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Clinical outcomes of adjuvant radiotherapy for nodal negative T1 and T2 breast cancer

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dc.contributor.authorALSAN ÇETİN, İLKNUR
dc.contributor.authorsALSAN ÇETİN İ., Akay S., Ozkok H., Sengoz M.
dc.date.accessioned2023-08-07T10:24:07Z
dc.date.available2023-08-07T10:24:07Z
dc.date.issued2022-07-01
dc.description.abstractThe objective of this study was to determine the long -term results of postoperative radiotherapy (RT) in patients with node -negative T1 –T2 breast cancer and the prognostic factors affecting these results. Materials and Methods : We retrospectively evaluated 382 node -negative breast cancer patients (pT1a –c, T2) treated with surgery. All patients underwent postoperative RT and 80% of patients received hormone therapy. Prognostic variables included patient characteristics, disease characteristics, and intervention factors. The primary endpoint was overall survival (OS). Survival curves were estimated using the Kaplan –Meier method. Differences in observed survival distributions among patient subgroups were evaluated using a two -sided long -rank test. We applied univariate and multivariate Cox models to evaluate predictive factors. Statistical significance was evaluated at a level of P < 0.05. Results : The median follow -up was 143 months. The 10 -, 15 -, and 20 - year OS rates were 92%, 86%, and 80%, respectively. Univariate analysis showed that age (< 45, 45 –65, > 65 years; P < 0.0001), comorbidity (P = 0.008), menopausal status (P = 0.03), and tumor stage (T1a –c, T2; P = 0.006) (table 1) were significant predictors of OS. Multivariate analysis showed that age (< 45, 45 –65, > 65; P = 0.01) and tumor stage (T1a –c, T2; P < 0.0001) were independent predictors of OS. At age 15 years, the OS rate of patients with T1b, T1c, or T2 stage cancer was 87.5%, 81%, or 77%, respectively. Conclusions : Age and tumor stage were independent prognostic factors for women with node -negative early breast cancer.
dc.identifier.citationALSAN ÇETİN İ., Akay S., Ozkok H., Sengoz M., "Clinical outcomes of adjuvant radiotherapy for nodal negative T1 and T2 breast cancer", International Journal of Radiation Research, cilt.20, sa.3, ss.601-605, 2022
dc.identifier.doi10.52547/ijrr.20.3.12
dc.identifier.endpage605
dc.identifier.issn2322-3243
dc.identifier.issue3
dc.identifier.startpage601
dc.identifier.urihttp://ijrr.com/article-1-4346-en.pdf
dc.identifier.urihttps://hdl.handle.net/11424/292142
dc.identifier.volume20
dc.language.isoeng
dc.relation.ispartofInternational Journal of Radiation Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectEarly-stage breast cancer
dc.subjectprognostic factors
dc.subjectradiotherapy
dc.subjectsurvival
dc.subjectCOMPARING TOTAL MASTECTOMY
dc.subject20-YEAR FOLLOW-UP
dc.subjectCONSERVING SURGERY
dc.subjectPOSTOPERATIVE RADIOTHERAPY
dc.subjectSECTOR RESECTION
dc.subjectIRRADIATION
dc.subjectWOMEN
dc.subjectLUMPECTOMY
dc.subjectSURVIVAL
dc.subjectTRIAL
dc.subjectEarly-stage breast cancer
dc.subjectprognostic factors
dc.subjectradiotherapy
dc.subjectsurvival
dc.titleClinical outcomes of adjuvant radiotherapy for nodal negative T1 and T2 breast cancer
dc.typearticle
dspace.entity.typePublication
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local.indexed.atWOS
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscoveryfab5ec4d-b078-4832-a240-29c00f3c424c

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