Publication: Predictors of positive response to beta-blockers for treatment of premature ventricular complexes
dc.contributor.authors | Demir, Serdar; Gulsen, Kamil; Kepez, Alper; Uslu, Abdulkadir; Kup, Ayhan; Celik, Mehmet; Kanar, Batur Gonenc; Yildirim, Cagan; Tulumen, Erol; Akgun, Taylan | |
dc.date.accessioned | 2022-04-25T00:12:14Z | |
dc.date.available | 2022-04-25T00:12:14Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: The aim of the present study is to investigate the possible factors that might be predictive of effective antiarrhythmic effect of beta-blockers on premature ventricular complexes (PVC). Methods: Data of 190 eligible consecutive patients to whom beta-blocker therapy had been initiated for treatment of PVC's were retrospectively evaluated. The Holter recording acquired before beta-blocker initiation and the first Holter acquired after beta blocker initiation during follow up was comprehensively evaluated for each patient. Parameters obtained from pre- and post-beta-blocker 24 h Holter recordings were compared with each other and possible predictors were evaluated for positive response to beta-blocker therapy. Results: Sixty-one patients (32.1%) were observed to respond beta-blocker therapy with at least 50% reduction of daily PVC burden. Patients who responded to beta-blockers had significantly higher ratio of patients who had positive correlation between hourly heart rate and corresponding hourly PVC number (fast HR-PVC status) compared with non-responders (73.8% vs 48.1%, p < 0.001). Binary logistic regression analysis revealed PVC QRS width (Odds ratio: 0.971; p: 0.037) and fast HR-PVC status (Odds ratio: 2.935; p: 0.007) as the independent predictors of positive response to beta-blockers for treatment of PVC. Conclusion: Positive correlation between hourly heart rate and PVC incidence was found to be independent positive predictor and PVC QRS width was found to be independent negative predictor of beta-blocker success in our study. This observation might have important clinical implications to guide medical treatment of PVCs in clinical practice. | |
dc.identifier.doi | 10.1016/j.jelectrocard.2021.11.036 | |
dc.identifier.eissn | 1532-8430 | |
dc.identifier.issn | 0022-0736 | |
dc.identifier.pubmed | 34922221 | |
dc.identifier.uri | https://hdl.handle.net/11424/264045 | |
dc.identifier.wos | WOS:000746079700013 | |
dc.language | eng | |
dc.publisher | CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS | |
dc.relation.ispartof | JOURNAL OF ELECTROCARDIOLOGY | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Premature ventricular complex | |
dc.subject | Beta-blocker | |
dc.subject | Holter recording | |
dc.subject | Diurnal variability of premature ventricular | |
dc.subject | complexes | |
dc.subject | COUPLING INTERVAL VARIABILITY | |
dc.subject | HEART-RATE | |
dc.subject | CONTRACTIONS | |
dc.subject | SUPPRESSION | |
dc.subject | SLEEP | |
dc.title | Predictors of positive response to beta-blockers for treatment of premature ventricular complexes | |
dc.type | article | |
dspace.entity.type | Publication | |
local.avesis.id | aa107a98-664d-4a0e-95ed-ca2628db49b1 | |
local.import.package | SS39 | |
local.indexed.at | WOS | |
local.journal.numberofpages | 6 | |
oaire.citation.endPage | 55 | |
oaire.citation.startPage | 50 | |
oaire.citation.title | JOURNAL OF ELECTROCARDIOLOGY | |
oaire.citation.volume | 70 |