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Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population

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dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsTaymaz, Hilal; Erarslan, Serpil; Oner, Ebru Toksoy; Alkan, Tijen; Agirbasli, Mehmet; Kirdar, Betul
dc.date.accessioned2022-03-12T17:33:16Z
dc.date.available2022-03-12T17:33:16Z
dc.date.issued2007
dc.description.abstractCoronary artery disease (CAD) is reported to be associated with some genetic risk factors. Since identification of genetic risk factors for CAD in different ethnic groups is important for the development of new intervention and prevention programs, we investigated the association between the R353Q and -323ins10 polymorphisms in Factor VII gene, C677T mutation in MTHFR, Factor V Leiden and PT G20210A mutations and CAD in Turkish population. The promoter region of the PAI-1 gene was also screened by SSCA (single-stranded conformation analysis) using specifically designed primers. 137 CAD patients with early onset documented by coronary angiography and 41 individuals who had no significant coronary stenosis by angiography as control group were screened for the identification of the polymorphisms. In conclusion, Factor V Leiden was found to be an independent genetic risk factor for CAD in Turkish population. Combined risk assessment indicated that the coexistence of two other inherited thrombophilia markers, namely MTHFR C677T and PT G20210A with Factor V Leiden may increase the risk of the development of the disease in this population. The results of the present study show that there is no statistically significant association between the two polymorphisms in Factor VII gene, MTHFR C677T polymorphism, PT G20210A polymorphism, 4G/5G polymorphism of PAI-1 and CAD in Turkish population. (c) 2006 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.thromres.2005.12.018
dc.identifier.issn0049-3848
dc.identifier.pubmed16472842
dc.identifier.urihttps://hdl.handle.net/11424/228809
dc.identifier.wosWOS:000242682400007
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofTHROMBOSIS RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpolymorphisms
dc.subjectcoagulation factors
dc.subjectthrombosis
dc.subjectcoronary artery disease
dc.subjectPLASMINOGEN-ACTIVATOR INHIBITOR-1
dc.subjectFACTOR-V-LEIDEN
dc.subjectFACTOR-VII GENE
dc.subjectMETHYLENETETRAHYDROFOLATE REDUCTASE MTHFR
dc.subjectFAMILIAL MYOCARDIAL-INFARCTION
dc.subjectVENOUS THROMBOSIS
dc.subjectPROTHROMBIN GENE
dc.subjectHEART-DISEASE
dc.subjectRISK FACTOR
dc.subjectPAI-1 GENE
dc.titleSequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population
dc.typearticle
dspace.entity.typePublication
local.avesis.id5526b5d3-d3cf-485d-8d49-53a8d5c61d66
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage62
oaire.citation.issue1
oaire.citation.startPage55
oaire.citation.titleTHROMBOSIS RESEARCH
oaire.citation.volume119
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery6118e9e4-a58e-429b-bbec-4f73a3089a2b

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