Publication:
EFFECT OF VERAPAMIL AND ILOPROST (ZK-36374) ON ENDOTHELIN RELEASE AFTER MESENTERIC ISCHEMIA-REPERFUSION INJURY

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsYEGEN, C; AKTAN, AO; BUYUKGEBIZ, O; HAKLAR, G; YALCIN, AS; YALIN, R; ERCAN, S
dc.date.accessioned2022-03-12T16:55:53Z
dc.date.available2022-03-12T16:55:53Z
dc.date.issued1994
dc.description.abstractIn this experimental study we studied the effect of verapamil and iloprost on endothelin release in ischemia/reperfusion (IR) injury of the rat intestine. Endothelin levels in the portal blood and malondialdehyde (MDA), PGE2, and LTC4 levels in the intestinal tissue were determined. The MDA levels increased in the control group and this increase was reversed with iloprost, verapamil and both. The change in the LTC4 levels was insignificant between the groups. Iloprost reduced PGE2 and endothelin release, but verapamil was not as effective and no synergistic effect was encountered. The increased PGE2/LTC4 ratio was also reversed in the experimental groups, verapamil being less effective. Endothelin release seems to be related to both PGE2 levels and the PGE2/LTC4 ratio after mesenteric IR injury.
dc.identifier.doi10.1159/000129320
dc.identifier.eissn1421-9921
dc.identifier.issn0014-312X
dc.identifier.pubmed7516292
dc.identifier.urihttps://hdl.handle.net/11424/226587
dc.identifier.wosWOS:A1994NE00300001
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofEUROPEAN SURGICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectISCHEMIA REPERFUSION INJURY
dc.subjectENDOTHELIN
dc.subjectVERAPAMIL
dc.subjectILOPROST
dc.subjectMECHANISMS
dc.titleEFFECT OF VERAPAMIL AND ILOPROST (ZK-36374) ON ENDOTHELIN RELEASE AFTER MESENTERIC ISCHEMIA-REPERFUSION INJURY
dc.typearticle
dspace.entity.typePublication
local.avesis.id4ab95743-f17d-4fd2-b44e-d80146a0599f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage75
oaire.citation.issue2
oaire.citation.startPage69
oaire.citation.titleEUROPEAN SURGICAL RESEARCH
oaire.citation.volume26
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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