Person: AĞRALI, ÖMER BİRKAN
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AĞRALI
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ÖMER BİRKAN
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Publication Open Access Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study(MDPI, 2020-03-01) YILMAZ GÖLER, AYŞE MİNE; Kavuncu, Gamze; Yilmaz, Ayse Mine; Yilmaz, Betul Karademir; Atali, Pinar Yilmaz; Altunok, Elif Cigdem; Kuru, Leyla; Agrali, Omer BirkanThe aim of this study is to determine the cytotoxicity of three different nano composite resins (CRs) on human gingival fibroblast (hGF) and periodontal ligament fibroblast (hPDLF) cell lines. These CRs selected were nanohybrid organic monomer-based Admira Fusion (AF), nanohybrid Bis-(acryloyloxymethyl) tricyclo [5.2.1.0.sup.2,6] decane-based Charisma Topaz (CT), and supra nano filled resin-based Estelite Quick Sigma (EQS). MTT assay was performed to assess the cytotoxicity of CRs at 24 h and one week. AF and EQS applied on hGF cells at 24 h and one week demonstrated similar cytotoxic outcomes. Cytotoxicity of CT on hGF cells at one week was higher than 24 h (p = 0.04). Cytotoxicity of CT on hGF cells was higher at 24 h (p = 0.002) and one week (p = 0.009) compared to control. All composites showed higher cytotoxicity on hPDLF cells at one week than the 24 h (AF; p = 0.02, CT; p = 0.02, EQS; p = 0.04). AF and EQS demonstrated lower cytotoxicity on hPDLF cells than the control group at 24 h (AF; p = 0.01, EQS; p = 0.001). CT was found more cytotoxic on hPDLF cells than the control (p = 0.01) and EQS group (p = 0.008) at one week. The cytotoxicity of CRs on hGF and hPDLF cells vary, according to the type of composites, cell types, and exposure time.Publication Metadata only Evaluation of gingival crevicular fluid transforming growth factor-1 level after treatment of intrabony periodontal defects with enamel matrix derivatives and autogenous bone graft: A randomized controlled clinical trial(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) YARAT, AYŞEN; Agrali, O. B.; Kuru, B. E.; Yarat, A.; Kuru, L.Aim: The present study aimed to evaluate the effects of enamel matrix derivatives (EMD) either alone or combined with autogenous bone graft (ABG) applied to intrabony defects in chronic periodontitis patients on clinical/radiographic parameters and gingival crevicular fluid (GCF) transforming growth factor-1 (TGF-1) level and to compare with open flap debridement (OFD). Materials and Methods: A total of 30 deep intrabony defects in 12 patients were randomly treated with EMD + ABG (combination group), EMD alone (EMD group), or OFD (control group). Clinical parameters, including plaque index, gingival index, bleeding on probing, probing depth, relative attachment level, and recession were recorded at baseline and 6 months postsurgery. Intrabony defect fill percentage was calculated on the standardized radiographs. TGF-1 level was evaluated in GCF just before surgery and 7, 14, 30, 90, 180 days after surgery using enzyme-linked immunosorbent assay. Results: All treatment procedures led to significant improvements at 6 months (P 0.01). Gain in attachment level (P 0.01) and radiographic defect fill (P 0.05) of the combination and EMD groups were found to be significantly higher than those of the control group, while the use of EMD either with ABG or alone was observed to produce significantly less recession than the OFD (P 0.05). Conclusion: The findings suggest no clinical and radiographic differences between the combination and EMD groups whereas GCF TGF-1 level demonstrates an increase during the healing phase and is positively affected from EMD.Publication Open Access Peri-implantitis and Severity Level(2020-02) KURU, LEYLA; Elemek, Eser; Agrali, Omer Birkan; Kuru, Bahar; Kuru, LeylaAbstract Objectives Different diagnostic criteria were used for diagnosis of peri-implant diseases. The aim of this cross-sectional study was to explore prevalence of peri-implant diseases and subclassify peri-implantitis based on different levels of radiographic and clinical findings. Materials and Methods Two hundred patients having 655 dental implants were included in this study. In addition to clinical measurements, standard long-cone parallel technique was used to evaluate marginal bone level around implants. Following diagnosis of peri-implant diseases, peri-implantitis was further subclassified using a severity leveling in terms of marginal bone level and probing depth. Results Mean age of 200 subjects was 52.8 ± 12.2 years and 63% were females. In total, bleeding on probing was present in 93% and suppuration in 27% of implants. On subject basis, 2.5% were diagnosed as healthy, 28% with peri-implant mucositis (PM), and 69.5% with peri-implantitis, whereas on implant basis, 3.6% were healthy, 36% presented PM, and 60.4% peri-implantitis. Furthermore, when severity leveling was applied, peri-implantitis prevalence changed