Publication:
11 beta-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease

Simple item page
dc.contributor.authorsAtalar, F.; Vural, B.; Ciftci, C.; Demirkan, A.; Akan, G.; Susleyici-Duman, B.; Gunay, D.; Akpinar, B.; Sagbas, E.; Ozbek, U.; Buyukdevrim, A. S.
dc.date.accessioned2022-03-14T10:53:25Z
dc.date.available2022-03-14T10:53:25Z
dc.date.issued2012
dc.description.abstract11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11 beta-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the development of coronary atherosclerosis. The 11 beta-HSD-1 expression was evaluated by qRT-PCR in EA and AA tissues of 20 metabolic syndrome patients with coronary artery disease (metabolic syndrome group) and 10 non-metabolic syndrome patients without coronary artery disease (controls). 11 beta-HSD-1 expression was increased in EA and AA tissues of the metabolic syndrome group (4.1-and 5.5-fold, respectively). A significant positive correlation was found between 11 beta-HSD-1 expression in EA tissue and waist hip ratio and 11 beta-HSD-1 expression in AA tissue and body mass index, while a negative correlation was found between 11 beta-HSD-1 expression in EA tissue and HDL. Expression of CD68, a macrophage marker, was significantly increased in both tissues of the metabolic syndrome group; it was 2-fold higher in AA tissue compared to EA tissue in the metabolic syndrome group. Our findings of increased expression of 11 beta-HSD-1 and CD68 in AA tissue of the metabolic syndrome group lead us to suggest that they contribute to coronary atherosclerosis in metabolic syndrome. This positive correlation between obesity markers and 11 beta-HSD-1 in AA and EA tissues strengthens the evidence that 11 beta-HSD-1 has a role in metabolic syndrome. To the best of our knowledge, this is the first report showing 11 beta-HSD-1 and CD68 expression in AA tissue of metabolic syndrome patients. We suggest that there is tissue-specific expression of 11 beta-HSD-1 in metabolic syndrome and associated cardiovascular disorders.
dc.identifier.doi10.4238/2012.August.31.10
dc.identifier.issn1676-5680
dc.identifier.pubmed23007990
dc.identifier.urihttps://hdl.handle.net/11424/245321
dc.identifier.wosWOS:000308817800133
dc.language.isoeng
dc.publisherFUNPEC-EDITORA
dc.relation.ispartofGENETICS AND MOLECULAR RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject11 beta-hydroxysteroid dehydrogenase type 1
dc.subjectAscending aorta
dc.subjectGlucocorticoids
dc.subjectEpicardial adipose tissue
dc.subjectMetabolic syndrome
dc.subjectCoronary artery disease
dc.subjectEPICARDIAL ADIPOSE-TISSUE
dc.subjectDIET-INDUCED OBESITY
dc.subjectSTROMAL CELLS
dc.subjectIN-VIVO
dc.subjectFAT
dc.subjectDIFFERENTIATION
dc.subjectHEART
dc.subjectMICE
dc.subjectATHEROSCLEROSIS
dc.subjectINFLAMMATION
dc.title11 beta-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id0ed2ddcf-5ea1-4211-b410-01e11d8f3c0a
local.import.packageSS16
local.indexed.atWOS
local.journal.numberofpages11
oaire.citation.endPage3132
oaire.citation.issue3
oaire.citation.startPage3122
oaire.citation.titleGENETICS AND MOLECULAR RESEARCH
oaire.citation.volume11

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Atalar et al. - 2012 - 11β-hydroxysteroid dehydrogenase type 1 gene expre.pdf
Size:
522.65 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs