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5-fluorouracil-loaded chitosan microspheres: Preparation and release characteristics

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dc.contributor.authorsAkbuga, J; Bergisadi, N
dc.date.accessioned2022-03-12T16:57:04Z
dc.date.available2022-03-12T16:57:04Z
dc.date.issued1996
dc.description.abstractCross-linked chitosan microspheres containing 5-Fluorouracil (5-FU) were prepared. Variables believed to be important for microsphere properties were examined; these included: drug and chitosan concentrations, cross-linking process, the type of oil, stirring rate and also additives. Initial 5-FU concentration, the type and concentration of chitosan, the viscosity of oil phase and glutaraldehyde concentration affected drug release from chitosan microspheres. 5-FU release from cross-linked chitosan microspheres is characterized by an initial rapid release of drug. Addition of substances such as alginic acid, chitin, agar, sodium caprylate and stearic acid changed the release properties of 5-FU microspheres.
dc.identifier.doi10.3109/02652049609052904
dc.identifier.issn0265-2048
dc.identifier.pubmed8999121
dc.identifier.urihttps://hdl.handle.net/11424/226874
dc.identifier.wosWOS:A1996UC38800004
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofJOURNAL OF MICROENCAPSULATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject5-fluorouracil
dc.subjectchitosan
dc.subjectmicrosphere
dc.subjectdrug release
dc.title5-fluorouracil-loaded chitosan microspheres: Preparation and release characteristics
dc.typearticle
dspace.entity.typePublication
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage168
oaire.citation.issue2
oaire.citation.startPage161
oaire.citation.titleJOURNAL OF MICROENCAPSULATION
oaire.citation.volume13

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