Publication:
Potential Adjuvant Effects of Nigella sativa Seeds to Improve Specific Immunotherapy in Allergic Rhinitis Patients

Simple item page
dc.contributor.authorGÜRBÜZ, BURÇAK
dc.contributor.authorsIsik, Huelya; Cevikbas, Adile; Gurer, Umran Soyogul; Kiran, Bayram; Uresin, Yagiz; Rayaman, Pervin; Rayaman, Erkan; Gurbuz, Burcak; Buyukozturk, Suna
dc.date.accessioned2022-03-14T09:28:31Z
dc.date.available2022-03-14T09:28:31Z
dc.date.issued2010
dc.description.abstractObjective: To investigate the effects of Nigella sativa seed supplementation on symptom levels, polymorphonuclear leukocyte (PMN) functions, lymphocyte subsets and hematological parameters of allergic rhinitis. Subjects and Methods: Twenty-four patients randomly selected from an experimental group of 31 (mean age 34 years) sensitive to house dust mites with allergic rhinitis and a control group of 8 healthy volunteers (mean age 23 years) were treated with allergen-specific immunotherapy in conventional doses for 30 days. After a month of immunotherapy, 12 of the 24 patients and the 8 healthy volunteers were given N. sativa seed supplementation (2 g/day orally) for 30 days. The remaining 12 patients continued only on immunotherapy during the same period. The other 7 patients were given 0.1 ml saline solution subcutaneously once a week as a placebo. The symptom scores, PMN functions, lymphocyte subsets and other hematological parameters were evaluated before and after all treatment periods. Results: There was a statistically significant increase in the phagocytic and intracellular killing tivities of PMNs of patients receiving specific immunotherapy, especially after the addition of N. sativa seed. The CD8 counts of patients receiving specific immunotherapy plus N. sativa seed supplementation significantly increased compared to patients receiving only specific immunotherapy. PMN functions of healthy volunteers significantly increased after N. sativa seed supplementation compared to baseline. Conclusion: N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy. Copyright (C) 2010 S. Karger AG, Basel
dc.identifier.doi10.1159/000285289
dc.identifier.eissn1423-0151
dc.identifier.issn1011-7571
dc.identifier.pubmed20357504
dc.identifier.urihttps://hdl.handle.net/11424/243169
dc.identifier.wosWOS:000276245800008
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofMEDICAL PRINCIPLES AND PRACTICE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNigella sativa
dc.subjectPhagocytosis
dc.subjectIntracellular killing activity
dc.subjectAllergic rhinitis
dc.subjectActive immunotherapy
dc.subjectMOUSE MODEL
dc.subjectBLACK SEED
dc.subjectTHYMOQUINONE
dc.subjectCELLS
dc.subjectOIL
dc.titlePotential Adjuvant Effects of Nigella sativa Seeds to Improve Specific Immunotherapy in Allergic Rhinitis Patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id83a8ee1a-0804-421a-9fe4-177da73b4b4e
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage211
oaire.citation.issue3
oaire.citation.startPage206
oaire.citation.titleMEDICAL PRINCIPLES AND PRACTICE
oaire.citation.volume19
relation.isAuthorOfPublicationa75e1636-dea5-448e-bcd2-0f95b335af6a
relation.isAuthorOfPublication.latestForDiscoverya75e1636-dea5-448e-bcd2-0f95b335af6a

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Işık et al. - 2010 - Potential Adjuvant Effects of Nigella sativai.pdf
Size:
185.11 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs