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The effects of apocynin on monosodium glutamate induced liver damage of rats

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsSahin B., Acikel Elmas M., Bingol Ozakpinar Ö., Arbak S.
dc.date.accessioned2023-07-05T12:27:34Z
dc.date.available2023-07-05T12:27:34Z
dc.date.issued2023-07-01
dc.description.abstractMonosodium glutamate (MSG) is found in refined foods. Apocynin (APO) is a selective NADPH oxidase (NOX) inhibitor. The aim of this experimental study was to investigate possible effects of MSG and the curative effects of APO in rats. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups (Normal control, APO, MSG and MSG + APO, n:7 for each group). The MSG and MSG + APO groups received 120 mg/kg MSG solution orally for 28 consecutive days. The APO and MSG + APO groups received 25 mg/kg APO solution orally for 5 days until the end of the experiment. At the end of the experiment, all rats were sacrificed and liver tissue and blood samples were taken for histological, ultrastructural, and biochemical analyses. In the MSG group, vacuolization and loss in glycogen content in the hepatocytes, leukocyte infiltration and fibrosis in the liver parenchyme and portal triads, were observed. Terminal deoxynucleotidyl transferase dUTP (TUNEL)-positivity and NADPH oxidase (NOX)-2-positivity were higher in the MSG group compared with the other experimental groups. The concentrations of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin, malondialdehyde (MDA), and myeloperoxidase (MPO) were higher, whereas albumin, glutathione (GSH), and superoxide (SOD) levels were lower in the MSG group. All these data has been reversed in MSG + APO group. The histological and biochemical criteria indicated the prominent ameliorating effect of APO on MSG -induced liver injury.
dc.identifier.citationSahin B., Acikel Elmas M., Bingol Ozakpinar Ö., Arbak S., "The Effects of Apocynin on Monosodium Glutamate Induced Liver Damage of Rats", HELIYON, cilt.9, sa.7, ss.17327, 2023
dc.identifier.doi10.1016/j.heliyon.2023.e17327
dc.identifier.endpage17327
dc.identifier.issn2405-8440
dc.identifier.issue7
dc.identifier.startpage17327
dc.identifier.urihttps://hdl.handle.net/11424/290841
dc.identifier.volume9
dc.language.isoeng
dc.relation.ispartofHELIYON
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.titleThe effects of apocynin on monosodium glutamate induced liver damage of rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idc3f47161-1e51-4c96-9fe2-740be73f9389
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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