Person: EMRE, GİZEM
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EMRE
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GİZEM
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Publication Metadata only Medicinal and wild food plants of Marmara Island (Balikesir - Turkey)(POLSKIE TOWARZYSTWO BOTANICZNE, 2016) EMRE, GİZEM; Bulut, GizemMedicinal and wild food plants have always played an important role in people's lives especially in rural areas. Similar situation can be said for islands due to the reason of them being isolated from mainland. This paper reports an ethnobotanical investigations performed in 2009 and 2014 to determine medicinal and wild food plants of Marmara Island. A total of 30 individuals were interviewed (19 men, 11 women). Totally, 22 plants are recorded as used as traditional folk medicine for the region, and nine of these are also used as a source of wild food. Furthermore, 18 taxa are wild sources of nutrition for the area. The plants most commonly used in the region as medicinal remedies were Salvia fruticosa, Hypericum perforatum, Ficus carica, and Mentha spicata. Plants are mostly used for the treatment of abdominal pain, the common cold, and haemorrhoids. The species most commonly used for food are: Salvia fruticosa, Arbutus unedo, Rhus coriaria, and Rubus sanctus. This ethnobotanical study conducted in this island will enable the traditional use of wild plants both as food sources and herbal remedies to be passed on to future generations.Publication Metadata only In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz-An endemic folk medicinal plant(ELSEVIER SCI LTD, 2018) EMRE, GİZEM; Zengin, Gokhan; Bulut, Gizem; Mollica, Adriano; Picot-Allain, Carene Marie Nancy; Mahomoodally, Mohamad FawziCentaurea saligna (K.Koch) Wagenitz is an endemic plant used in Turkish folk medicine as antibacterial, tonic, astringent, choleretic, anti-rheumatic, diuretic, and antipyretic. This study attempts for the first time to assess the possible enzyme inhibitory potential, antioxidant activity, and determine the phytochemical profile of the ethyl acetate, methanol, and water extracts of C. saligna. The water extract had the highest phenolic content (30.18 mg GAE/g extract) and the most potent oxidant scavenging activity ((120.53, 111.90, 68.43, and 157.88 mg TEN extract, for CUPRAC [cupric reducing antioxidant capacity], FRAP [ferric reducing antioxidant power], DPPH [2,2-dipheny1-1-picrylhydrazyl], and ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid] assays respectively)). The water extract (4.16 mg KAE/g extract) also inhibited tyrosinase and contained high level of catechin (214 mu g/g extract). Ethyl acetate extract showed potent inhibitory capacity against cholinesterases (2.22 and 2.21 mg GALAE/g extract for acetyl and butyryl cholinesterase, respectively) and alpha-glucosidase (23.80 mmol ACAE/g extract). High concentration of apigenin (2472 mu/g extract) was identified in the ethyl acetate extract. In silico studies showed that apigenin binds to the enzymatic pocket of alpha-glucosidase and is stabilised by a network of hydrogen bonds and pi-pi stacking. Data collected in the present study advocates the need for further investigation geared towards validation of C. saligna for the management of complications related to the target enzymes, such as diabetes type II, Alzheimer's disease, and epidermal hyperpigmentation. (C) 2018 Elsevier Ltd. All rights reserved.Publication Metadata only Chemical composition and bio-functional perspectives of Erica arborea L. extracts obtained by different extraction techniques: Innovative insights(ELSEVIER, 2019) DOĞAN, AHMET; Zengin, Gokhan; Cvetanovic, Aleksandra; Gasic, Uros; Stupar, Alena; Bulut, Gizem; Senkardes, Ismail; Dogan, Ahmet; Seebaluck-Sandoram, Roumita; Rengasamy, Kannan R. R.; Sinan, Kouadio Ibrahime; Mahomoodally, Mohamad FawziErica arborea L., also known as Estrella Gold, is traditionally used for several purposes. In this research, five different extraction techniques: accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), maceration (MAC), soxhlet (SOE) and ultrasound-assisted extraction (UAE) were used to compare the total phenolic, flavonoids, total antioxidant activity and enzymatic activities of E. arborea extracts obtained different extraction techniques. The total phenolic and flavonoid contents were in the order of ASE > MAE > SOE > MAC > UAE. All extracts showed antioxidant, anticholinesterase, anti-tyrosinase and anti-diabetic activities. A highly sensitive method using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS) has been used for the qualitative analysis of obtained extracts. Seventy-two polyphenolic compounds were identified