Publication: Clinical outcomes of adjuvant radiotherapy for nodal negative T1 and T2 breast cancer
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Date
2022-07-01
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Abstract
The objective of this study was to determine the long
-term results of
postoperative radiotherapy (RT) in patients with node
-negative T1
–T2 breast cancer
and the prognostic factors affecting these results. Materials and Methods
: We
retrospectively evaluated 382 node
-negative breast cancer patients (pT1a
–c, T2)
treated with surgery. All patients underwent postoperative RT and 80% of patients
received hormone therapy. Prognostic variables included patient characteristics,
disease characteristics, and intervention factors. The primary endpoint was overall
survival (OS). Survival curves were estimated using the Kaplan
–Meier method.
Differences in observed survival distributions among patient subgroups were
evaluated using a two
-sided long
-rank test. We applied univariate and multivariate
Cox models to evaluate predictive factors. Statistical significance was evaluated at a
level of
P < 0.05. Results
: The median follow
-up was 143 months. The 10
-, 15
-, and 20
-
year OS rates were 92%, 86%, and 80%, respectively. Univariate analysis showed that
age (< 45, 45
–65, > 65 years; P < 0.0001), comorbidity (P = 0.008), menopausal status
(P = 0.03), and tumor stage (T1a
–c, T2; P = 0.006) (table 1) were significant predictors
of OS. Multivariate analysis showed that age (< 45, 45
–65, > 65; P = 0.01) and tumor
stage (T1a
–c, T2; P < 0.0001) were independent predictors of OS. At age 15 years, the
OS rate of patients with T1b, T1c, or T2 stage cancer was 87.5%, 81%, or 77%,
respectively. Conclusions
: Age and tumor stage were independent prognostic factors
for women with node
-negative early breast cancer.
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Keywords
Tıp, Sağlık Bilimleri, Medicine, Health Sciences, Klinik Tıp (MED), Klinik Tıp, Clinical Medicine (MED), CLINICAL MEDICINE, Early-stage breast cancer, prognostic factors, radiotherapy, survival, COMPARING TOTAL MASTECTOMY, 20-YEAR FOLLOW-UP, CONSERVING SURGERY, POSTOPERATIVE RADIOTHERAPY, SECTOR RESECTION, IRRADIATION, WOMEN, LUMPECTOMY, SURVIVAL, TRIAL, Early-stage breast cancer, prognostic factors, radiotherapy, survival
Citation
ALSAN ÇETİN İ., Akay S., Ozkok H., Sengoz M., "Clinical outcomes of adjuvant radiotherapy for nodal negative T1 and T2 breast cancer", International Journal of Radiation Research, cilt.20, sa.3, ss.601-605, 2022