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Dual effect of procaine-loaded pectin hydrogels: pain management and in vitro wound healing

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dc.contributor.authorBATIREL, SAİME
dc.contributor.authorsRodoplu, Seniz; Celik, Bengi Ezgi; Kocaaga, Banu; Ozturk, Cenk; Batirel, Saime; Turan, Deniz; Guner, F. Seniha
dc.date.accessioned2022-03-12T22:42:44Z
dc.date.available2022-03-12T22:42:44Z
dc.date.issued2021
dc.description.abstractThis study aims to develop procaine-loaded pectin hydrogels for both local anesthetic delivery and wound healing. We investigated the effects of initial drug concentration, pH of initial drug solution, and drying temperature of hydrogel on the drug release behavior of hydrogels. Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy were used for their characterization. Their swelling percentage, drug loading, and drug release behaviors were determined. Toxic effects of selected hydrogels on the wound healing ability of PCS-201-012 human dermal fibroblast cells and wound dressing properties were also investigated. According to our results, the hydrogels did not affect cell migration. Initial drug concentration, pH of initial drug solution, and drying temperature of hydrogels are crucial on procaine release behavior of pectin-based hydrogels.
dc.identifier.doi10.1007/s00289-020-03210-7
dc.identifier.eissn1436-2449
dc.identifier.issn0170-0839
dc.identifier.urihttps://hdl.handle.net/11424/236256
dc.identifier.wosWOS:000529767300001
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofPOLYMER BULLETIN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLocal anesthetic
dc.subjectPectin hydrogel
dc.subjectProcaine
dc.subjectWound dressing
dc.subjectLOCAL-ANESTHETICS
dc.subjectCONTROLLED-RELEASE
dc.subjectDRUG-RELEASE
dc.subjectALGINATE
dc.subjectDELIVERY
dc.subjectANTIBACTERIAL
dc.subjectPH
dc.subjectHYDROCHLORIDE
dc.subjectLIDOCAINE
dc.subjectFILMS
dc.titleDual effect of procaine-loaded pectin hydrogels: pain management and in vitro wound healing
dc.typearticle
dspace.entity.typePublication
local.avesis.id976e2fe8-49e3-44a5-8eee-8f89f7127656
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages24
local.journal.quartileQ2
oaire.citation.endPage2250
oaire.citation.issue4
oaire.citation.startPage2227
oaire.citation.titlePOLYMER BULLETIN
oaire.citation.volume78
relation.isAuthorOfPublication819f23bf-7f20-4c27-95c0-15d1a199b19d
relation.isAuthorOfPublication.latestForDiscovery819f23bf-7f20-4c27-95c0-15d1a199b19d

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