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Publication Metadata only 1,2,4-triazole-5(4H)-one based novel peripherally tetrasubstituted metal-free and metallophthalocyanines: Synthesis, characterization, and electrochemical and spectroelectrochemical properties(TAYLOR & FRANCIS INC, 2017) KOCA, ATIF; Aktas, Ayse; Uenlueer, Dilek; Kobak, Rabia Zeynep Uslu; Acar, Irfan; Dugdu, Esra; Koca, Atif; Kantekin, HalitIn this study, the synthesis of metal-free and metallophthalocyanines containing four 4-[2-(4-methoxyphenyl) ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one substituents at the peripheral positions were reported. The structures of compounds were characterized using IR, H-1 NMR, C-13 NMR, mass spectroscopies, and UV-Vis. Electrochemistry of the complexes were studied with voltammetric and in situ spectroelectrochemical measurements in different electrolytic systems. MPcs having redox inactive metal centers (H+, Zn+2, Cu+2, and Ni+2) just illustrated similar Pc-based electron transfer reactions. Due to the different effective nuclear charge of the ions in the core of Pc ring, small potential shifts and reversibility differences were observed between the redox processes of these complexes. MPcs having redox-active metal centers (Co+2 and TiO+2) gave metal-based electron transfers in addition to Pc-based processes. Electrolyte type of the measurement system significantly influenced oxidation behaviors of CoPc due to the coordination of polar coordinating solvent molecules to the oxidized Co-III center of CoPc. Spectra and color of the electrogenerated MPc species were determined with in situ spectroelectrochemical measurements.Publication Open Access -174 G/C polymorphism of interleukin 6 gene is not significantly different in Turkish professional short and long distance runners(C M B ASSOC, 2018-08-30) Arica, Secil; Solgun, Huscyin Avni; Dengi, Ayse Seda Demirel; Bakmaz, Enver; Akcays, Teoman; Kapici, Sezgin; Sercan, Canan; Ulucan, KorkutInterleukin-6 (IL-6) is a kind of multifunctional cytokine and involved in mediating muscle repair metabolism, and therefore athletic capacity. Muscular and circulating IL-6 levels increase in response to physical exercise. Responsible gene coding for IL-6 has a functional polymorphism in its promoter region, -174 G/C (rs1800795). We aimed to analyze the association of G allele and GG genotype in Turkish professional athletes and compare the allelic and genotypic difference between short distance and long distance runners. For this purpose, we enrolled 40 (24 short distance runners and 16 long distance runners) Turkish professional athletes to the study. Real time genotyping procedure was carried out to determine the -174 G/C polymorphism. G allele and GG genotype was more prevalent than the others in our cohort. We found no statistically significant difference between short and long distance runners in the terms of genotype (p-0.07). Our study suggests that-174 G/C polymorphism of IL-6 gene differs in athletes, G allele and GG genotype is higher than the other ones, at least in Turkish athletes. and therefore should be taken into consideration when determining genetic aspects of athletes. Further studies arc necessary to confirm our results and show the effect of the given polymorphism in sports science.Publication Metadata only (2, J)-IDEALS IN COMMUTATIVE RINGS(PUBL HOUSE BULGARIAN ACAD SCI, 2020) Yildiz, Eda; Tekir, Unsal; Koc, SuatLet A be a commutative ring with nonzero identity. In this paper, we introduce the concept of (2, J)-ideal as a generalization of J-ideal. A proper ideal P of A is said to be a (2, J)-ideal if whenever abc is an element of P and a, b, c is an element of A, then ab is an element of P or ac is an element of Jac(A) or be is an element of Jac(A). Various examples and characterizations of (2, J)-ideals are given. Also, we study many properties of (2, J)-ideals and use them to characterize certain classes of rings such as quasi-local rings and Artinian rings.Publication Open Access 3d virtual modelling of existing objects by terrestrial photogrammetric methods - case study of barutana(UNIV OSIJEK, TECH FAC, 2017-05) Pejic, Petar; Krasic, Sonja; Krstic, Hristina; Dragovic, Magdalena; Akbiyik, YagizThree dimensional virtual modelling of existing objects (buildings or structures) is applicable in various fields of science and practice: architecture, civil engineering, urbanism, geology, mechanical engineering, video games and movie industry, medicine, archeology, safety of people and goods, etc. Photogrammetry, as a method of obtaining data of three-dimensional spatial structures based on two-dimensional images, is used, thanks to a number of software packages, for creating 3D models of objects and other spatial structures. This study analyses terrestrial semiautomatic and automatic photogrammetric methods, both presented through process of creating 3D model of an old existing historical building - Barutana (military gun powder warehouse), built in Ottoman empire, located in the fortress of the city of Nis in Serbia. The aim of the paper is comparison of two photogrammetric methods - semiautomatic and automatic in accuracy and efficiency through case study of Barutana.Publication Open Access A 12-month, Open Label, Multicenter Pilot Study Evaluating Fingolimod Treatment in terms of Patient Satisfaction in Relapsing Remitting Multiple Sclerosis Patients FINE Trial(AVES, 2017-06-20) Akman Demir, Gulsen; Turkoglu, Recai; Saip, Sabahattin; Yuceyar, Nur; Efendi, Husnu; Turan, Omer Faruk; Agan, Kadriye; Terzi, Murat; Boz, Cavit; Tuncer, Asli; Kocer, Belgin; Kasap, Mithat; Caliskan, ZeynepIntroduction: To assess satisfaction and quality of life in patients with relapsing-remitting multiple sclerosis (RRMS) who were receiving fingolimod (0.5 mg/day) for 12 months as a second-line treatment after switching from injectable agents. Methods: Patients aged 18-65 years with RRMS who fulfilled the eligibility criteria were enrolled from 16 centers throughout Turkey. Treatment Satisfaction Questionnaire for Medication and 36-item Short-Form Health Survey were completed at baseline and four visits to assess patient satisfaction and quality of life. Results: Forty-two patients (62% male; mean age: 35.7 +/- 9.4 years) were eligible for inclusion. Patient satisfaction scores at the end of the study 44.7 +/- 9.9) were significantly higher than those at baseline [32.0 +/- 9.9; (p<0.001)]. The only significant increase in the quality of life survey was in the emotional aspect (p=0.019). There were 124 adverse events and none of the five serious adverse events noted was considered drugrelated. Conclusion: Large-scale comparative studies performed with disease specific quality of life instruments will allow more information on this issue.Publication Open Access A 48-month randomized controlled trial of caries prevention effect of a one-time application of glass ionomer sealant versus resin sealant(JAPANESE SOC DENTAL MATERIALS DEVICES, 2016) MENTEŞ, ALİ RECAİ; Haznedaroglu, Eda; Guner, Sirin; Duman, Canan; Mentes, AliThe aim of this study was to compare the caries prevention effectiveness, retention rates and the level of fluoride of saliva of a glass-ionomer sealant (GIS) with that of a resin-based sealant (RS). Eighty GIS and 80RS were placed on the first permanent molars in 40 children aged 7-10 years. Children were re-examined at 6, 12, 24, 36 and 48 months after the procedure. Saliva samples were collected before the sealant was applied and again at each appointment, and fluoride levels were measured. After 48 months, occlusal caries were seen in 4 and 12 teeth in GIS and RS groups respectively. There was a statistically significant difference in the fluoride levels of saliva between baseline and up to 12th month in GIS group. GISs presented effective prevention of caries development, even though the failure rate is higher when compared to the RSs. An increased salivary fluoride level due to GISs might be an additive effect on the prevention of dental caries.Publication Metadata only A case of conjunctival MALT lymphoma: successfully treated with solely extended rituximab therapy(SPRINGER, 2019) TOKER, AYŞE EBRU; Celiker, Hande; Toker, Ebru; Atagunduz, Isik KaygusuzPurposePrimary ocular adnexal lymphomas are cured by radiotherapyPublication Metadata only A case study of antiaromaticity: carbomethoxy cyclopropenyl anion(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2019) BLEDA, ERDİ ATA; Altun, Zikri; Bleda, Erdi Ata; Trindle, CarlThe simplest ideas of antiaromaticity refer to regular monocyclic systems and the eigenfunctions of the Huckel Hamiltonian for 4n pi electrons in such systems. The antiaromaticity is expressed in the energy penalty for such idealized systems relative to the Huckel energy for 2n noninteracting pi pairs. Observed systems seldom achieve the regular planar geometry assumed in this picture, owing to their ability to ease the antiaromaticity penalty by departures from the regular geometry and also by export of the 4n pi electrons' charge to substituents. In this report we estimate numerical values for the stabilization derived from such departures from the structure and the charge distribution of the idealized antiaromatic cyclopropenyl anion for a specific case, 3-dehydro-3-methyl carboxylate cyclopropenyl anion 1(-) using the thermochemical scheme CBSQB3 supplemented by CCSD(T) calculations. According to the isodesmic reaction, the anion 1(-) is destabilized by about 10-15 kcal/mol relative to the saturated 3-dehydro-3-methylcarboxylate cyclopropyl anion 2(-). We propose that the anion relieves a portion of the antiaromatic destabilization by (a) pyramidalization of one carbon of the ring, and (b) export of negative charge into the ester substituent. Both of these responses are expressed in the equilibrium structure of the anion. In the course of the study we estimate the acidity of several related anions and the enthalpy of formation of their neutral conjugate acids, and describe the interconversion of 1 to the dehydrotriafulvalene anion 3(-) by reaction with CO2. [GRAPHICS] .Publication Open Access A Circuit Design by Using an Infrared Sensor Transmitter and Pic16f628 to Measure the Pulse Rate of the Driver(SAGE PUBLICATIONS LTD, 2016-07) BULDU, ALİ; Buldu, Ali; Yildiz, KazimThis study involves a circuit which is made in order to prevent traffic accidents caused by tiredness of the driver and sleepiness. Infrared light emitting diode and infrared phototransistor are used to track driver's body values during vehicle driving. The pulse value, which can increase or decrease directly proportional to the heart rate, can be controlled with the help of this infrared light emitting diode and infrared phototransistor. Peripheral interface controller is used in the construction of the system. The blood pressure was transformed to an electronic signal with infrared receiver and infrared transmitter by checking the heartbeats. This electronic signal was processed with peripheral interface controller and the system was constructed. In application, the pulse rate of the driver is continuously measured, and these values are shown on a small display permanently. It is installed on a portable steering wheel which can be used in the automotive industry. The process of waking the driver up can be made by raising the voice of music and with the vibration of the seat.Publication Metadata only A community-based intervention programme on hormonal contraceptives: The utilisation of social networks(TAYLOR & FRANCIS INC, 2016) TOPUZOĞLU, AHMET; Hidiroglu, S.; Topuzoglu, A.; Onsuz, M. F.The aim of the study was to determine the effects of an intervention programme based on the utilisation of the social learning concept which is practised through social networks among adult women in a suburban population in Turkey. The study was performed in two disadvantaged neighbourhoods of Umraniye, Istanbul. One of the neighbourhoods served as the intervention while the other as the control group. In order to document the efficacy of the intervention, baseline and evaluation surveys were carried out in both neighbourhoods. The most widely known hormonal contraceptive method was oral contraceptives, while emergency contraceptives were determined as the least known methods. The improvement was higher for the least known methods. Education with peer groups is shown to be effective in improving the knowledge of women about contraception. Information transfer through peer groups should be used more frequently particularly for emergency contraception.Publication Metadata only A COMPARATIVE BIOGEOGRAPHICAL STUDY OF MYXOMYCETES IN FOUR DIFFERENT HABITATS OF EASTERN MEDITERRANEAN PART OF TURKEY(PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2016) Baba, Hayri; Zumre, Murat; Ozyigit, Ibrahim IlkerIn this study, Myxomycetes were collected from four different habitats of Hatay province of Turkey during 2010-2015, including Altinozu plateau, Belen Atik highland, Kirikhan Amik plain and Yayladagi Selcen Mountain. From identificated 1047 samples, 102 species were classified in 6 orders, 12 families and 28 genera. 27 species were obtained from natural environment while 114 species cultered by moist chamber technique. In addition, 61 species was obtained from both natural environment and moist chamber technique. Physarales is the highest proportion order (29.4%), followed by Trichiales (25.4%) and Stemonitales (24.5%). The total myxomycetes ratio of these three orders was determined as 79.4%. When samples from four different habitats compared in terms of substrate types, at three habitats, dominant species is lignicol Myxomycetes (65-85%), while at one habitat, corticol Myxomycetes (65%) is the dominant type. Arcyria cinerea, Comatricha ellae, Comatricha nigra, Echinostelium minutum and Stemonitopsis amoena is the most generous species at four areas. Moreover, morphological, chorological and ecological characteristics of Myxomycetes were discussed.Publication Metadata only A comparative study for the treatment of simple bone cysts of the humerus: open curettage and bone grafting either without instrumentation or with intramedullary nailing(LIPPINCOTT WILLIAMS & WILKINS, 2017) Erol, Buelent; Onay, Tolga; Topkar, Osman M.; Tokyay, Abbas; Aydemir, Ahmet N.; Okay, ErhanFunctional and radiographic outcomes, in addition to complication and reoperation rates of open curettage and grafting without instrumentation or with intramedullary nailing, in the treatment of simple bone cysts (SBCs) of the humerus were compared. Thirty-seven children [25 males, 12 females; median age=9.5 years (range, 3-17 years)] with humeral SBC were treated with curettage and grafting without instrumentation (group 1, 21 patients) or with intramedullary nailing (group 2, 16 patients). The pathological fracture rate was 85.7% in group 1 and 87.5 in group 2. The follow-up duration ranged from 26 to 85 months. The average last follow-up Musculoskeletal Tumor Society functional scores for groups 1 and 2 were 28.9 and 29.5 (P>0.05). Higher, but statistically insignificant (P>0.05), complete or significant partial radiographic healing rates were achieved in group 2 (100%) compared with group 1 (76.2%). The overall complication rate of the entire study population was 21.6% (19%; 4/21 in group 1; 25%; 4/16 in group 2). The reoperation rates for groups 1 and 2 were 9.5% (2/21; one for partial cyst healing, one for recurrence) and 56.25% (9/16; one for surgical complication, eight for implant removal). Surgical intervention is indicated for selected patients with SBCs. Even though perfect functional results were possible with open curettage and grafting, continuous intramedullary decompression with elastic nails led to a higher radiographic healing rate in the treatment of humeral SBCs. Open curettage and grafting with or without intramedullary nailing was associated with a high number of complications, but the rate of reoperation for complications was very low.Publication Metadata only A Comparison of Rubrics and Graded Category Rating Scales with Various Methods Regarding Raters' Reliability(EDAM, 2017) ULUMAN MERT, MÜGE; Dogan, C. Deha; Uluman, MugeThe aim of this study was to determine the extent at which graded-category rating scales and rubrics contribute to inter-rater reliability. The research was designed as a correlational study. Study group consisted of 82 students attending sixth grade and three writing course teachers in a private elementary school. A performance task was administered to students and student works were divided into two randomly. The teachers first conducted independent scoring on the works in group one by using the graded category rating scale, and then they scored the works in groups two with rubrics. Raters reliability was estimated by intraclass correlation coefficient, generalizability theory (G-theory) and many-facet Rasch model. The results indicated higher inter-rater reliability when graded category rating scale was used. Moreover qualitative data revealed that raters prefer using graded category rating scale in situations where they need to do quick scoring in short intervals. It is recommended that teachers use graded-category rating scale as a practical tool for quick scoring with the aim of determining student achievement with grades rather than giving detailed feedback.Publication Metadata only A COMPLETE DESIGN METHODOLOGY FOR LEAN IN-PLANT LOGISTICS TO ASSEMBLY LINE USING AD PRINCIPLES(UNIV CINCINNATI INDUSTRIAL ENGINEERING, 2019) Aglan, Canan; Durmusoglu, Mehmet BulentImplementation of lean philosophy has gained importance since it has achieved an outstanding success especially in production systems. Principles of lean production are different from traditional systems, where parts feeding and material handling activities are performed differently especially in small lot production. Integration and coordination of these activities increase the efficiency of lean systems. In this paper, a complete design for in-plant logistics activities is performed via Axiomatic Design (AD) principles. A four-step design methodology from parts line side presentation through in-plant vehicle routing is proposed. Proposed design methodology in AD aims to decrease the information requirement of assembly line in-plant logistics design. From practitioners' perspective, most important design steps are arranged and Functional Requirements (FRs) are emphasized. Based on the FRs, comprehensive list of Design Parameters (DPs) are defined and interactions are highlighted. Both FRs and DPs are supported with literature and practical applications. The relations between lean principles, DPs and lean tools are evaluated and the justification of the proposed design is shown. To the best of authors' knowledge, this study is the first attempt in an integrated design of in-plant logistics activities. The findings of the study also point out voids in the literature and shed light on future studies.Publication Open Access A Computer Program Development for a Garment's Pre-Cost Account Calculation in Apparel Industry(EGE UNIV, 2019-06-30) EREN, EMİNE RÜMEYSA; Eren, Emine Rumeysa; Pamuk, OktayThe minimum difference between the pre-cost and actual cost in the apparel sector is very important for the enterprises to sustain their profitability. The fact that the estimated unit cost calculation requirement is very frequent and continuous in an environment where competition is increasing rapidly increases the workload of enterprises. In order to be able to take orders, companies must calculate the pre-cost estimation as close as possible to the actual cost. At this stage, companies encounter problems in fabric cost estimation which has the largest share especially in product cost. In this study, a computer program, which will be used in both weaving and knit top clothing group, has been formed in order to lighten the loads of apparel companies on the pre-unit cost calculation. The interface of the computer program is formed in C # programming language using Visual Studio and DevExpress programs. The most important attribute of this program is that, it can calculate the product unit fabric quantity and marker efficiency by using only the product measurement table without the need of a model design department. In order to achieve this, equations were created in the area of calculation of product pattern areas. The program incorporates all cost components in a progressive calculation and consequently presents a product pre-cost report. The computer program was performed in two companies that work in the field of export of woven and knit top apparel in Izmir. The data obtained from the program were compared with the actual data from the companies.Publication Open Access A decision support system based on simulation for airline boarding problem(GAZI UNIV, FAC ENGINEERING ARCHITECTURE, 2019-06-21) ALABAŞ USLU, ÇİĞDEM; Azuz, Erol; Tatar, Tuba; Uslu, Cigdem AlabasTravelling by airplanes is an increasingly popular and preferred way of transportation. Due to the increasing demand, airplane companies aim to have highest profit and the best service to their passengers. Since airplanes make money just when they are on the air, flight frequency has to be increased. Preparation of the aircraft and taking passengers into aircraft is knows as passenger boarding which is one the crucial factor to decrease turn-over time. The most appropriate way to prepare aircraft and taking passengers into aircraft within possible minimum time may yield enormous profit for airplane companies. Decrement in the duration of boarding process also has a positive impact on passenger satisfaction. In this study, a Decision Support System (DSS) has been developed to help generation and evaluation new boarding methods. DSS calculates mean interferences for new boarding methods created by user and compares these methods in terms of the number of interferences. Also, in this study two different boarding methods have been suggested and tested by using developed DSS. Tests showed that either suggested methods have less mean interferences than the other methods which are available in the literature or they are simpler and more realistic to apply into real-life.Publication Open Access A large Turkish pedigree with multiple endocrine neoplasia type 1 syndrome carrying a rare mutation: c.1680_1683 del TGAG(AVES, 2020-08-28) ÇETİN, ALİ; Demirtas, Coskun Ozer; Ata, Pinar; Cetin, Ali; Turkyilmaz, Ayberk; Duman, Deniz GuneyBackground/Aims: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome characterized by tumors arising from endocrine glands with no specific genotype-phenotype correlation. Here, we report the largest Turkish kindred with MEN1 syndrome which inherited a scarce MEN1 mutation gene. Materials and Methods: A 64-year-old man, referred to our gastroenterology outpatient clinic for evaluation of a pancreatic mass lesion, was diagnosed with MEN1 syndrome after endoscopic ultrasound-guided sampling of the mass revealed pancreatic neuroendocrine tumor (pNET) and accompanying primary hyperparathyroidism (PHPT) and pituitary tumor. Genetic analysis by whole gene Sanger sequencing of the MEN1 gene identified a frame-shift mutation in exon 10 (c.1680_1683delTGAG). All the relatives of the index case were proposed for clinical and genetic evaluation for MEN1 syndrome. Results: Of the 25 relatives of the index case, 17 were diagnosed with the MEN1 syndrome. Eighteen members among all relatives consented to genetic analysis, and 11 had the same mutation as the index case. All the mutation positive members had MEN1, while none of mutation-negative subjects had any sign of MEN1 syndrome. The frequencies of PHPT, pNET, and pituitary tumors in this kindred were 94.1% (16/17), 29.4% (5/17), and 29.4% (5/17) respectively. Conclusion: We report a rare MEN1 gene mutation which has been descibed in a single sporadic patient earlier. It was inherited by at least three generations of a large family, proving the strong dominant effect of the MEN1 phenotype. Further research may be conducted to clarify potential candidacy of this mutation as a hotspot for MEN1 patients, especially in the Turkish population.Publication Metadata only A link between PKR, inflammasome and synaptic plasticity:Is it an emerging therapeutic option for cognitive dysfunction?(TURKISH ASSOC PSYCHOPHARMACOLOGY, 2020) Guden, Demet Sinem; Aricioglu, FeyzaA cognitive decline biomarker candidate, RNA-dependent protein kinase R (PKR), is proposed to play a crucial role on inflammation, and psychiatric disorders through prolonged metabolic stress, cellular and molecular imbalance by regulating central cellular processes including mRNA translation, transcriptional control, apoptosis, and cell proliferation. PKR is an interferon-induced serine/threonine protein kinase and a well-known master regulator of protein synthesis via phosphorylating the translation initiation factor alpha (eIF2 alpha). Inflammasome assembly consists of large multiprotein complexes that are activated by the pathogen or damage-associated signals resulting in the formation of proinflammatory cytokines such as interleukin-1 beta (IL-1 beta), IL-18, and high-mobility group box 1 (HMGB1) protein. Release of pro-inflammatory cytokines and chemokines triggered by the host's innate immune response against harmful pathogens coordinated by inflammasomes. PKR and inflammasomes have share similar function including innate immunity and defense against viruses. The upstream molecular mechanisms underlying the regulation of inflammasome activation poorly identified. Here, we focused on the role of PKR on the regulation of inflammasome assembly formation by summarizing current investigations that are linked to inflammation/neuroinflammation-driven synaptic plasticity. Virus, inflammatory, and toxic cellular signals activate this protein kinase and then it initiates translation blockade via its downstream target. PKR activation also contributes to inflammation and immune dysfunction through the regulation of inflammatory cell signaling pathways. Cytokines regulated by inflammasomes are critical mediators of psychiatric diseases and neurodegenerative disorders. Previous works have suggested that systemic inflammation could contribute to neuroinflammation and related neurodegeneration via activation of inflammasome assembly. Previous researches found that PKR physically interacted with different inflammasomes. Recent investigations highlighted a key role for PKR in the regulation of inflammasome-mediated diseases and cognitive function. PKR might be a valid target to modulate neuroinflammation and neurodegeneration by modulating inflammasomes. Hence, it is conceivable to hypothesize that PKR could be a pharmacologically alluring objective for treating neuroinflammatory diseases by modulating inflammasome activation in parallel with learning and memory deficits. In the future, the assessment of this kinase levels in blood of patients would enable us to find novel biomarkers to struggle neuroinflammatory process in neurodegenerative and psychiatric diseases.Publication Open Access A METHOD FOR DYEING POLYESTER FIBRES WITH QUINONE DERIVATIVES AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY(ASSOC CHEMICAL ENG, 2018) Sayil, Cigdem; Deniz, Nahide Gulsah; Oner, Erhan; Koc, Damla; Ozyurek, Mustafa; Guclu, KubilayIn this study, a series of bis(thio) substituted-1,4-naphthoquinone compounds (4a-j) were synthesized via Michael addition reaction and their structures were determined by infrared spectrometry, H-1 and C-13 nuclear magnetic resonance spectroscopy, mass spectrometry and elemental analysis. The synthesized substances were applied to polyester fibers and the dyeing properties were investigated. The rubbing fastness, wash fastness and optical properties of synthesized compounds were also studied. The color change and staining test results were found to be 4 to 4-5 for the most of the dyed samples. There is only a small number of previous studies interested with dyeing properties of synthetic derivatives of heteroatom-substituted-1,4-naphthoquinone compounds in existing literature. The synthesized dyes were screened for their antioxidant activity, using the CUPRAC method against trolox (TR) as the standard reference compound at room temperature. The aims of this study were the synthesis of the quinone compounds, the investigation of the capability of dyeing polyester fibers and the evaluation of their antioxidant capacity, using the CUPRAC method. The dyed polyester fibers are promising candidates for biologically active fabrics to be used in various ways. We were encouraged to do this study in order to determine the dying properties and antioxidant activities of the quinone compounds.Publication Open Access A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience(GALENOS YAYINCILIK, 2019-07-22) Cekdemir, Demet; Guvenc, Serkan; Ozdemirkiran, Fusun; Eser, Ali; Topts, Tayfur; Ozkocaman, Vildan; Sahin, Handan Haydaroglu; Turak, Esra Ermis; Esen, Ramazan; Comert, Melda; Sadrilo, Sevil; Aslaner, Muzeyyen; Ulu, Bahar Uncu; Karakus, Abdullah; Bapur, Derya Selim; Alacacioglu, Inci; Aydin, Demet; Tekinalp, Atakan; Namdaroglu, Sinem; Ceran, Funda; Tarkun, Pinar; Kiper, Demet; Cetiner, Mustafa; Yenerel, Mustafa; Demir, Ahmet Muzaffer; Yilmaz, Guven; Terzi, Hatice; Atilla, Erden; Malkan, Umit Yavuz; Acar, Kadir; Ozturk, Erman; Tombak, Anil; Sunu, Cenk; Salim, Ozan; Alayvaz, Nevin; Sayan, Ozkan; Ozan, Ulku; Ayer, Mesut; Gokgoz, Zafer; Andic, Neslihan; Kizilkilic, Ebru; Noyan, Figen; Ozen, Mehmet; Tanrikulu, Funda Pepedil; Alanoglu, Guchan; Ozkan, Hasan Atilla; Aslan, Vahap; Cetin, Guven; Erikci, Alev Akyol; Deveci, Burak; Dursun, Fadime Ersoy; Dermenci, Hasan; Aytan, Pelin; Gunduz, Mehmet; Karakus, Volkan; Ozlu, Can; Demircioglu, Sinan; Yanar, Olga Meltem Akay; Ozatli, Duzgun; Undar, Levent; Tiftik, Eyup Naci; Sucak, EAyhan Gulsan Turkoz; Haznedaroglu, Ibrahim; Ozcan, Muhit; Sencan, Mehmet; Tombuloglu, Murat; Ozet, Gulsum; Bilgir, Oktay; Turgut, Burhan; Ozcan, Mehmet Ali; Payzin, Kadriye Bahriye; Sonmez, Mehmet; Ayyildiz, EOrhan; Dal, Mehmet Sinan; Ertop, Sehmus; Turgut, Mehmet; Soysal, Teoman; Kaya, Emin; Unal, Ali; Pehlivan, Mustafa; Atagunduz, Isik; Firatli, Tulin Tuglular; Saydam, Guray; Kucukkaya, Reyhan DizObjective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods: A total of 285 chronic ITP patients (187 women, 65.6 %; 98 men, 34.4%) followed in 55 centers were enrolled in this retrospective cohort. Response to treatment was assessed according to platelet count (/mm(3)) and defined as complete (platelet count of >100,000/mm(3)), partial (30,000-100,000/mm(3) or doubling of platelet count after treatment), or unresponsive (<30,000/mm(3)). Clinical findings, descriptive features, response to treatment, and side effects were recorded. Correlations between descriptive, clinical, and hematological parameters were analyzed. Results: The median age at diagnosis was 43.9 +/- 20.6 (range: 3-95) years and the duration of follow-up was 18.0 +/- 6.4 (range: 6-28.2) months. Overall response rate was 86.7% (n=247). Complete and partial responses were observed in 182 (63.8%) and 65 (22.8%) patients, respectively. Thirty-eight patients (13.4%) did not respond to eltrombopag treatment. For patients above 60 years old (n=68), overall response rate was 89.7% (n=61), and for those above 80 years old (n=12), overall response rate was 83% (n=10). Considering thrombocyte count before treatment, eltrombopag significantly increased platelet count at the 1st, 2nd, 3rd, 4th, and 8th weeks of treatment. As the time required for partial or complete response increased, response to treatment was significantly reduced. The time to reach the maximum platelet levels after treatment was quite variable (1-202 weeks). Notably, the higher the maximum platelet count after eltrombopag treatment, the more likely that side effects would occur. The most common side effects were headache (21.6%), weakness (13.7%), hepatotoxicity (11.8%), and thrombosis (5.9%). Conclusion: Results of the current study imply that eltrombopag is an effective therapeutic option even in elderly patients with chronic ITP. However, patients must be closely monitored for response and side effects during treatment. Since both response and side effects may be variable throughout the follow-up period, patients should be evaluated dynamically, especially in terms of thrombotic risk factors.