Publication:
Fluconazole and cinnamaldehyde loaded-multilayer elektrospun nanofibers for the treatment of fungal keratitis

Simple item page
dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsİlhan E., Cesur S., Oktar F. N., Gündüz O.
dc.date.accessioned2023-03-07T11:15:45Z
dc.date.available2023-03-07T11:15:45Z
dc.date.issued2022-06-24
dc.description.abstractInflammation of the cornea due to physical, chemical and infectious causes is known as keratitis[1]. Fungi are one of the most challenging species to diagnose and treat among the organisms that cause keratitis. Moreover, fungal keratitis has been proven to be more virulent and destructive than keratitis caused by bacterias[2]. In this study, two-layer polyvinyl alcohol and gelatin (PVA/GEL) nanofibers loaded with different biological agents, which accelerate wound closure by suppressing the disadvantages of traditional methods in the treatment of fungal keratitis, were produced by the electrospinning method. Cinnamaldehyde (CA), an FDA-approved volatile molecule found in cinnamon essential oil, and fluconazole (FLU), an antifungal drug, were incorporated into PVA/GEL nanofibers to inhibit the growth and biofilm formation of Candida albicans, one of the pathogens that cause fungal keratitis. The morphology, and chemical structures of the produced pure (PVA/GEL), FLU loaded (PVA/GEL/FLU), CA loaded (PVA/GEL/CA), and combined FLU and CA loaded (PVA/GEL/COM) nanofibers were analysed by scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FT-IR), respectively. The mechanical analysis and drug release kinetics of the nanofibers were investigated. PVA/GEL/FLU, PVA/GEL/CA and PVA/GEL/FLU/COM nanofibers were evaluated for their antifungal and antibiofilm activity against Candida albicans. Results showed that PVA/GEL/FLU and PVA/GEL/COM nanofibers have significant antifungal activity and inhibited biofilm formation by 37% and 49%, respectively. The originality of this study lays in the design of the multilayer electrospun nanofibers, which are loaded with both biofilm inhibitor agent and an antifungal drug. This kind of construct can be utilised in the treatment of fungal keratitis and to produce patches that accelerate wound healing and allow controlled release of the bio-active agents.
dc.identifier.citationİlhan E., Cesur S., Oktar F. N., Gündüz O., \"Fluconazole and Cinnamaldehyde Loaded-Multilayer Elektrospun Nanofibers for the Treatment of Fungal Keratitis\", Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2022 – Summer Edition, Bucuresti, Romanya, 22 - 24 Haziran 2022, ss.1
dc.identifier.startpage117
dc.identifier.urihttps://nanobiomat.eu/previous-editions/
dc.identifier.urihttps://hdl.handle.net/11424/287260
dc.language.isoeng
dc.relation.ispartofApplications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2022 – Summer Edition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSağlık Bilimleri
dc.subjectMühendislik ve Teknoloji
dc.subjectHealth Sciences
dc.subjectEngineering and Technology
dc.subjectKlinik Tıp (MED)
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectClinical Medicine (MED)
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectFungal Keratitis
dc.subjectNanofiber
dc.subjectFluconazole
dc.subjectCinnamaldehyde
dc.subjectCornea Tissue Engineering
dc.titleFluconazole and cinnamaldehyde loaded-multilayer elektrospun nanofibers for the treatment of fungal keratitis
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.ided07b408-887b-47b8-9e48-d7916be5eeb2
relation.isAuthorOfPublication155dc947-cf5f-46e3-8ddb-0a1e9751e23f
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscovery155dc947-cf5f-46e3-8ddb-0a1e9751e23f

Files

Collections

Research Outputs