Publication:
Recent Progress on Apoptotic Activity of Triazoles

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dc.contributor.authorSÜZGÜN, PELİN
dc.contributor.authorsCikla-Suzgun, P.; Kucukguzel, S. G.
dc.date.accessioned2022-03-10T15:25:45Z
dc.date.available2022-03-10T15:25:45Z
dc.date.issued2021
dc.description.abstractApoptosis is often called programmed cell death and is defined as a self-directed cell destruction process. It is different from necrosis due to the activation of caspases during this process. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotoxic drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5 membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic activities. The present review describes recent medicinal aspects of triazoles as anticancer agents that have been reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of a new generation of small molecule drugs.
dc.identifier.doi10.2174/1389450122666210208181128
dc.identifier.eissn1873-5592
dc.identifier.issn1389-4501
dc.identifier.pubmed33563153
dc.identifier.urihttps://hdl.handle.net/11424/220350
dc.identifier.wosWOS:000711465400004
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT DRUG TARGETS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjecttriazole
dc.subjectcancer
dc.subjectcaspase-8
dc.subjectcaspase-3
dc.subjectBcl-2
dc.subjectcytochrome C
dc.subjectHEAT-SHOCK FACTOR-1
dc.subjectBIOLOGICAL EVALUATION
dc.subjectANTICANCER ACTIVITY
dc.subjectCANCER-CELLS
dc.subjectANTITUMOR-ACTIVITY
dc.subjectBETULINIC ACID
dc.subjectLUNG-CANCER
dc.subjectAROMATASE INHIBITORS
dc.subjectCYTOTOXIC ACTIVITY
dc.subjectCARCINOMA CELLS
dc.titleRecent Progress on Apoptotic Activity of Triazoles
dc.typereview
dspace.entity.typePublication
local.avesis.idc0dc8daa-ad37-4f1f-9e0f-fe0d7c49b713
local.import.packageSS5
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.numberofpages57
oaire.citation.endPage1900
oaire.citation.issue16
oaire.citation.startPage1844
oaire.citation.titleCURRENT DRUG TARGETS
oaire.citation.volume22
relation.isAuthorOfPublication6f8a150f-0ec8-4a51-9a1b-b9c26aecdf69
relation.isAuthorOfPublication.latestForDiscovery6f8a150f-0ec8-4a51-9a1b-b9c26aecdf69

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