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Functional and clinical evaluation of renal injury in patients treated with adjuvant chemoradiotherapy for gastric cancer: Low dose and comorbidity considerations

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsIbrahimov, Roman; Atasoy, Beste M.; Dede, Fuat; Arikan, Hakki; Ozen, Zeynep; Ozgen, Zerrin; Dane, Faysal; Abacioglu, Ufuk
dc.date.accessioned2022-03-14T08:14:17Z
dc.date.available2022-03-14T08:14:17Z
dc.date.issued2016-01
dc.description.abstractAim: To analyze the dosimetric factors affecting long-term renal function in patients with gastric cancer following postoperative radiotherapy with concomitant chemotherapy to the upper abdomen. Methods: Between January 2005 and July 2010, 13 patients treated with three-dimensional conformal radiotherapy and concurrent fluorouracil-based chemotherapy (CRT) were included in this analysis. After a median follow-up of 55 months, creatinine, glomerular filtration rate (GFR), total kidney and left kidney volumes, before and after CRT and mercaptoacetyltriglycine (MAG3) scintigraphy, were used to evaluate the renal function and were correlated with the dosimetrics data. Results: Significant correlations were found in the loss of left kidney volume and V35 (20.6%) (p = 0.035) and V40 (15.7%) (p = 0.031) and in the loss of relative functional contribution of the main kidney and V35 Gy (p = 0.027) and V40 Gy (p = 0.019). In patients with a slightly low basal GFR (n = 6), the relative functional contribution of the left kidney significantly decreased, regardless of the dosage. Conclusion: Functional renal impairment without any clinical signs or symptoms can be observed in low doses after radiotherapy. Careful treatment planning and a detailed evaluation of the functional renal capacity before treatment may help to reduce late renal toxicity. Copyright (C) 2015, The Egyptian Society of Radiation Sciences and Applications. Production and hosting by Elsevier B.V.
dc.identifier.doi10.1016/j.jrras.2015.09.004
dc.identifier.issn1687-8507
dc.identifier.urihttps://hdl.handle.net/11424/241224
dc.identifier.wosWOS:000389351000010
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComorbidity
dc.subjectDose volume effect
dc.subjectLate effect
dc.subjectRadiotherapy
dc.subjectRenal toxicity
dc.subjectRADIATION NEPHROPATHY
dc.subjectNORMAL TISSUE
dc.subjectIRRADIATION
dc.subjectTOXICITY
dc.subjectCISPLATIN
dc.subjectTOLERANCE
dc.titleFunctional and clinical evaluation of renal injury in patients treated with adjuvant chemoradiotherapy for gastric cancer: Low dose and comorbidity considerations
dc.typearticle
dspace.entity.typePublication
local.avesis.id4a2936cb-0d96-4cb9-a8d1-e673c2b8f0b3
local.import.packageSS16
local.indexed.atWOS
local.journal.numberofpages5
oaire.citation.endPage67
oaire.citation.issue1
oaire.citation.startPage63
oaire.citation.titleJOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
oaire.citation.volume9
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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