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Identification of differentially expressed proteins in atherosclerotic aorta and effect of vitamin E

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsKaga, Elif; Karademir, Betul; Baykal, Ahmet Tarik; Ozer, Nesrin Kartal
dc.date.accessioned2022-03-12T18:08:52Z
dc.date.available2022-03-12T18:08:52Z
dc.date.issued2013
dc.description.abstractAtherosclerosis is a chronic inflammatory disorder that occurs as a result of mononuclear lymphocyte infiltration to the arterial wall, smooth muscle cell proliferation and damage in the arterial wall caused by extracellular matrix accumulation. Besides several genetic and environmental factors, increased serum cholesterol and oxidized low density lipoproteins are considered to be major inducing factors of atherosclerosis. Several protective agents have been used to prevent the progression of atherosclerosis and recently vitamin E has been focused because of its significant role in signaling mechanisms. Since many different cell types are involved in the development of hypercholesterolemia induced atherosclerosis, it is important to investigate wide range of proteins to highlight the pathologic and diagnostic mechanisms. In this study, by using proteomic technique, we identified differentially expressed proteins following cholesterol and also vitamin E treatments. The expressions of apolipoprotein AI and apolipoprotein E involved in lipid metabolism, peroxiredoxin 1, peroxiredoxin 2 and thioredoxin involved in antioxidant system, 14-3-3 protein zeta delta and 14-3-3 protein beta alpha in cell signaling, biglycan, vimentin, tropomyosin and smooth muscle a-actin as structural and contractile proteins have been discussed. Biological significance We observed several protein alterations in aorta of cholesterol fed and vitamin E treated rabbits. These differentially expressed proteins associated with key mechanisms involved in atherosclerosis and signaling mechanisms related with vitamin E. These findings for different proteins might be helpful for deciphering the pathogenesis in atherosclerosis. In addition it provides a new perspective to understand mechanisms of beneficial effect of vitamin E on the signaling pathways in atherogenesis. (C) 2013 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.jprot.2013.06.015
dc.identifier.eissn1876-7737
dc.identifier.issn1874-3919
dc.identifier.pubmed23796494
dc.identifier.urihttps://hdl.handle.net/11424/231208
dc.identifier.wosWOS:000328518000019
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofJOURNAL OF PROTEOMICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtherosclerosis
dc.subjectHypercholesterolemia
dc.subjectVitamin E
dc.subjectProteomic
dc.subjectLOW-DENSITY LIPOPROTEINS
dc.subjectCORONARY-HEART-DISEASE
dc.subjectALPHA-TOCOPHEROL
dc.subjectKINASE-C
dc.subjectAPOLIPOPROTEIN-E
dc.subjectPROTEOMIC ANALYSIS
dc.subjectOXIDATIVE STRESS
dc.subjectANTIOXIDANT
dc.subjectQUANTIFICATION
dc.subjectINFLAMMATION
dc.titleIdentification of differentially expressed proteins in atherosclerotic aorta and effect of vitamin E
dc.typearticle
dspace.entity.typePublication
local.avesis.idba0b04a9-38c4-436a-8da2-90f71b5d37c3
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages14
oaire.citation.endPage273
oaire.citation.startPage260
oaire.citation.titleJOURNAL OF PROTEOMICS
oaire.citation.volume92
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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