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Levan-based hydrogels for controlled release of Amphotericin B for dermal local antifungal therapy of Candidiasis

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dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsDemirci, Tuba; Haskoylu, Merve Erginer; Eroglu, Mehmet Sayip; Hemberger, Jurgen; Oner, Ebru Toksoy
dc.date.accessioned2022-03-12T22:43:10Z
dc.date.available2022-03-12T22:43:10Z
dc.date.issued2020
dc.description.abstractHydrogels from Halomonas levan polysaccharide were prepared at different crosslinking densities. Swelling results demonstrated pH dependent rather than temperature dependent swelling of the hydrogel and the highest swelling value was achieved at basic conditions with a swelling ratio of 9.1 +/- 0.1 which is the highest reported for levan based hydrogels. SEM images show a porous network architecture, which indicates a large surface area of the hydrogels. Rheological analyses showed the viscoelastic behavior of the hydrogels. Biocompatibility of the hydrogels was confirmed by cell culture experiments. For drug release experiments Amphotericin B (AmB) was used. 51% of the loaded AmB was released into the PBS buffer and the released AmB had a significant antifungal activity against Candida albicans.
dc.identifier.doi10.1016/j.ejps.2020.105255
dc.identifier.eissn1879-0720
dc.identifier.issn0928-0987
dc.identifier.pubmed32032777
dc.identifier.urihttps://hdl.handle.net/11424/236299
dc.identifier.wosWOS:000519528400010
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHalomonas Levan
dc.subjectHydrogel
dc.subjectAmphotericin B
dc.subjectControlled drug release
dc.subjectAntifungal activity
dc.subjectWound healing
dc.subjectHALOMONAS-SMYRNENSIS
dc.subjectSILVER NANOPARTICLES
dc.subjectCOMPLEXATION
dc.subjectBINDING
dc.subjectSYSTEM
dc.subjectFILMS
dc.subjectGEL
dc.titleLevan-based hydrogels for controlled release of Amphotericin B for dermal local antifungal therapy of Candidiasis
dc.typearticle
dspace.entity.typePublication
local.avesis.id0d0d037d-2505-4920-b487-cca316b2fac7
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber105255
local.journal.numberofpages10
local.journal.quartileQ2
oaire.citation.titleEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
oaire.citation.volume145
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery6118e9e4-a58e-429b-bbec-4f73a3089a2b

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