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  • Publication
    Consumer reactions to high-tech wearable textiles: perceived product importance, consumption benefits and price perceptions
    (2022) TURHAN, GÜLDEN; Kaplan, Burçin
    High-tech wearable electronic textiles are emerging technologies that soon seem to become a part of consumers’ lives. In this study, the effects of product type on consumer reactions in accordance with their different consumption benefits such as hedonic, symbolic, and functional were investigated. Price perceptions, consumption benefits in the context of product type, and perceived product importance were expected as determinants of consumer reactions to purchasing high-tech wearable textiles. Data were collected via a structured survey from 327 individuals in Istanbul. The respondents were informed about the product specifications with pictures of Tweet T-shirt, Design Sneakers, and Thermal Cossack. The results, after the factor analysis, ANOVA, correlation tests, and structural equation modeling showed that hedonic, symbolic, and utilitarian benefits affected emotional reaction, but did not affect cognitive reaction and purchasing intention. The hedonic benefit, compared to other benefits, affected emotional reaction more strongly. A significant effect of price awareness was seen on only cognitive reaction. The perceived importance of the product had a strong, positive, and dominant effect on all consumer reactions. With such an effect, it was observed that the possible effects of price and benefit perceptions were eliminated.
  • Publication
    Determining T and B Cell development by TREC/KREC analysis in primary immunodeficiency patients and healthy controls
    (WILEY, 0) Senturk, Gizem; Ng, Yuk Yin; Eltan, Sevgi Bilgic; Baser, Dilek; Ogulur, Ismail; Altindirek, Didem; Firtina, Sinem; Yilmaz, Hulya; Kocamis, Burcu; Kiykim, Ayca; Camcioglu, Yildiz; Ar, Muhlis Cem; Sudutan, Tugce; Beken, Serdar; Temel, Sehime G.; Alanay, Yasemin; Karakoc-Aydiner, Elif; Baris, Safa; Ozen, Ahmet; Ozbek, Ugur; Sayitoglu, Muge; Ng, Ozden Hatirnaz
    T cell receptor excision circles (TRECs) and kappa-deleting excision circles (KRECs) are DNA fragments potentially indicative of T and B cell development, respectively. Recent thymic emigrants (RTEs) are a subset of peripheral cells that may also represent thymic function. Here, we investigated TREC/KREC copy numbers by quantitative real-time PCR in the peripheral blood of patients with primary immunodeficiencies (PIDs, n = 145) and that of healthy controls (HCs, n = 86) and assessed the correlation between RTEs and TREC copy numbers. We found that TREC copy numbers were significantly lower in children and adults with PIDs (P < .0001 and P < .002, respectively) as compared with their respective age-matched HCs. A moderate correlation was observed between TREC copies and RTE numbers among children with PID (r = .5114, P < .01), whereas no significant correlation was detected between RTE values and TREC content in the HCs (r = .0205, P = .9208). Additionally, we determined TREC and KREC copy numbers in DNA isolated from the Guthrie cards of 200 newborns and showed that this method is applicable to DNA isolated from both peripheral blood samples and dried blood spots, with the two sample types showing comparable TREC and KREC values. We further showed that RTE values are not always reliable markers of T cell output. Although additional confirmatory studies with larger cohorts are needed, our results provide thresholds for TREC/KREC copy numbers for different age groups.
