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Antioxidant and anti-inflammatory activity of fruit, leaf and branch extracts of Paliurus spina-christi P. Mill.

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsSen, Ali
dc.date.accessioned2022-03-14T08:32:22Z
dc.date.available2022-03-14T08:32:22Z
dc.date.issued2018-04-06
dc.description.abstractIn this study, it is aimed to investigate antioxidant and anti-inflammatory activities of ethanol extracts and their n-hexane, chloroform, ethylacetate, and aqueous ethanol fractions of the fruits, leaves, and branches of Paliurus spinachristi P. Mill. (Rhamnaceae). The antioxidant activity of the extracts was tested by DPPH and ABTS methods and the results were expressed as IC50 values. The total phenolic content was determined by Folin-Ciocalteu method and the results were expressed as mg of gallic acid equivalent per g dry extract. Anti-inflammatory activity of extracts were evaluated against 5-lipoxygenase enzyme. In particular, all extracts obtained from branches of P. spina-christi, except hexane extract, showed strong antioxidant activity against DPPH and ABTS radicals. Ethyl acetate and ethanol extracts of branches of P. spina-christi showed the highest antioxidant activity in DPPH and ABTS assays with IC50 values of 15.54 and 22.06 mu g/ml, respectively. Also, the highest total phenol content was found in the ethylacetate extract of branches of P. spina-christi (286.6 mg/g). Ethyl acetate and ethanol extracts of leaves of P. spina-christi with IC50 values of 66.28 and 76.75 j mu g/ml were found to have the best anti-inflammatory activity in the lipoxygenase (LOX) inhibition assay used to evaluate anti-inflammatory activities of extracts. These results demonstrate that ethanol and ethyl acetate extracts from branches and leaves of Paliurus spina-christi have significant antioxidant and anti-inflammatory activity. Also, these results confirm the folk use of the plant as an antiinflammatory medicine.
dc.identifier.doi10.12991/mpj.2018.71
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/241942
dc.identifier.wosWOS:000438786000023
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPaliurus spina-christi P. Mill.
dc.subjectRhamnaceae
dc.subjectAntioxidant activity
dc.subjectAnti-inflammatory activity
dc.subjectFOLK MEDICINAL-PLANTS
dc.subjectTURKEY
dc.subjectFLAVONOIDS
dc.subjectISTANBUL
dc.subjectTHORN
dc.titleAntioxidant and anti-inflammatory activity of fruit, leaf and branch extracts of Paliurus spina-christi P. Mill.
dc.typearticle
dspace.entity.typePublication
local.avesis.id449cd263-e5c3-4b09-ab07-816ae1175b12
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage333
oaire.citation.issue2
oaire.citation.startPage328
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume22
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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