ŞAHİN, ÖZLEMSEVİK, MEHMET ORKUNÇAM, FURKANDERİCİOĞLU, VOLKAN2023-08-212023-08-212023-01-01SEVİK M. O., Aykut A., ÇAM F., DERİCİOĞLU V., ŞAHİN Ö., "Choroidal vascularity index as an activity criterion and a treatment response measure in chronic central serous chorioretinopathy", Ophthalmic and Physiological Optics, 20230275-5408https://onlinelibrary.wiley.com/doi/epdf/10.1111/opo.13187https://hdl.handle.net/11424/292733Purpose: This study aimed to evaluate the choroidal vascularity index (CVI) as an activity criterion in chronic central serous chorioretinopathy (CSC) and as a measure of treatment response after full-dose-full-fluence photodynamic therapy (fd-ff-PDT). Methods: This fellow-eye-controlled, retrospective cohort study included 23 patients with unilateral chronic CSC treated with fd-ff-PDT (6 mg/m2; 50 μcm2; 83 s). Subfoveal choroidal thickness (SFCT, μm) and CVI (%) of the affected and fellow eyes at baseline as well as at 1, 3 and 6 months after fd-ff-PDT were compared. Results: The patients\" mean age was 43.4 ± 7.3 years, and 18 (78.3%) were male. CVI was comparable between the affected and fellow eyes at baseline (66.09 ± 1.56 vs. 65.84 ± 1.57, p = 0.59). However, it became significantly lower in the affected eyes 1 (64.45 ± 1.68 vs. 65.87 ± 1.19, p = 0.002), 3 (64.21 ± 2.08 vs. 65.71 ± 1.59, p = 0.009) and 6 (64.47 ± 2.19 vs. 65.62 ± 1.52, p = 0.045) months after fd-ff-PDT. The mean SFCT and the mean CVI were significantly decreased in the affected eyes at all follow-up visits compared with baseline after fd-ff-PDT (p < 0.001). Conclusion: At baseline, CVI was comparable between affected and fellow eyes. Therefore, its use as an activity criterion in chronic CSC patients is questionable. However, it was significantly decreased in fd-ff-PDT-treated eyes, supporting its role as a measure of treatment response in chronic CSC.enginfo:eu-repo/semantics/openAccessTıpCerrahi Tıp BilimleriGöz Hastalıkları ve CerrahisiYaşam BilimleriSağlık BilimleriTemel BilimlerMedicineSurgery Medicine SciencesEye Diseases and SurgeryLife SciencesHealth SciencesNatural SciencesKlinik Tıp (MED)Yaşam Bilimleri (LIFE)Klinik TıpSinirbilim ve DavranışGÖZ HASTALIKLARISİNİR BİLİMİClinical Medicine (MED)Life Sciences (LIFE)CLINICAL MEDICINENEUROSCIENCE & BEHAVIOROPHTHALMOLOGYNEUROSCIENCESOftalmolojiOptometriDuyusal SistemlerOphthalmologyOptometrySensory Systemscentral serous chorioretinopathychoroidal vascularity indexsubfoveal choroidal thicknessarticle10.1111/opo.13187