Person: CÜCÜ, AYŞEN
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CÜCÜ
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AYŞEN
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Publication Metadata only İmhası istenilen ürünler(2015-12-01) CÜCÜ, AYŞEN; BİTİŞ, LEYLA; RAYAMAN, ERKAN; ŞAHBAZ, SEVİNÇ; AKGÜN ÖLMEZ, SEVCAN GÜL; Cücü A., Bitiş L., Rayaman E., Şahbaz S., Akgün Ölmez S. G.Publication Open Access Determination and stability of some international screening limited drugs in equine blood by LC-MS/MS(ANKARA UNIV PRESS, 2019-10-01) CÜCÜ, AYŞEN; Goktas, Eylem Funda; Kabil, Erol; Gunes, Ertugrul; Korkmaz, Serol; Kadioglu, Tuba Asena; Cucu, Aysen KurtStability of some international screening limited therapeutic substances for doping control in equine blood has been investigated with a validated method by using LC-MS/MS after chemical hydrolysis with orthophosphoric acid. Whole blood samples were extracted with a WAX cartridge on auto-SPE. Stability test of the drug substances performed at the same time in working solution and matrix at +4 degrees C, -20 degrees C, +20 degrees C in dark and +20 degrees C in light conditions for 1, 2, 3 and 4 weeks. For short-time stability, the effects of 6 h storage at +55 degrees C was also investigated. Repeated data were statistically analyzed with ANOVA. All substances in working solution were stable at -20 degrees C and +4 degrees C. In the blood matrix, higher temperatures (+20 degrees C) in light and dark caused degradation of substances at the end of four weeks and short-term study (P<0.05). In conclusion, these international screening limited substances in blood matrix could be unstable related to temperature and storage time, although in working solution they could be mostly stable in various temperatures for four weeks.Publication Open Access Quantitative Determination of The Heavy Metals (Lead, Zinc And Manganese) in White Cheese Produced in Ergene Basin by Using Atomic Absorption Spectrophotometry(MARMARA UNIV, FAC PHARMACY, 2015-04-09) CÜCÜ, AYŞEN; Cucu, Aysen Kurt; Yavuz, Mustafa; Demir, Hulya DemircanIt is well known that heavy metals are harmful for human health appearing only after exceeding the specific concentrations of each metal. This study was carried out to determine the concentrations of heavy metals in cheese that was produced in diaries of Ergene Basin. The dairies near the Ergene River were investigated and suitable ones were selected. Since the sampling process directly affects the sensitivity of the results, particular attention was given to this process. A total of twelve samples of cheese were collected from different diaries and each samples were digested three times by dry ashing and wet ashing methods and totally 108 cheese samples were obtained for metal analyses. The lead, manganese content of the cheese samples were measured by graphite furnace atomic absorption spectrophotometer and zinc content of the cheese samples were measured by flame atomic absorption spectrophotometer. Contents of heavy metals in the examined samples were compared with the excepted limit values in the literature and the results were evaluated. Experimental data shows that the concentrations of heavy metals are in the range of accepted limit values.Publication Open Access İstanbul Aktarlarında Satılan Bitkisel Çaylarda Ağır Metal Tayini(2015-04-17) CÜCÜ, AYŞENPublication Metadata only Potentiometric studies of mixed complexes of Cobalt(II) and Copper(II) with L-asparagine and adenine(Gordon and Breach Science Publishers, 1999) CÜCÜ, AYŞEN; Demir H.D., Pekin M., Cücü A.K., Dölen E., Aboul-Enein H.Y.A potentiometric titration technique has been used to determine the stability constants for the various complexes of Co(II) and Cu(II) with L-asparagine and from DNA base, e.g. adenine. Stability constants of ternary systems have been evaluated by the method suggested by Irwing-Rossotti. In addition, the conditional constants were calculated as a function of pH. The maximum values of the conditional formation constants were found to be in accordance with