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Predictive factors for the development of brain metastases in patients with malignant melanoma: a study by the Anatolian society of medical oncology

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dc.contributor.authorDANE, FAYSAL
dc.contributor.authorsGumusay, Ozge; Coskun, Ugur; Akman, Tulay; Ekinci, Ahmet Siyar; Kocar, Muharrem; Erceleb, Ozlem Balvan; Yazici, Ozan; Kaplan, Mehmet Ali; Berk, Veli; Cetin, Bulent; Taskoylu, Burcu Yapar; Yildiz, Ayhan; Goksel, Gamze; Alacacioglu, Ahmet; Demirci, Umut; Algin, Efnan; Uysal, Mukremin; Oztop, Ilhan; Oksuzoglu, Berna; Dane, Faysal; Gumus, Mahmut; Buyukberber, Suleyman
dc.date.accessioned2022-03-13T12:46:56Z
dc.date.available2022-03-13T12:46:56Z
dc.date.issued2014
dc.description.abstractThe development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of < 6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify factors predicting development of BMs and survival. We performed a retrospective analysis of 470 melanoma patients between 2000 and 2012. The logistic regression analyses were used to identify the clinicopathological features of primary melanoma that are predictive of BMs development and survival after a diagnosis of brain metastases. There were 52 patients (11.1 %) who developed melanoma BMs during the study period. The analysis of post-BMs with Kaplan-Meier curves has resulted in a median survival rate of 4.1 months (range 2.9-5.1 months). On logistic regression analysis site of the primary tumor on the head and neck (p = 0.002), primary tumor thickness (Breslow > 4 mm) (p = 0.008), ulceration (p = 0.007), and pathologically N2 and N3 diseases (p = 0.001) were found to be significantly associated with the development of BMs. In univariate analysis, tumor thickness and performance status had a significant influence on post-BMs survival. In multivariate analysis, these clinicopathologic factors were not remained as significant predictive factors. Our results revealed the importance of primary tumor characteristics associated with the development of BMs. Ulceration, primary tumor thickness, anatomic site, and pathologic a parts per thousand yenN2 disease were found to be significant predictors of BMs development.
dc.identifier.doi10.1007/s00432-013-1553-7
dc.identifier.eissn1432-1335
dc.identifier.issn0171-5216
dc.identifier.pubmed24292400
dc.identifier.urihttps://hdl.handle.net/11424/238000
dc.identifier.wosWOS:000329236800017
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMelanoma
dc.subjectBrain metastases
dc.subjectPredictive factors
dc.subjectCENTRAL-NERVOUS-SYSTEM
dc.subjectCEREBRAL METASTASES
dc.subjectCUTANEOUS MELANOMA
dc.subjectPROGNOSTIC-FACTORS
dc.subjectTHERAPY
dc.subjectSURVIVAL
dc.subjectLYMPHADENECTOMY
dc.subjectFEATURES
dc.subjectTRIAL
dc.subjectSTAGE
dc.titlePredictive factors for the development of brain metastases in patients with malignant melanoma: a study by the Anatolian society of medical oncology
dc.typearticle
dspace.entity.typePublication
local.avesis.id3e4a5caa-f909-4545-837f-1179c18105af
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
oaire.citation.endPage157
oaire.citation.issue1
oaire.citation.startPage151
oaire.citation.titleJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
oaire.citation.volume140
relation.isAuthorOfPublication059ce50a-8d16-4fc6-a86c-85c9baa19a5c
relation.isAuthorOfPublication.latestForDiscovery059ce50a-8d16-4fc6-a86c-85c9baa19a5c

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