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Ovarian stem cells: From basic to clinical applications

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dc.contributor.authorÖZSAVCI, DERYA
dc.contributor.authorsOzakpinar, Ozlem Bingol; Maurer, Anne-Marie; Ozsavci, Derya
dc.date.accessioned2022-03-10T11:40:13Z
dc.date.available2022-03-10T11:40:13Z
dc.date.issued2015
dc.description.abstractThe field of reproductive biology has undergone significant developments in the last decade. The notion that there is a fixed reserve pool of oocytes before birth was established by Zuckerman in 1951. However, in 2004, an article published in nature challenged this central dogma of mammalian reproductive biology. Tilly's group reported the existence of ovarian germline stem cells (GSCs) in postnatal ovaries of mice and suggested that the bone marrow could be an extragonadal source of ovarian GSCs. These findings were strongly criticized
dc.description.abstracthowever, several independent groups have since successfully isolated and characterized ovarian GSCs in postnatal mice. The ovarian GSCs are located in the ovarian surface epithelium and express markers of undifferentiated GSCs. When transplanted into mouse ovaries, mouse ovarian GSCs could differentiate and produce embryos and offspring. Similarly, in a recent study, ovarian GSCs were found to be present in the ovaries of women of reproductive age. Conversely, there is increasing evidence that stem cells responsible for maintaining a healthy state in normal tissue may be a source of some cancers, including ovarian cancer. Cancer stem cells (CSCs) have been found in many tissues, including ovaries. Some researchers have suggested that ovarian cancer may be a result of the transformation and dysfunction of ovarian GSCs with self-renewal properties. Drug resistant and metastasis-generating CSCs are responsible for many important problems affecting ovarian cancer patients. Therefore, the identification of CSCs will provide opportunities for the development of new therapeutic strategies for treatments for infertility and ovarian cancer. In this article, we summarize the current understanding of ovarian GSCs in adult mammals, and we also discuss whether there is a relationship between GSCs and CSCs.
dc.identifier.doi10.4252/wjsc.v7.i4.757
dc.identifier.issn1948-0210
dc.identifier.pubmed26029346
dc.identifier.urihttps://hdl.handle.net/11424/219976
dc.identifier.wosWOS:000211112700008
dc.language.isoeng
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.relation.ispartofWORLD JOURNAL OF STEM CELLS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer
dc.subjectCancer stem cell
dc.subjectGermline stem cell
dc.subjectOvary
dc.subjectReproductivity
dc.titleOvarian stem cells: From basic to clinical applications
dc.typereview
dspace.entity.typePublication
local.avesis.id689a0d49-5a1f-4ecd-89d5-33618b6472bf
local.import.packageSS4
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.numberofpages12
oaire.citation.endPage768
oaire.citation.issue4
oaire.citation.startPage757
oaire.citation.titleWORLD JOURNAL OF STEM CELLS
oaire.citation.volume7
relation.isAuthorOfPublication68ec1222-da29-4568-a8e5-56ebd6b48020
relation.isAuthorOfPublication.latestForDiscovery68ec1222-da29-4568-a8e5-56ebd6b48020

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