  • Publication
    Predictors of positive response to beta-blockers for treatment of premature ventricular complexes
    (CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2022) Demir, Serdar; Gulsen, Kamil; Kepez, Alper; Uslu, Abdulkadir; Kup, Ayhan; Celik, Mehmet; Kanar, Batur Gonenc; Yildirim, Cagan; Tulumen, Erol; Akgun, Taylan
    Background: The aim of the present study is to investigate the possible factors that might be predictive of effective antiarrhythmic effect of beta-blockers on premature ventricular complexes (PVC). Methods: Data of 190 eligible consecutive patients to whom beta-blocker therapy had been initiated for treatment of PVC's were retrospectively evaluated. The Holter recording acquired before beta-blocker initiation and the first Holter acquired after beta blocker initiation during follow up was comprehensively evaluated for each patient. Parameters obtained from pre- and post-beta-blocker 24 h Holter recordings were compared with each other and possible predictors were evaluated for positive response to beta-blocker therapy. Results: Sixty-one patients (32.1%) were observed to respond beta-blocker therapy with at least 50% reduction of daily PVC burden. Patients who responded to beta-blockers had significantly higher ratio of patients who had positive correlation between hourly heart rate and corresponding hourly PVC number (fast HR-PVC status) compared with non-responders (73.8% vs 48.1%, p < 0.001). Binary logistic regression analysis revealed PVC QRS width (Odds ratio: 0.971; p: 0.037) and fast HR-PVC status (Odds ratio: 2.935; p: 0.007) as the independent predictors of positive response to beta-blockers for treatment of PVC. Conclusion: Positive correlation between hourly heart rate and PVC incidence was found to be independent positive predictor and PVC QRS width was found to be independent negative predictor of beta-blocker success in our study. This observation might have important clinical implications to guide medical treatment of PVCs in clinical practice.
  • Publication
    Effects on Turkish ice cream employees' musculoskeletal pain of a physical activity and ergonomics improvement program in the workplace
    (TAYLOR & FRANCIS LTD, 0) Yalcin, Ilknur; Ergun, Ayse
    Objectives. This study aimed to investigate the effects of a physical activity and ergonomics improvement program (PAEIP) on employees' musculoskeletal pain. Methods. The sampling group included 120 employees who met the criteria and were randomly assigned to the intervention group (n = 57) and the control group (n = 63). The visual analog scale, the Nordic musculoskeletal survey and rapid upper limb assessment (RULA) were used for collecting data. Results. When pre-test and post-test pain scores of the intervention group were compared, the average post-test scores were significantly lower in the neck, shoulder, wrist and lower back regions than the pre-test scores. When the intervention and control group RULA scores were compared, in the intervention group the proportion of employees found in an 'acceptable posture' level was 0% in the pre-test and 5.3% in the post-test, and in the same group the proportion of employees in the 'further investigation and change may be needed' level was 31.6% in the pre-test and increased to 61.4% in the post-test. Conclusion. As a result, the PAEIP has been found effective in reducing the ergonomic risks associated with upper extremities and rate or intensity of musculoskeletal pain.
  • Publication
    The Immediate Adverse Events of Lumbar Interventional Pain Procedures in 4,209 Patients: An Observational Clinical Study
    (OXFORD UNIV PRESS, 2022) Sencan, Savas; Sacaklidir, Rekib; Gunduz, Osman Hakan
    Objective. Lumbar interventional pain procedures (LIPPs) are frequently used in low back pain and have shown an increasing trend in recent years. LIPPs are highly effective when performed by properly trained physicians. However, some adverse events are seen during interventional procedures. Our aim in this study is to determine the immediate adverse event rates of LIPPs and to inform our colleagues about possible adverse events. Study Design. Retrospective, observational study. Setting. A university hospital pain management center. Methods. After approval by the institutional ethics committee, a retrospective evaluation of patients who received fluoroscopy-guided LIPPs between January 2015 and December 2020 was performed. This observational study was conducted with 4,209 patients who underwent LIPPs, including epidural steroid injection, sacroiliac and facet joint injection, medial branch block or radiofrequency ablation, application of pulsed radiofrequency to the dorsal root ganglion, epidural catheter placement, or spinal cord stimulator application. Results. No major adverse events were detected during the procedures. Minor adverse events were detected in 60 patients, and the adverse events rate was found to be 1.4% (95% confidence interval: 1.0-1.8%). Minor adverse events rates varied between 0.7% and 2.3% according to the procedure type. The most common adverse events were determined to be vasovagal reactions (26/60). Facial numbness, cramps, and seizures were detected as rare adverse events. Conclusion. No major adverse events were seen in 4,209 patients. The rate of minor adverse events was 1.4%, with no sequelae in any of the events. When evidence-based guidelines are followed, interventional pain procedures can be performed safely.