Publication: The effects of apocynin on monosodium glutamate induced liver damage of rats
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Date
2023-07-01
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Abstract
Monosodium glutamate (MSG) is found in refined foods. Apocynin (APO) is a selective NADPH
oxidase (NOX) inhibitor. The aim of this experimental study was to investigate possible effects of
MSG and the curative effects of APO in rats. Twenty-eight male Sprague-Dawley rats were
randomly divided into four groups (Normal control, APO, MSG and MSG + APO, n:7 for each
group). The MSG and MSG + APO groups received 120 mg/kg MSG solution orally for 28
consecutive days. The APO and MSG + APO groups received 25 mg/kg APO solution orally for 5
days until the end of the experiment. At the end of the experiment, all rats were sacrificed and
liver tissue and blood samples were taken for histological, ultrastructural, and biochemical analyses. In the MSG group, vacuolization and loss in glycogen content in the hepatocytes, leukocyte
infiltration and fibrosis in the liver parenchyme and portal triads, were observed. Terminal
deoxynucleotidyl transferase dUTP (TUNEL)-positivity and NADPH oxidase (NOX)-2-positivity
were higher in the MSG group compared with the other experimental groups. The concentrations
of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total
bilirubin, malondialdehyde (MDA), and myeloperoxidase (MPO) were higher, whereas albumin,
glutathione (GSH), and superoxide (SOD) levels were lower in the MSG group. All these data has
been reversed in MSG + APO group. The histological and biochemical criteria indicated the
prominent ameliorating effect of APO on MSG -induced liver injury.
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Tıp, Sağlık Bilimleri, Medicine, Health Sciences, Klinik Tıp (MED), Klinik Tıp, Clinical Medicine (MED), CLINICAL MEDICINE
Citation
Sahin B., Acikel Elmas M., Bingol Ozakpinar Ö., Arbak S., "The Effects of Apocynin on Monosodium Glutamate Induced Liver Damage of Rats", HELIYON, cilt.9, sa.7, ss.17327, 2023