Publication:
A novel approach to treat the Thiel-Behnke corneal dystrophy using 3D printed honeycomb-shaped polymethylmethacrylate (PMMA)/Vancomycin (VAN) scaffolds

Simple item page
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsUlag S., Sahin A., Guncu M.M., Aksu B., Ekren N., Sengor M., Kalaskar D.M., Gunduz O.
dc.date.accessioned2022-03-15T02:16:17Z
dc.date.available2022-03-15T02:16:17Z
dc.date.issued2021
dc.description.abstractThiel-Behnke corneal dystrophy, or honeycomb corneal dystrophy, is an autosomal dominant corneal disorder. Tissue engineering can be a novel approach to regenerate this dystrophy. In this study, the honeycomb geometry of the dystrophy mimicked with a 3D printing technology, and 40% PMMA, 40% PMMA/(0.1, 0.5, 2, and 10)% VAN scaffolds were fabricated with honeycomb geometry. As a result of the biocompatibility test with mesenchymal stem cells (MSCs), it can be said that cells on the scaffolds showed high viability and proliferation for all incubation periods. According to the antibacterial activity results, the 40% PMMA/10% VAN showed antibacterial activity against S. aureous. Mechanical results reported that with the addition of VAN into the 40% PMMA, the tensile strength value increased up to 2% VAN amount. The swelling behaviours of the scaffolds were examined in vitro, and found that the swelling rate increased with a high VAN amount. The release of VAN from the scaffolds showed sustained release behaviour, and it took 13 days to be released entirely from the scaffolds. © 2021 Elsevier B.V.
dc.identifier.doi10.1016/j.bprint.2021.e00173
dc.identifier.issn24058866
dc.identifier.urihttps://hdl.handle.net/11424/248207
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBioprinting
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3D printing
dc.subjectCorneal dystrophy
dc.subjectHoneycomb
dc.subjectPolymethylmethacrylate
dc.subjectThiel-behnke
dc.subjectVancomycin
dc.titleA novel approach to treat the Thiel-Behnke corneal dystrophy using 3D printed honeycomb-shaped polymethylmethacrylate (PMMA)/Vancomycin (VAN) scaffolds
dc.typearticle
dspace.entity.typePublication
local.avesis.id3a280003-707a-465b-852a-3fe4980d7c85
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
local.journal.articlenumbere00173
oaire.citation.titleBioprinting
oaire.citation.volume24
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

Files

Collections

Research Outputs