markedly and ranged from 14.5 to 31.0% at the subject level and from 10.0 to 22.0% at the implant level. Subgingival restoration margins were observed in 70.6% of patients for implants with PM and in 44% patients for implants with peri-implantitis. Most of the implants with peri-implantitis were with platform match (71.5%). Conclusions Applying different thresholds to the peri-implantitis definition yielded different prevalence rates ranging from 10 to 31%. As no established diagnostic criteria are being used today, results from clinical studies may not reflect the true disease prevalence.Publication Open Access Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects(HINDAWI LTD, 2018-06-28) ÖZBEYLİ, DİLEK; Agrali, Omer B.; Yildirim, Selin; Ozener, Hafize O.; Kose, Kemal N.; Ozbeyli, Dilek; Soluk-Tekkesin, Merva; Kuru, LeylaHyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats. In the same rats, the other defect was treated with HA matrix alone. One of the 2 defects formed in other 8 rats was treated with HA + G and the other with HA + M. One of the 2 defects formed in the remaining 8 rats was treated wilh G+M and the other with HA+G+M. The animals were sacrificed at 4 weeks. Histologic, histomorphometric, and immunohistochemical analyses were performed. Both HA matrix alone and its combinalions with G and M supported new bone formation (NBF). However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P < 0.00l). Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them. Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.Publication Metadata only Do Platform Switching Together with Subcrestal Placement have a Benefit on Marginal Bone Levels Around Dental Implants?(AVES PRESS LTD, 2018) KURU, LEYLA; Agrali, Omer Birkan; Elemek, Eser; Dincer, Janberd; Kigili, Ahmet; Cilingir, Altug; Kuru, Leyla; Almas, KhalidObjective: The aim of this retrospective study was to assess the marginal bone levels around platform-switched dental implants placed subcrestally in partially or totally edentulous patients who had been treated in a private practice. Methods: A total of 200 implants placed in 64 patients, with a mean follow-up time of 5.3 +/- 1.7 years, were included in the study. Implants were placed 0.5 mm subcrestally via one-or two-stage surgical approach. Data regarding the distribution and diameter of the implants, the type of the prosthetic restoration, and marginal bone levels were assessed by one calibrated examiner. Results: Overall, the mean marginal bone loss was found to be 0.82 +/- 1.6 mm, and 66% of the implants (n=81) showed no bone loss, whereas 28% (n=35) showed bone loss >1mm, and 20% (n=25) showed bone loss >2mm. Out of 18 implants in use for 1-3 years, 14 of them showed no bone loss. Among implants that were in function for 3-5 years, 25% (n=15) showed bone loss >1mm, and 12% (n=7) showed bone loss >2mm. In this study, the majority of the implants were in use for more than 5 years (n=122). Out of them, 66% (n=81) showed no bone loss, whereas 28% (n=35) showed bone loss >1 mm, and 20% (n=25) showed bone loss >2mm. Conclusion: Within the limits of this retrospective study, one can say that slight amount of marginal bone loss is observed around the platform-switched implants placed subcrestally in a long-term follow-up. However, further studies are needed to confirm this finding.Publication Open Access Treatment of lateral periodontal cyst with guided tissue regeneration(2014-07) KURU, LEYLA; Meseli, Suleyman Emre; Agrali, Omer Birkan; Peker, Onder; Kuru, LeylaABSTRACT Lateral periodontal cyst (LPC), originated from epithelial rests in the periodontal ligament, is a noninflammatory cyst on the lateral surface of the root of a vital tooth. LPC is generally asymptomatic and presents a round or oval uniform lucency with well-defined borders radiographically. In this case report, clinical, histological and radiographical findings and periodontal treatment of 32-year-old female patient, who was referred to Department of Periodontology Clinic of Faculty of Dentistry, Marmara University with a painless hyperplastic lesion on the distobuccal site of the tooth number 12, were presented. The tooth number 12 was vital and a well-defined round radiolucent area with corticated borders was determined radiographically. Preliminary diagnosis was LPC based on clinical and radiographical findings. Mechanical periodontal treatment consisted of oral hygiene instructions, scaling and root planing was applied and flap operation was performed to gain access to the lesion. Following enucleation of the lesion, alveolar bone destruction shaped as a tunnel from labial to palatinal site was observed. The bone cavity was grafted with bovine-derived xenograft, followed by placement of a resorbable collagen membrane. Tissues removed from of the lesion were examined histologically. Hematoxylen-eosin stained sections showed vasculature granulomatous structure underlying