor-1
dc.titleImmunohistochemical expression of plasminogen activator inhibitor-1 in subcutaneous versus omental adipose tissue in patients after elective abdominal surgery
dc.typearticle
dspace.entity.typePublication
local.avesis.id1622b1fe-29e3-4185-989d-9e3700a1cf16
local.import.packageSS18
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.startPagee2019121
oaire.citation.titleAutopsy & Case Reports
oaire.citation.volume4
relation.isAuthorOfPublication2343a71e-12cf-42ea-89ed-b222d121f733
relation.isAuthorOfPublication.latestForDiscovery2343a71e-12cf-42ea-89ed-b222d121f733

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