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Levan based fibrous scaffolds electrospun via co-axial and single-needle techniques for tissue engineering applications

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dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsAvsar, Gulben; Agirbasli, Deniz; Agirbasli, Mehmet Ali; Gunduz, Oguzhan; Oner, Ebru Toksoy
dc.date.accessioned2022-03-12T22:27:10Z
dc.date.available2022-03-12T22:27:10Z
dc.date.issued2018
dc.description.abstractThis represents the first systematic study where levan polysaccharide was used to fabricate fibrous matrices by co-axial and single-needle electrospinning techniques. For this, hydrolyzed (hHL) and sulfated hydrolyzed (ShHL) Halomonas levan were chemically synthesized and used together with polycaprolactone (PCL) and polyethyleneoxide (PEO) for the spinning process. In co-axially spun matrices, ultimate tensile strength (UTS) were found to increase with increasing ShHL concentration and elongation at break of PCL + ShHL matrices increased up to ten-fold when compared to PCL matrices. Similarly, in single-needle spun matrices, higher elongation at break values were obtained by blending HL and ShHL with PEO pointing to the effective energy absorbing features. Dense and fine fibers were characterized by FTIR and SEM. Cell viability and fluorescence imaging of L929 fibroblasts and HUVECs as well as heparin mimetic activity of the matrices pointed to their high potential to be used in decreasing neointimal proliferation and thrombogenicity of grafts and prosthesis.
dc.identifier.doi10.1016/j.carbpol.2018.03.075
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pubmed29773387
dc.identifier.urihttps://hdl.handle.net/11424/235168
dc.identifier.wosWOS:000432775700036
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofCARBOHYDRATE POLYMERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHalomonas levan
dc.subjectCo-axial electrospinning
dc.subjectScaffolds
dc.subjectFTIR
dc.subjectAnticoagulation
dc.subjectTissue engineering
dc.subjectHALOMONAS SMYRNENSIS AAD6(T)
dc.subjectBIOMEDICAL APPLICATIONS
dc.subjectMULTILAYER FILMS
dc.subjectSTENT THROMBOSIS
dc.subjectVASCULAR GRAFT
dc.subjectSULFATED LEVAN
dc.subjectHEPARIN
dc.subjectREGENERATION
dc.subjectNANOFIBERS
dc.subjectEXOPOLYSACCHARIDES
dc.titleLevan based fibrous scaffolds electrospun via co-axial and single-needle techniques for tissue engineering applications
dc.typearticle
dspace.entity.typePublication
local.avesis.idd0666007-ea88-4939-aea6-354e8a37e58e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.endPage325
oaire.citation.startPage316
oaire.citation.titleCARBOHYDRATE POLYMERS
oaire.citation.volume193
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery6118e9e4-a58e-429b-bbec-4f73a3089a2b

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