in all extracts. However, 20 components were quantified among the extracts. ASE was found to be a better extraction technique as compared to the other extraction techniques. E. arborea can be exploited in the discovery of bioactive natural products for the treatment of Alzheimer's disease, diabetes and pigmentation problems.Publication Metadata only THERAPEUTIC POTENTIAL OF MYRTUS COMMUNIS SUBSP COMMUNIS EXTRACT AGAINST ACETIC ACID-INDUCED COLONIC INFLAMMATION IN RATS(WILEY, 2017) ŞEN, ALİ; Sen, Ali; Yuksel, Meral; Bulut, Gizem; Bitis, Leyla; Ercan, Feriha; Ozyilmaz-Yay, Nagehan; Akbulut, Ozben; Cobanoglu, Hamit; Ozkan, Sevil; Sener, GokselThe aim of this study was to evaluate the effect of ethanol extract from leaves of Myrtus communis subsp. communis (MC) on acetic acid (AA)-induced ulcerative colitis in rats. On the fourth day of colitis induction, all rats were decapitated. Colitis was assessed by macroscopic and microscopic scores and by measuring malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol, lucigenin, nitric oxid and peroxynitrite chemiluminescence (CL). Colitis caused significant increases in the colonic MDA levels, MPO activity, CL values, macroscopic and microscopic damage scores along with significant decrease in tissue GSH level. However, treatment with MC extract reversed all these biochemical indices, as well as histopathological alterations induced by AA with the protective effects being similar to that of sulphasalazine treatment. The study showed that MC extract could alleviate colitis in rats and can be considered an alternative therapeutic approach for management of inflammatory bowel diseases (IBD).Publication Metadata only Gümüşi ıhlamur (Tilia tomentosa Moench.) çiçek durumu standardizasyonunda kullanılan farmakognozik yöntemler(2020-02-01) EMRE, GİZEM; GÜZELMERİÇ E., Yüksel P. I., BULUT G., YEŞİLADA E.Ihlamur çiçek durumu, Tilia (ıhlamur) cinsinin çiçekleri ve braktesinden oluşur. Ihlamur, sahip olduğu farmakolojik etkilerinden (örn. sedatif, spazmolitik, anti-enflamatuvar, ekspektoran) dolayı yüzyıllardır halk ilacı olarak kullanılmaktadır. Sağlığa yararlı etkileri içerdiği flavonoit (tilirozit, astragalin, izokersitrin, hiperozit vb.), müsilaj, uçucu yağ (1,8-sineol, timol, karvakrol, benzaldehit vb.), kafeik asit, klorojenik asit gibi maddelerden ileri gelmektedir. Tıbbi olarak T. cordata Miller (küçük yapraklı ıhlamur) ve T. platyphyllos Scop. (büyük yapraklı ıhlamur) türleri çeşitli farmakopelerde (örn. Avrupa Farmakopesi) yer almaktadır. Ancak, bu türler Türkiye’de ya doğal olarak yetişmez (T. cordata) ya da nadiren (T. platyphyllos) bulunur. Buna karşın, ülkemizde Tilia rubra DC. (Kafkas ıhlamuru) Karadeniz Bölgesi’nde, Tilia tomentosa Moench. (sin. Tilia argentea Desf.) ise Marmara Bölgesi’nde bolca yetişir. T. tomentosa yapraklarının alt yüzeyinde beyazımsı yıldız tüyler taşıması sebebiyle gümüşi ıhlamur olarak adlandırılır. Tıbbi türlerin az yetişmesi nedeniyle, Türkiye’de halk ilacı olarak bolca yetişen T. rubra ve T. tomentosa türleri sıklıkla kullanılır. Ancak, bu iki tür de Avrupa Farmakopesi’nde yer almamaktadır. Bu çalışmada, T. cordata, T. platyphyllos ve T. cordata, T. platyphyllos ve T. vulgaris karışımı (tıbbi türler) ile Marmara Bölgesi’nin farklı yerlerinden toplanan T. tomentosa örnekleri kıyaslanarak Türk Farmakopesi’nde yer alması önerilen ‘Gümüşi ıhlamur çiçek durumu’ monografı hazırlanması hedeflenmiştir.Publication Metadata only HPLC-MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata(ELSEVIER SCIENCE BV, 2018) DOĞAN, AHMET; Zengin, Gokhan; Diuzheva, Alina; Jeko, Jozsef; Cziaky, Zoltan; Bulut, Gizem; Dogan, Ahmet; Haznedaroglu, Mehmet Zeki; Rengasamy, Kannan R. R.; Lobine, Devina; Bahadori, Mir Babak; Mahomoodally, Mohamad FawziArnelanchierparviflora var. dentata is an endemic medicinal plant traditionally consumed to treat stomach pain, cardiovascular diseases, and urinary tract infections in Turkey's folk medicine. Although Amelanchier genus is an excellent source of phytochemicals with a panoply of biological activities, no report has been made available on Amelanchier parviflora var. dentata. Thus, the metabolic profiles of methanol, ethyl acetate, and water extracts were obtained using HPLC-MS/MS. Besides, the pharmacological properties such as antioxidant activity and enzyme inhibition effects against acetyl/butyrylcholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase were evaluated. In total, 62, 38, and 16 metabolites were Identified from the methanolic, water, and ethyl acetate extracts, respectively. The identified metabolites belong to anthocyanins, phenolic acids, and flavonoids. The tested extracts exhibited different enzyme inhibitory activity