Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats

KARĞIN, DİCLEYAVUZ, AYŞE NURÇAM, MUHAMMET EMİNAKTAÇ, ŞULE2023-02-072023-02-072023-02-01Karğın D., Aktaç Ş., Yavuz A. N., Çam M. E., "Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats", JOURNAL OF RESEARCH IN PHARMACY, cilt.27, sa.1, ss.432-440, 20232630-6344https://jrespharm.com/uploads/pdf/pdf_MPJ_1204.pdfhttps://hdl.handle.net/11424/286019Cornelian cherry (Cornus mas L.) has been used for centuries as a traditional herbal medicine in Europe and Asia. In this study, we aimed to describe the effect of Cornus mas L. (C. mas) on the activity of the antioxidant enzymes and a detoxification agent in rats fed a high-fat diet. Forty-eight adult Sprague Dawley rats were randomly assigned to six groups of eight animals each: Standard diet (Control), High Fat Diet (HFD), HFD + C. mas (200 mg/kg/day; 8 weeks), HFD + Atorvastatin (20 mg/kg/day; 8 weeks), HFD post-treated with C. mas (200 mg/kg/day; 4 weeks), HFD posttreated with Atorvastatin (20 mg/kg/day; 4 weeks). The activity of the antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), detoxification agent glutathione (GSH), and oxidative stress parameter thiobarbituric acid reactive substances (TBARS) were measured in the liver tissues. GPx, SOD, and CAT enzyme levels were decreased in HFD groups compared to the control (p < 0.05). However, Cornus mas L. promoted antioxidant activity by increasing GPx, SOD, and CAT enzymes and It also reduced oxidative stress (as an increase in GSH) both in the HFD + C. mas group and the HFD post-treated C. mas group compared to the HFD group (p < 0.05). Our study showed that feeding a high-fat diet increases oxidative stress. Cornus mas L treatment improves antioxidant enzyme activity and oxidative stress parameters in the liver tissues of rats.enginfo:eu-repo/semantics/openAccessBeslenme ve DietetikSağlık BilimleriNutrition and DieteticsHealth SciencesTarım ve Çevre Bilimleri (AGE)Klinik Tıp (MED)Tarım BilimleriBESLENME VE DİYETETİKAgriculture & Environment Sciences (AGE)Clinical Medicine (MED)AGRICULTURAL SCIENCESNUTRITION & DIETETICSBeslenme ve DiyetetikCornus mas L.liverantioxidantglutathionehigh-fat-dietEffects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed ratsarticle27143244010.29228/jrp.325