squamous epithelium, and destructed bone spaces, all of which were consisted with LPC. Acceptable clinical healing was achieved at 6 months follow-up period. Satisfactory clinical and radiographical outcome can be achieved in the treatment of LPC using regenerative periodontal approach.Publication Metadata only Peri-implant Tissues and Diseases(MARMARA UNIV, INST HEALTH SCIENCES, 2017) YILDIRIM, HATİCE SELİN; Elemek, Eser; Agrali, Omer Birkan; Yildirim, Hatice Selin; Kuru, LeylaPeri-implant diseases occur due to imbalance between host response and biofilm after successful osseointegration of an implant with the bone. Among peri-implant diseases, peri-implant mucositis is used to describe the presence of inflammation only within the mucosa, whereas peri-implantitis is characterized by loss of supporting bone in addition to the inflammation within the mucosa. For the diagnosis of peri-implant diseases, probing depth, bleeding on probing, and suppuration are clinically assessed. Additionally, supporting bone levels are radiographically evaluated. Smoking, lack of oral hygiene, history of periodontal disease, diabetes mellitus, cardiovascular diseases, and implant surface characteristics are the known risk factors for the development of peri-implant diseases. For the treatment of peri-implant mucositis, antimicrobial treatment is performed together with mechanical debridement. However, these treatment approaches are not sufficient for peri-implantitis cases. For the treatment of peri-implantitis, resective and/or regenerative surgical interventions are used in addition to mechanical debridement. It is crucial to improve the knowledge among dentists about the prevention and progression of peri-implant diseases. On the other hand, patients should be advised regular dental visits and to maintain the highest level of oral hygiene.Publication Metadata only The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020) YILDIRIM, HATİCE SELİN; Kose, K. N.; Yilmaz, S.; Noyan, U.; Kuru, B.; Yildirim, H. S.; Agrali, O. B.; Ozener, H. O.; Kuru, L.Background: Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO). The growth factors may have a role in the pathogenesis of amlodipine-induced GO. Objectives: This pilot study aimed to investigate the growth factors including transforming growth factor-b1 (TGF-b1), platelet-derived growth factor-BB (PDGF-BB), and basic fibroblast growth factor (bFGF) in gingival crevicular fluid (GCF) of patients with amlodipine-induced GO and compare with of healthy subjects. Methods: GCF samples were collected from 56 sites presenting GO (GO + group) and from 38 sites not presenting GO (GO- group) of 5 patients using amlodipine for more than one year, and from 45 sites (control group) of 5 healthy subjects. The levels of TGF-b1, PDGF-BB, and bFGF were determined by using ELISA kits. Results: The mean concentration of TGF-b1 in GCF samples of GO + group (9.50 +/- 7.30 ng/ml) was higher than both GO- group (2.07 +/- 0.50 ng/ml) and control group (2.74 +/- 1.01 ng/ml) (P = 0.014). No significant difference was found among the groups in the GCF levels of PDGF-BB (P = 0.767). bFGF was detected in only 33% of the sites from patients. Conclusion: These preliminary results suggest that TGF-b1 may play a crucial role in the pathogenesis of amlodipine-induced GO.Publication Metadata only Extra- and Intraoral Clinical Findings of Recessive Dystrophic Epidermolysis Bullosa: A Case Report(AVES PRESS LTD, 2016) NAMDAR PEKİNER, FİLİZ MEDİHA; Meseli, Suleyman Emre; Agrali, Omer Birkan; Pekiner, Filiz Namdar; Kuru, LeylaEpidermolysis bullosa (EB) is a heterogeneous group of inherited blistering mucocutaneous disorders that have a specific defect in the attachment mechanisms of the epithelial cells, either to each other or to the underlying connective tissue. Recessive dystrophic type EB (Hallopeau-Siemens syndrome) represents repeated episodes of cutaneous breakdown, which heal with scarring, resulting in the fusion of the fingers into a mitten-like deformity. The vesicle/bulla can be intraorally observed and the depth of the buccal vestibule may decrease because of scarring. In this case report, the intra-/extraoral findings of a 25-year-old male patient, who was diagnosed with recessive dystrophic type EB immediately after birth, are presented. Extraoral examination revealed mitten-like hands and feet because of scar tissue formations on the hands and feet. Similarly, during intraoral examination, scar tissue formations were observed that had caused denuded mouth opening and limited tongue functions. In addition, periodontal problems and dental caries were observed because of limited plaque control. This case report emphasizes the importance of knowledge regarding patients with EB and presents some intraoral findings.Publication Metadata only Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats(2023-09-01) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.