against cholinesterases (acetylcholinesterase: 0.52-2.47 mg GEs/g extract and butyrylcholinesterase: 0.47-3.59 mg GEs/g extract), tyrosinase (19,0-145.54 mg KAEs/g extract), alpha-amylase (0.23-1.10 mmol ACEs/g extract), and alpha-glucosidase (8.89-9.92 mmol ACEs/ g extract). Evidence from the present study supports the necessity for more research in an endeavor to discover biologically active secondary metabolites from A. parviflora to manage specific ailments.Publication Metadata only The folk-medicinal plants of Kadisehri (Yozgat - Turkey)(POLSKIE TOWARZYSTWO BOTANICZNE, 2015) EMRE, GİZEM; Han, Muhammed Ihsan; Bulut, GizemThis paper contains significant ethnobotanical information on folk-medicinal plants and their ethnopharmacological uses in Kadisehri. The aim of the study was mainly to collect and identify the plants used therapeutically by the local people, and to make available information about traditional herbal medicine. It was undertaken during the period 2011-2012 and is based on plants collected during field work. Fifty-six plants used in folk-medicine and belonging to 34 families were identified in this study. Of these, 48 species were wild, and 8 species were cultivated plants. The most common families were Rosaceae (12.5%), Lamiaceae (8.9%) and Asteraceae (7.1%); and the most common preparations were decoctions (36.7%). In addition, a cultural importance index (CI) and use report (UR) were calculated for each species. Based on the CI, the most important plants were Cydonia oblonga (0.77), Ecballium elaterium (0.66), Urtica urens (0.66), Vitis vinifera (0.66), Plantago lanceolata (0.65), Plantago major subsp. major (0.65) and Rosa canina (0.62). We found three species of plant (Astragalus noaeanus, Populus xcanescens and Salvia cyanescens) which had never before been reported to have medicinal properties.Publication Metadata only Özel monograflar(sağlık bakanlığı türkiye ilaç ve tıbbi cihaz kurumu, 2020-06-01) EMRE, GİZEM; Emre G.Publication Metadata only Investigation of antioxidant and antibicrobial activities of muscari armeniacum(2023-05-04) RAYAMAN, ERKAN; YILMAZ, BEYZA NUR; EMRE, GİZEM; TAŞKIN, TURGUT; Avcı E., Rayaman E., Yılmaz B. N., Emre G., Taşkın T.Publication Metadata only Paeonia arietina and Paeonia kesrounansis bioactive constituents: NMR, LC-DAD-MS fingerprinting and in vitro assays(ELSEVIER SCIENCE BV, 2019) DOĞAN, AHMET; Sut, Stefania; Zengin, Gokhan; Dall'Acqua, Stefano; Gazdova, Marketa; Smejkal, Karel; Bulut, Gizem; Dogan, Ahmet; Haznedaroglu, Mehmet Zeki; Aumeeruddy, Muhammad Zakariyyah; Maggi, Filippo; Mahomoodally, Mohamad FawziPaeonia species have been valued for their ethnomedicinal uses in various countries and received much interest among the scientific community for their therapeutic properties, including anti-microbial, anti-inflammatory, anti-cancer, nephroprotective and hepatoprotective effects. The multiple phytother-apeutical applications of Paeonia species inspired us to establish the phytochemical fingerprint and to evaluate the biological properties of ethyl acetate, methanol, and aqueous extracts from the roots and aerial parts of two Paeonia species (P. arietina G. Anderson and P. kesrounansis Thiebaut). Phytoconstituents of P. arietina and P. kesrounansis extracts were analyzed using 1D and 2D NMR and LC-DAD-ESI-MS. The total content of phenolics (TPC) and flavonoids (TFC) in the extracts was also evaluated. The antioxidant activity was profiled using DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelation assays. Enzyme inhibitory properties were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, alpha-amylase, and alpha-glucosidase. Phytochemical analysis of P. arietina and P. kesrounansis extracts showed the presence of galloyl esters of sugars, galloyl monoterpenes, and glycosylated flavonoids. The three solvent extracts presented different behavior in the bioassays. The highest antioxidant activity, tyrosinase and AChE inhibition were observed for the methanolic extract of the aerial parts of P. kesrounansis. In addition, the ethyl acetate extracts of the aerial parts of both plants were the most effective inhibitors of alpha-amylase. The highest BChE inhibition was observed for root methanolic extract of P. kesrounansis while the root ethyl acetate extract of P. arietina exerted the strongest inhibition of alpha-glucosidase. Methanol extract of P. kesrounansis aerial parts presented the highest TPC, while TFC was greatest in the corresponding extract of P. arietina. Our findings can be considered as a starting point for future studies to further validate the effectiveness and safety profiles of these plants in folk medicine. (C) 2018 Elsevier B.V. All rights reserved.