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Encapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material

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dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsGurler, Esra Bihter; Ergul, Necdet Mekki; Ozbek, Burak; Ekren, Nazmi; Oktar, Faik Nuzhet; Haskoylu, Merve Erginer; Oner, Ebru Toksoy; Eroglu, Mehmet Sayip; Ozbeyli, Dilek; Korkut, Veysel; Temiz, Ahmet Furkan; Kocanali, Nil; Gungordu, Rosa Juvan; Kilickan, Duhan Berkan; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:38:39Z
dc.date.available2022-03-12T22:38:39Z
dc.date.issued2019
dc.description.abstractElectrospraying assures many advantages with taking less time and costing less relatively to the other conventional particle production methods. In this research, we investigated the encapsulation of melatonin (MEL) hormone in polycaprolactone (PCL) microparticles by using electrospraying method. Morphology analysis of the produced particles completed with Scanning Electron Microscopy (SEM). SEM images demonstrated that microparticles of 3 wt% PCL solution has the most suitable particle diameter size (2.3 +/- 0.64 mu m) for melatonin encapsulation. According to the characterization of the particles, electrospraying parameters like optimal collecting distance, the flow rate of the solution and voltage of the system detected as 8 cm, 0.5 ml/h, and 10 kV respectively. For determining the chemical bonds of scaffold Fourier-Transform Infrared Spectroscopy (FTIR) were used and FTIR results showed that melatonin successfully loaded into PCL micro-particles. Drug release kinetics of the melatonin loaded particles indicated that melatonin released with a burst at the beginning and release behavior became sustainable over a period of 8 h with the encapsulation efficiency of about 73%. In addition, both in-vitro and in-vivo studies of the graft materials also completed. Primary human osteoblasts (HOB) cells and female Sprague Dawley rats were used in in-vitro and in-vivo studies. Test results demonstrate cell population, and bone volume of the rats grafted with composites has remarkably increased, this caused remodelling in bone structure. Overall, these findings indicate that encapsulation of melatonin in the PCL particles with electrospray method is optimum for new synthetic graft material.
dc.identifier.doi10.1016/j.msec.2019.03.051
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pubmed30948117
dc.identifier.urihttps://hdl.handle.net/11424/235698
dc.identifier.wosWOS:000466059700077
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMelatonin
dc.subjectBiodegradable polymer
dc.subjectElectrospraying
dc.subjectGraft
dc.subjectIRON-OXIDE NANOPARTICLES
dc.subjectBONE-FORMATION
dc.subjectEPSILON-CAPROLACTONE
dc.subjectSINUS AUGMENTATION
dc.subjectIN-VITRO
dc.subjectMICROSPHERES
dc.subjectELECTROSPUN
dc.subjectDRUG
dc.subjectDIFFERENTIATION
dc.subjectDELIVERY
dc.titleEncapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material
dc.typearticle
dspace.entity.typePublication
local.avesis.idaca312fb-bfd7-435b-9609-e1079fe5b3dd
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
local.journal.quartileQ1
oaire.citation.endPage808
oaire.citation.startPage798
oaire.citation.titleMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
oaire.citation.volume100
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery4681bb67-e40b-4cf0-8154-5472237f2325

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