Publication:
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis

dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsRobson J. C., Grayson P. C., Ponte C., Craven A., Khalid S., Judge A., Hutchings A., Merkel P. A., Luqmani R. A., Watts R. A., et al.
dc.date.accessioned2023-11-20T08:29:17Z
dc.date.available2023-11-20T08:29:17Z
dc.date.issued2022-03-01
dc.description.abstractObjective: To develop and validate classification criteria for microscopic polyangiitis (MPA). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate items using consensus methodology, 2) prospective collection of candidate items present at the time of diagnosis, 3) data-driven reduction of the number of candidate items, 4) expert panel review of cases to define the reference diagnosis, and 5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators. Results: The development set for MPA consisted of 149 cases of MPA and 408 comparators. The validation set consisted of an additional 142 cases of MPA and 414 comparators. From 91 candidate items, regression analysis identified 10 items for MPA, 6 of which were retained. The final criteria and their weights were as follows: perinuclear antineutrophil cytoplasmic antibody (ANCA) or anti–myeloperoxidase-ANCA positivity (+6), pauci-immune glomerulonephritis (+3), lung fibrosis or interstitial lung disease (+3), sino-nasal symptoms or signs (−3), cytoplasmic ANCA or anti–proteinase 3 ANCA positivity (−1), and eosinophil count ≥1 × 109/liter (−4). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having MPA with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the sensitivity was 91% (95% confidence interval [95% CI] 85–95%) and the specificity was 94% (95% CI 92–96%). Conclusion: The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for MPA are now validated for use in clinical research.
dc.identifier.citationRobson J. C., Grayson P. C., Ponte C., Craven A., Khalid S., Judge A., Hutchings A., Merkel P. A., Luqmani R. A., Watts R. A., et al., "2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis", Arthritis and Rheumatology, cilt.74, sa.3, ss.400-406, 2022
dc.identifier.doi10.1002/art.41983
dc.identifier.endpage406
dc.identifier.issn2326-5191
dc.identifier.issue3
dc.identifier.startpage400
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/5f97f6e4-3ad9-41a7-860e-9810895e2278/file
dc.identifier.urihttps://hdl.handle.net/11424/294982
dc.identifier.volume74
dc.language.isoeng
dc.relation.ispartofArthritis and Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectİmmünoloji
dc.subjectALERJİ
dc.subjectROMATOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectIMMUNOLOGY
dc.subjectALLERGY
dc.subjectRHEUMATOLOGY
dc.subjectİmmünoloji ve Alerji
dc.subjectRomatoloji
dc.subjectImmunology and Allergy
dc.subjectRheumatology
dc.subjectImmunology
dc.title2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id5f97f6e4-3ad9-41a7-860e-9810895e2278
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscovery07a34d26-21f3-475d-bd36-152d6c659370

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