KEPENEKLİ KADAYİFCİ, EDA2023-07-252023-07-252021-11-01Demir S. O., KEPENEKLİ KADAYİFCİ E., Akkoc G., Yakut N., Soysal A., "Cost and length of hospital stay for healthcare facility-onset Clostridioides Difficile infection in pediatric wards: a prospective cohort analysis", TURKISH JOURNAL OF PEDIATRICS, cilt.63, sa.6, ss.1004-1011, 20210041-4301https://www.turkishjournalpediatrics.org/uploads/pdf_TJP_2378.pdfhttps://hdl.handle.net/11424/291535Background. Clostridioides difficile (C. difficile) is a well-known causative agent of healthcare associated infection, it increases medical cost besides increasing morbidity and mortality. This study was conducted to determine the incidence, and economic burden of healthcare facility-onset C. difficile infection (HO-CDI) in children. Methods. Data was acquired with a prospective cohort study conducted in pediatric wards of a tertiary university hospital between August 2015 to August 2016. The HO-CDI was defined as diarrhea that began after 48 hours of admission with a positive cytotoxic stool assay for the presence of toxin A and/or B of C. difficile. Results. In the 3172 admissions in one year, 212 (7%) healthcare associated diarrhea (HAD) episodes were observed, in 25 (12%) of them C. difficile was identified in which 6 (25%) cases <2-year-old. The incidence of HOCDI was estimated as 8.8/10,000 patient-days. Cases with HO-CDI (n=19) were compared with cases with nonCDI-HAD (n=102); the presence of one of the risk factors for CDI increased the risk for HO-CDI (5,05; 95% Cl: 1.10-23.05; P 0,037), the median length of stay (LOS) attributable HO-CDI was 7 days (IQR,5-10) per admission, whereas for non-CDI-HAD was 2 days (IQR,0-4) (p=0.036). General hospitalization costs in the two groups were similar, specifically estimated costs attributable to HO-CDI and non-CID-HAD were $294.0 and $137.0 per Conclusion. Although in children the incidence of HO-CDI is increasing, its clinical manifestation is still milder and effective infection control measures with antibiotic stewardship can limit related morbidly, mortality, LOS, and cost.enginfo:eu-repo/semantics/openAccessTıpDahili Tıp BilimleriÇocuk Sağlığı ve HastalıklarıSağlık BilimleriMedicineInternal Medicine SciencesChild Health and DiseasesHealth SciencesPEDİATRİKlinik TıpKlinik Tıp (MED)PEDIATRICSCLINICAL MEDICINEClinical Medicine (MED)PediatriPediatri, Perinatoloji ve Çocuk SağlığıPediatricsPediatrics, Perinatology and Child Healthhealth-careHO-CDICdifficilecostpediatricRISK-FACTORSCHILDRENBURDENCOLONIZATIONDISEASEhealth-careHO-CDIC. difficilecostpediatricarticle6361004101110.24953/turkjped.2021.06.008