Publication:
FDG PET/CT features of polysaccharide-based hemostatic agent chronic inflammatory changes can mimic metastatic lesions

Simple item page
dc.contributor.authorKOCAKAYA, DERYA
dc.contributor.authorASLAN, SEZER
dc.contributor.authorBOZKURTLAR, EMİNE
dc.contributor.authorsBozkurtlar E., Oksuzoglu K., Bostanci K., Aslan S., Kissa T. N., Kocakaya D., Ones T.
dc.date.accessioned2023-04-28T06:47:50Z
dc.date.available2023-04-28T06:47:50Z
dc.date.issued2022-07-01
dc.description.abstractPurpose To prevent hemorrhagic complications, hemostatic agents (HAs) have been widely used in recent years. The use of HAs can lead to false-positive results on postoperative imaging. There exists only 1 study in the literature evaluating these applications during surgical procedures. Therefore, we aimed to evaluate the postoperative imaging features of polysaccharide-based HAs in thoracic surgery patients who have had F-18-FDG PET/CT scans. Patients and Methods Two hundred nine consecutive patients who underwent thoracic surgery were enrolled in this study. A topical polysaccharide-based HA was applied to the surgical bed for all of the patients. The patients diagnosed with cancer were followed up with subsequent thoracic CT scans, and 42 of these patients were also imaged with F-18-FDG PET/CT, which then comprised the main study group. Due to suspicion of metastasis, 19/42 patients were reoperated or rebiopsied. The latest histopathological findings were accepted as criterion standard, and previous FDG PET/CT images were retrospectively reevaluated. Results Polysaccharide-based HAs that appear as amorphous basophilic material were identified in histopathological samples of 11/19 patients. Lymphocytes, plasma cells, and histiocytes, which formed foreign body reaction and/or foreign body granuloma, indicating the presence of chronic inflammation, were seen in all of the samples. F-18-FDG PET/CT showed increased FDG uptake in all of these lesions. Conclusions Despite the inconsistency of the literature, polysaccharide-based HAs can be demonstrated in human surgical specimens as amorphous basophilic materials even after a long time from the initial surgical procedure. These agents almost always cause chronic inflammatory changes. In addition, these agents may mimic \"false-positive\" findings on postoperative FDG PET/CT scans.
dc.identifier.citationBozkurtlar E., Oksuzoglu K., Bostanci K., Aslan S., Kissa T. N., Kocakaya D., Ones T., "FDG PET/CT Features of Polysaccharide-Based Hemostatic Agent Chronic Inflammatory Changes Can Mimic Metastatic Lesions", CLINICAL NUCLEAR MEDICINE, cilt.47, sa.7, 2022
dc.identifier.doi10.1097/rlu.0000000000004216
dc.identifier.issn0363-9762
dc.identifier.issue7
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35452003/
dc.identifier.urihttps://hdl.handle.net/11424/288977
dc.identifier.volume47
dc.language.isoeng
dc.relation.ispartofCLINICAL NUCLEAR MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNükleer Tıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectNuclear medicine
dc.subjectHealth Sciences
dc.subjectRADYOLOJİ, NÜKLEER TIP ve MEDİKAL GÖRÜNTÜLEME
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectRadyoloji ve Ultrason Teknolojisi
dc.subjectRadyoloji, Nükleer Tıp ve Görüntüleme
dc.subjectRadiological and Ultrasound Technology
dc.subjectRadiology, Nuclear Medicine and Imaging
dc.subjectFDG PET
dc.subjectCT
dc.subjecthemostatic agent
dc.subjectchronic inflammation
dc.subjectforeign body reaction
dc.subjectforeign body granuloma
dc.subjectfalse-positive assessment
dc.subjectPOSITRON-EMISSION-TOMOGRAPHY
dc.subjectHEMOSPHERES MPH
dc.subjectCELLULOSE
dc.subjectMANAGEMENT
dc.subjectEFFICACY
dc.subjectSURGERY
dc.subjectPOWDER
dc.subjectBRAIN
dc.titleFDG PET/CT features of polysaccharide-based hemostatic agent chronic inflammatory changes can mimic metastatic lesions
dc.typearticle
dspace.entity.typePublication
local.avesis.id6edfdaa2-ed34-431a-a7a6-c57cd29c7393
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication2771cdd6-7c3b-45a8-89fe-a429a2950516
relation.isAuthorOfPublication6e5f6097-90a8-4a1f-a09b-3fd6f002d71d
relation.isAuthorOfPublication2343a71e-12cf-42ea-89ed-b222d121f733
relation.isAuthorOfPublication.latestForDiscovery2771cdd6-7c3b-45a8-89fe-a429a2950516

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
3.pdf
Size:
807.84 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs