Person: ELBASAN, ONUR
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ELBASAN
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ONUR
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Publication Open Access Evaluation of sarcopenia in patients with hyperthyroidism(2022-12-01) TUFAN ÇİNÇİN, ASLI; ENGİN, EBRU; ELBASAN, ONUR; ILGIN, CAN; TUFAN ÇİNÇİN A., Engin E., Elbasan O., Durmus N. S., Can B., Ilgin C., Can B.Background and aim: Sarcopenia is a generalized skeletal muscle disease and thyroid hormones have regulatory effects on skeletal muscle metabolism. This study aims to evaluate the association between hyperthyroidism and sarcopenia. Methods: Thirteen patients with overt hyperthyroidism (OH), 13 patients with subclinical hyperthyroidism (SH) and 30 healthy volunteers were included. OH was defined as serum thyroid-stimulating hormone (TSH) 1.12 ng/dL and/or free T3 (fT3) >4.37 ng/L; while SH was defined as TSH <0.34 when fT4 and fT3 were within the normal reference range (0.61-1.12 ng/dL for fT4; 2.6-4.37 ng/L for fT3). Handgrip strength (HGS) measurement and chair stand test were performed for muscle strength, while skeletal muscle mass index measurement with bioelectrical impedance analysis and calf circumference (CC) measurement were performed for muscle mass evaluation. Results: The median age was 44.9 (21-76), and 16 (61.5%) were female. HGS and CC were found to be significantly lower in the OH and SH groups than in the control group (p=0.007; p=0.008, respectively). Sarcopenia was more common in the OH and SH groups than in the control group (p=0.007), and the risk of sarcopenia was higher in the OH group than in the SH group (OR: 2.44, 95% CI: 0.26-31.87). In hyperthyroid patients, a high fT4 increased the possibility of sarcopenia (OR: 6.0 95% CI: 0.59-79.23). Conclusions: Sarcopenia is significantly more common in patients with hyperthyroidism.Publication Metadata only Hyperandrogenism-related metabolic changes in drug-naïve transmen compared to cisgender women: a case-controlled study(2023-01-01) EREL, PINAR; ELBASAN, ONUR; YORGUNER, NEŞE; İMRE, EREN; ÜSTAY, ÖZLEM; EREL P., ELBASAN O., Yorguner N., İmre E., ÜSTAY Ö.Introduction: The aetiology of gender dysphoria is still unclear. Although prior studies have shown that trans men have higher androgen levels than cisgender women, they all concluded unselected populations. Our reason for performing this study is to evaluate trans men’s hormone profile and metabolic status to compare with cisgender women in a more selected population. This is the first case-controlled study to compare anthropometric, metabolic, and endocrinological parameters of drug-naïve trans men with those of cisgender women. Material and methods: We designed this study as a single-centre observational cohort study. We included 70 drug-naïve trans men, and the control group comprised 34 healthy cisgender women. We measured and compared hormone profiles and metabolic parameters in the 2 groups. Results: Of the 70 trans men individuals, 16 (22.85%) met the Rotterdam criteria and were diagnosed with polycystic ovary syndrome (PCOS); 4 individuals in the control group met the criteria (11.7%). Although we matched body mass index in the groups, total testosterone, free androgen index, androstenedione, 17 hydroxyprogesterone, muscle strength, triglyceride, and homeostatic model assessment of insulin resistance levels were significantly higher in the trans men than in the cisgender women (p < 0.05). Even after were excluded PCOS patients, hyperandrogenaemia was apparent in the trans men. Conclusion: Our study showed that trans men have clearly higher androgen levels, which may have been the reason for metabolic changes compared to cisgender women. However, the main reason for hyperandrogenism in drug-naïve trans men is still not known, and more comprehensive studies are needed.Publication Open Access Accurate interpretation of thyroid dysfunction during pregnancy: should we continue to use published guidelines instead of population-based gestation-specific reference intervals for the thyroid-stimulating hormone (TSH)?(2022-03-01) TURAN, CEM ARMAĞAN; ELBASAN, ONUR; ÜNLÜ, OZAN; TEKİN, AHMET FARUK; ŞİRİKÇİ, ÖNDER; GÖZÜ, HÜLYA; HAKLAR, GONCAGÜL; ESİM BÜYÜKBAYRAK, ESRA; Turkal R., TURAN C. A., ELBASAN O., Aytan S., Cakmak B., Gozaydinoglu B., Takir D. C., ÜNLÜ O., Bahramzada G., Tekin A. F., et al.Background Considering the changes in thyroid physiology associated with pregnancy and poor outcomes related to abnormal maternal thyroid function, international guidelines recommend using population-based trimester-specific reference intervals (RIs) for thyroid testing. If these RIs are not available in the laboratory, implementing recommended fixed cut-off values globally is still controversial. To address this issue, we aimed to establish appropriate RI of thyroid-stimulating hormone (TSH) in pregnant Turkish women for our laboratory and compare the prevalence of thyroid dysfunction based on the established and recommended criteria. Methods Of 2638 pregnant women, 1777 women followed in the obstetric outpatient were enrolled in the reference interval study after applying exclusion criteria related to medical and prenatal history. A retrospective study was conducted by collecting data from July 2016 to March 2019. Serum TSH was measured by UniCel DxI 800 Immunoassay System (Beckman Coulter Inc., Brea, CA, USA). The study design relied on two approaches in order to classify pregnant women: trimester-specific and subgroup-specific; the latter involved dividing each trimester into two subgroups: T1(a), T1(b), T2(a), T2(b), T3(a), T3(b). The lower and upper limits of the RIs were derived by the parametric method after normalizing the data distribution using the modified Box-Cox power transformation method. Results The lowest TSH value was detected at 8-12 weeks in early pregnancy, and the median value of TSH in the T1(b) subgroup was significantly lower than the T1(a) subgroup (P < 0.05). TSH levels showed a gradual trend of increase along with the pregnancy and increased significantly in the T2(a), T2(b,) and T3(b) subgroups compared to the preceding subgroups (P < 0.05). Compared to the diagnostic criteria recommended by American Thyroid Association (ATA), the prevalence of thyroid dysfunction was significantly different from the established trimester- and subgroup-specific RIs throughout the pregnancy (P < 0.001). Conclusions We conclude that establishing gestation- and laboratory-specific RIs, especially for TSH, is essential for diagnosing thyroid disorders in pregnancy, and the recommended universal cut-off values, which may contribute to the risk of a misdiagnosis or a missed diagnosis, should be taken with caution in the clinical setting. However, regarding the fluctuation of thyroid function tests throughout pregnancy, trimester-specific RIs are insufficient, and implementing split phases is required.Publication Metadata only Hormon naif transerkeklerde endokrin bozucu etkilerin Tiyometoksam, Fipronil ve Bisfenol-A düzeyleri ile incelenmesi: tek merkez vaka control çalışma(2022-05-19) ÜSTAY, ÖZLEM; ELBASAN, ONUR; Üstay Ö., Elbasan O., Erel P.İlaç naif transerkeklerde Bisfenol-A ve pestisit düzeyleri kontrol grubu ile karşılaştırıldığında istatistiki olarak fark saptanamamıştır