the mixed-ligand complex formation constants in a determined pH region. Furthermore, the molar fractions of different species from mixed complexes were calculated by means of formation constants. The values of stability constants of mixed-ligand complexes at 25°C are as follows: log K = 5.25 for Co(II)-L-asparagine-adenine; log K = 9.30 for Cu(II)-L-asparagine-adenine. The ionic strength was kept constant at I = 0.20 with NaClO4.Publication Metadata only Quantitative Determination of Heavy Metal Contamination in Horse Mackerel and Whiting Caught in the Sea of Marmara(SPRINGER, 2019) CÜCÜ, AYŞEN; Cucu, Aysen Kurt; Topkaya, Murat; Erdogan, Gulbin; Aboul-Enein, Hassan Y.In this study, the concentrations of lead, cadmium and manganese were determined in horse mackerel (Trachurus mediterraneus) and whiting (Merlangius merlangus euxinus) that were caught in the Sea of Marmara. These are commonly consumed fish species in this region. Fish were provided by a fishermen quarterly between March 2013 and December 2013 and, separated according to size (small, medium and large). Pb(II), Cd(II) and Mn(II) levels were determined using the wet digestion method by Graphite furnace atomic atomic absorption spectrophotometer. According to this study, for horse mackerel, the highest concentration of lead, cadmium, and manganese was 6.69 A mu g kg(-1) (September), 5.24 A mu g kg(-1) (March) and 9.24 A mu g kg(-1) (June), respectively. For whiting, the highest concentration of lead, cadmium, and manganese was 2.25 A mu g kg(-1) (June), 0.263 A mu g kg(-1) (September) and 10.4 A mu g kg(-1) (June), respectively. These heavy metal levels in fish were found to be acceptable for human consumption according to World Health Organization border values.Publication Metadata only The Determination of the Stability Constant of Finasteride Complexes with Various Metals by Potentiometric and Spectrophotometric Methods(MARMARA UNIV, FAC MEDICINE, 2016) CÜCÜ, AYŞEN; Cucu, Aysen Kurt; Arslan, Emine; Karaderi, SerapIn this study, the stability constants of the cobalt(II), zinc(II), cadmium(II) and copper(II) complexes of finasteride were determined potentiometrically by using Irving-Rossotti and Calvin-Bjerrum methods and supported by spectrophotometric way [1-3]. The evaluated protonation constant of finasteride was found as logK=2,21. Potentiometrically the logarithms of the stability constants of the finasteride-metal complexes were found by Calvin-Bjerrum and Irving-Rossotti methods: for cobalt(II) complex logK=3,01; for zinc(II) complex logK=2,82; for cadmium(II) complex logK=3,04 and for copper complex logK=2,85 at 25 degrees C (I=0,10). Conditional formation constants of the complexes were calculated and pH ranges of the complexation were found. Spectrometric measurements were recorded for cobalt(II)finasteride, zinc(II)-finasteride, cadmium(II)-finasteride and copper(II)-finasteride solutions and the results of the measurement supported the formation of complexes. In this study, the stability constant of finasteride complexes with metals were determined using the potentiometric and spectrophotometric methods. These metals can be received directly or indirectly to the human body. Therefore, the stability constants that we found, can shed light on the analysis of blood samples of patients.Publication Metadata only Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation(ELSEVIER SCIENCE BV, 2006) CÜCÜ, AYŞEN; Demir, H; Cucu, A; Sakarya, SA quantitative method for finasteride by liquid chromatography (LC) with UV detector, was validated for its new tablet form Dilaprost (R). Analysis was performed using Nova Pak C-18 column at 60 degrees C. Detection was carried out at a wavelength of 210 nm. The best separation for finasteride peak was achieved by isocratic elution with the mobile phase water/acetonitrile/tetrahydrofuran (80/10/10, v/v/v) and flow rate of 2 mL min(-1). The sample volume injected into liquid chromatography system was 15 mu L. Analytical method validation tests were performed. (c) 2005 Elsevier B.V. All rights reserved.