İŞAK, BARIŞ2022-03-122022-03-1220151388-2457https://hdl.handle.net/11424/233486Objective: To investigate the cutaneous silent period (CSP), a spinal inhibitory reflex mainly mediated by A-delta fibres, in demyelinating and axonal polyneuropathy (PNP) and evaluate whether CSP parameters differ between patients with and without neuropathic pain. Methods: Eighty-four patients with demyelinating PNP, 178 patients with axonal PNP and 265 controls underwent clinical examination, DN4 questionnaire, standard nerve conduction study, motor-root stimulation and CSP recordings from abductor digiti minimi. We calculated the afferent conduction time of CSP (a-CSP time) with the formula: CSP latency - root motor evoked potential latency. Results: In the demyelinating PNP group the a-CSP time was significantly longer; in the axonal PNP group, CSP duration was shorter than the demyelinating group (p = 0.010) and controls (p = 0.001). CSP parameters were not different between patients with and without neuropathic pain. Conclusions: The abnormality of a-CSP time in the demyelinating PNP group suggests the crucial role of A-delta fibres in the mechanism of CSP; the shorter CSP duration in the axonal PNP group supports the strong influence of the number of axons on this parameter. Conclusions: Our study suggests that neuropathic pain could be related to pathophysiological mechanisms differing from mere A-delta fibre loss. Significance: CSP evaluation is effective in detecting A-delta fibre dysfunction in axonal as well as demyelinating PNP. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.enginfo:eu-repo/semantics/closedAccessCutaneous silent periodA-delta fibresAxonal polyneuropathyDemyelinating polyneuropathyNeuropathic painROCHESTER DIABETIC-NEUROPATHYF-WAVEEFNS GUIDELINESMIXED NERVEHAND MUSCLEPAINSTIMULATIONMOTORSENSITIVITYDIAGNOSISarticleWOS:00035931980002110.1016/j.clinph.2014.11.013254977131872-8952