Publication:
A novel strategy as a potential rapid therapy modality in the treatment of corneal ulcers: Fluconazole/vancomycin dual drug-loaded nanofibrous patches

Simple item page
dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorTINAZ, GÜLGÜN
dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsCESUR S., Ilhan E., Pilavci E., Sulutas R. B., Gurboga M., BİNGÖL ÖZAKPINAR Ö., Kaya E., Heljak M., TINAZ G., OKTAR F. N., et al.
dc.date.accessioned2023-05-02T08:15:03Z
dc.date.available2023-05-02T08:15:03Z
dc.date.issued2023-01-01
dc.description.abstractCorneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual-drug loaded dual-layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug-loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug-loaded layers in one patch. According to drug release results, the FLU and VAN-loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4\"-6diamidynofenyloindol (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.
dc.identifier.citationCESUR S., Ilhan E., Pilavci E., Sulutas R. B., Gurboga M., BİNGÖL ÖZAKPINAR Ö., Kaya E., Heljak M., TINAZ G., OKTAR F. N., et al., "A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug-Loaded Nanofibrous Patches", Macromolecular Materials and Engineering, 2023
dc.identifier.doi10.1002/mame.202200697
dc.identifier.issn1438-7492
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152955132&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/289000
dc.language.isoeng
dc.relation.ispartofMacromolecular Materials and Engineering
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemical Engineering and Technology
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMühendislik
dc.subjectMalzeme Bilimi
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectENGINEERING
dc.subjectMATERIALS SCIENCE
dc.subjectCHEMISTRY
dc.subjectENGINEERING, CHEMICAL
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY, ORGANIC
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectGenel Kimya Mühendisliği
dc.subjectFizik Bilimleri
dc.subjectOrganik Kimya
dc.subjectPolimerler ve Plastikler
dc.subjectMalzeme Kimyası
dc.subjectGeneral Chemical Engineering
dc.subjectPhysical Sciences
dc.subjectOrganic Chemistry
dc.subjectPolymers and Plastics
dc.subjectMaterials Chemistry
dc.subjectcorneal tissue engineering
dc.subjectcorneal ulcers
dc.subjectelectrospinning
dc.subjectfluconazole
dc.subjectvancomycin
dc.titleA novel strategy as a potential rapid therapy modality in the treatment of corneal ulcers: Fluconazole/vancomycin dual drug-loaded nanofibrous patches
dc.typearticle
dspace.entity.typePublication
local.avesis.id44631459-e890-4f13-ace1-f0d096c076d7
local.indexed.atSCOPUS
relation.isAuthorOfPublication155dc947-cf5f-46e3-8ddb-0a1e9751e23f
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication04cb59f2-2e4f-4b7f-b8f9-653ea79728d6
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscovery155dc947-cf5f-46e3-8ddb-0a1e9751e23f

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
7.pdf
Size:
7.43 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs