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Apocrine carcinomas of the breast in Turkish women: Hormone receptors, c-erbB-2 and p53 immunoexpression

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dc.contributor.authorKAYA, HANDAN
dc.contributor.authorsKaya, Handan; Bozkurt, Sueheyla Uyar; Erbarut, Ipek; Djamgoz, Mustafa B. A.
dc.date.accessioned2022-03-12T17:34:11Z
dc.date.available2022-03-12T17:34:11Z
dc.date.issued2008
dc.description.abstractThe aims of this study were twofold: (i) to determine the occurrence frequency of apocrine carcinoma of the breast (ApBCa) in Turkish breast cancer (BCa) patients; and (ii) to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), gross cystic disease protein-15 (GCDFP-15), c-erbB-2, and p53 in these cases. Six hundred and twenty-six cases of BCa were studied immunohistochemically (streptoavidin-biotin horseradish peroxidase method). The results of ApBCa were compared with those of invasive ductal carcinoma not otherwise specified type (IDC-NOS) cases of similar grade. Thirteen cases of ApBCa were encountered, accounting for 2.1% of all BCa cases. Immunohistochemically, ApBCa positivity was as follows: GCDFP-15 (100%), ER (39%), PR (8%), AR (54%), p53 (39%), and c-erbB-2 (85%). In the IDC-NOS group, GCDFP-15* was expressed in less than 50% of the tumors. The occurrence frequencies of the other markers were as follows: ER (69%), PR (69%)*, AR (46%), c-erbB-2 (0%)*, and p53 (31%), (*) indicating significant differences between the two groups. For Turkish BCa patients, (i) the occurrence rate of ApBCa (2.1%) was high; and (ii) the following combination would allow for an immunohistochemical identification of ApBCa: GCDFP-15(+), c-erbB-2(+), and PR-. (C) 2008 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.prp.2008.01.012
dc.identifier.issn0344-0338
dc.identifier.pubmed18342452
dc.identifier.urihttps://hdl.handle.net/11424/228981
dc.identifier.wosWOS:000257025500002
dc.language.isoeng
dc.publisherELSEVIER GMBH
dc.relation.ispartofPATHOLOGY RESEARCH AND PRACTICE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectapocrine carcinoma
dc.subjectbreast
dc.subjecthormone receptor
dc.subjectoncogene
dc.subjectPROGESTERONE-RECEPTOR
dc.subjectESTROGEN-RECEPTOR
dc.subjectIMMUNOHISTOCHEMICAL ANALYSIS
dc.subjectANDROGEN RECEPTORS
dc.subjectEXPRESSION
dc.subjectMUTATIONS
dc.subjectFREQUENCY
dc.subjectPATHOLOGY
dc.subjectCANCER
dc.subjectAGE
dc.titleApocrine carcinomas of the breast in Turkish women: Hormone receptors, c-erbB-2 and p53 immunoexpression
dc.typearticle
dspace.entity.typePublication
local.avesis.id0e4e4e6a-75af-497c-bb0a-c486cb54c2ed
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage371
oaire.citation.issue6
oaire.citation.startPage367
oaire.citation.titlePATHOLOGY RESEARCH AND PRACTICE
oaire.citation.volume204
relation.isAuthorOfPublication0bf301ff-2544-4a5e-b38b-b43084d6c255
relation.isAuthorOfPublication.latestForDiscovery0bf301ff-2544-4a5e-b38b-b43084d6c255

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