DOĞAN, AHMETŞEN, ALİBİTİŞ, LEYLA2022-03-122022-03-1220191041-2905https://hdl.handle.net/11424/235644The essential oil of aerial parts of Stachys subnuda Montbret & Aucher ex Benth (S. subnuda) was analyzed by gas chromatography (GC) and GC/mass spectrometry (MS). Anti-inflammatory activity was evaluated by lipoxygenase inhibition assay. The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid (ABTS) assays. Sixty-two constituents, comprising 97.1% of the total essential oil composition, were identified. Phytol (25.2%), beta-caryophyllene (11.2%), germacrene D (6.9%), and hexadecanoic acid (6.9%) were the major compounds of aerial part essential oils of S. subnuda. The essential oil showed significant radical scavenging activity with 50% inhibition (IC50) values of 0.124 and 0.204 mg/mL for ABTS and DPPH radicals, respectively. The essential oil exhibited moderate anti-inflammatory activity with an IC50 value of 0.419 mg/mL. The results indicated that S. subnuda essential oil had good anti-inflammatory and antioxidant activity. Also, this is first study on chemical composition, anti-inflammatory and antioxidant activity of S. subnuda essential oil.enginfo:eu-repo/semantics/closedAccessStachys subnudaessential oilanti-inflammatory activityantioxidant activityVOLATILE CONSTITUENTSBETA-CARYOPHYLLENEPHYTOCHEMICAL ANALYSISBIOLOGICAL-ACTIVITIESANTICANCER ACTIVITYDIFFERENT REGIONSCENTRAL APENNINESRECH. FIL.L.LAMIACEAEarticleWOS:00046349810000110.1080/10412905.2019.15673992163-8152