ŞEN YAVUZ, BETÜLYILMAZ, MÜESSER AHUOKTAY, NİHAL ŞEHKARKARGÜL, BETÜL2022-12-282022-12-282022-04-01Yildiz P. K., ŞEN YAVUZ B., YILMAZ M. A., OKTAY N. Ş., KARGÜL B., "THE EFFECT OF A SINGLE APPLICATION OF DIFFERENT FLUORIDE VARNISHES ON ENAMEL SUBSURFACE LESIONS IN VITRO", FLUORIDE, cilt.55, sa.2, ss.121-130, 20220015-4725https://www.webofscience.com/wos/woscc/full-record/WOS:000888257000004https://hdl.handle.net/11424/284424This in vitro study aimed to evaluate the therapeutic effect of different fluoride ion (F) varnish formulations for controlling the carious development of enamel subsurface lesions and the F release into artificial saliva for 2 hr, 24 hr, 48 hr, and 7 days. Artificial enamel carious lesions were created and divided into 6 groups (5 varnish groups and a control group). Varnishes were applied to enamel specimens and then the specimens were incubated in artificial saliva, with the artificial saliva replenished daily. Varnish was removed and lesions were remineralized in artificial saliva for 24 hr. Surface microhardness was measured three times: (i) initially, (ii) after creating the artificial enamel lesions, and (iii) after applying the varnishes. The F release was analyzed after 2 hr, 24 hr, 48 hr, and 7 days of exposure using an ion-selective electrode. Data were analyzed using a One-way Analysis of Variance with the Tukey-Kramer Multiple Comparisons test and the Kruskal-Wallis test with the Dunns Multiple Comparisons test. The highest percentage surface microhardness recovery was found for the treatment with the MI Varnish. According to the percentage surface microhardness recovery results, a statistically significant difference was found between the varnishes and the control group (p < 0.05 and < 0.001). All varnishes released measurable levels of fluoride ions. However, the release of F was the highest in the MI Varnish group (p < 0.01). Duraphat, Enamel Pro Varnish, and MI Varnish released the most F into artificial saliva. Calcium phosphate-based F varnishes improve the capacity of the enamel surface re -hardening. CPP containing F varnish had the highest release of F as compared to the other F releasing varnishes. Further in vivo investigations are also required to prove the clinical applications of the different ingredients containing varnishes.enginfo:eu-repo/semantics/closedAccessEczacılıkMeslek BilimleriFarmasötik ToksikolojiSosyal ve Beşeri BilimlerSosyolojiYaşam BilimleriSağlık BilimleriTemel BilimlerPharmacology and TherapeuticsProfessional SciencesPharmaceutical ToxicologySocial Sciences and HumanitiesSociologyLife SciencesHealth SciencesNatural SciencesKAMU, ÇEVRE VE İŞ SAĞLIĞISosyal Bilimler GenelSosyal Bilimler (SOC)TOKSİKOLOJİFarmakoloji ve ToksikolojiYaşam Bilimleri (LIFE)PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTHSOCIAL SCIENCES, GENERALSocial Sciences (SOC)TOXICOLOGYPHARMACOLOGY & TOXICOLOGYLife Sciences (LIFE)İş Sağlığı ve TerapisiGüvenlik AraştırmasıSağlık (sosyal bilimler)Genel Sosyal BilimlerToksikolojiFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)Halk, Çevre ve İş SağlığıEpidemiyolojiSağlık, Toksikoloji ve MutajenezFizik BilimleriSosyal Bilimler ve Beşeri BilimlerOccupational TherapySafety ResearchHealth (social science)General Social SciencesToxicologyPharmacology, Toxicology and Pharmaceutics (miscellaneous)Public Health, Environmental and Occupational HealthEpidemiologyHealth, Toxicology and MutagenesisPhysical SciencesSocial Sciences & HumanitiesCPP-ACPDemineralizationFluoride releaseFluoride varnishesMicrohardnessRemineralizationTricalcium phosphatearticle552121130