ÖZDEMİR KUMRAL, ZARİFE NİGARYÜKSEL, MERALAKAKIN, DİLEKERZİK, CANHAKLAR, GONCAGÜL2022-10-102022-10-102022-09-01ÖZDEMİR KUMRAL Z. N. , Sen E., Yapici H. B. , Atakul N., Domruk O. F. , Aldag Y., Sen L. S. , Mustafaoglu F. K. , YÜKSEL M., AKAKIN D., et al., "Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden", JOURNAL OF PHARMACY AND PHARMACOLOGY, 20220022-3573https://hdl.handle.net/11424/282251Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol/kg, or 45 nmol/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and beta cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.enginfo:eu-repo/semantics/openAccessTemel Eczacılık BilimleriEczacılıkYaşam BilimleriSağlık BilimleriTemel BilimlerBasic Pharmaceutics SciencesPharmacology and TherapeuticsLife SciencesHealth SciencesNatural SciencesFARMAKOLOJİ VE ECZACILIKFarmakoloji ve ToksikolojiYaşam Bilimleri (LIFE)PHARMACOLOGY & PHARMACYPHARMACOLOGY & TOXICOLOGYLife Sciences (LIFE)FarmakolojiFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)Genel Farmakoloji, Toksikoloji ve EczacılıkFarmakoloji (tıbbi)İlaç RehberleriPharmacyPharmacologyPharmacology, Toxicology and Pharmaceutics (miscellaneous)General Pharmacology, Toxicology and PharmaceuticsPharmacology (medical)Drug Guidesinflammationinsulingastric emptyingglucosefree radicalsMPOORAL GLUCOSE-TOLERANCEPEPTIDETESTOSTERONEMODULATIONNESFATIN-1EXPRESSIONSECRETIONSTRESSDAMAGESITESinflammationinsulingastric emptyingglucosefree radicalsMPOarticle10.1093/jpp/rgac055