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EKİNCİ, GAZANFER

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Author: TÜRKDOĞAN, DİLŞAD × Has files: false ×

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    Anti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase
    (SAGE PUBLICATIONS INC, 2014) TÜRKDOĞAN, DİLŞAD; Turkdogan, Dilsad; Orengul, A. Cahid; Zaimoglu, Sennur; Ekinci, Gazanfer
    Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is an autoimmune/paraneoplastic encephalitis, with neurologic and psychiatric symptoms. Early and aggressive therapy has been shown to improve prognosis although problems with executive functions and memory have continued for several years. A 15-year-old girl had a history of initial symptoms including behavioral difficulties, poor attention, and frequent seizures progressing to a catatonia-like state, 2.5 months after onset of initial symptoms. Anti-NMDA receptor antibodies were detected in serum and cerebrospinal fluid. Subsequent to treatment with methylprednisolone starting 3 months after onset, motor skills, responsiveness, self-care, and speech improved rapidly. Her neuropsychologica profile assessed after 2 months showed global difficulties predominantly in attention, executive functions, memory, and visual perception, which moderately recovered in the 7th and 24th months, respectively. Contrary to current literature supporting the positive impact of early immunomodulatory therapy, a dramatic resolution of major neurologic and psychiatric symptoms was detected with steroid treatment given in the late phase.
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    Global aphasia without hemiparesis may be caused by blunt head trauma: An adolescent boy with transient aphasia
    (ELSEVIER SCI LTD, 2017) TÜRKDOĞAN, DİLŞAD; Sahin, Sevim; Turkdogan, Dilsad; Hacifazlioglu, Nilufer Eldes; Yalcin, Emek Uyur; Eksen, Zehra Yilmaz; Ekinci, Gazanfer
    Global aphasia without hemiparesis is a rare condition often associated with embolic stroke. Posttraumatic causes have not been reported, in the literature, to our knowledge. We report a 15-year old boy with transient global aphasia without hemiparesis due to blunt head trauma. In our case, clinical findings occurred 1 week later following head trauma. Emergence of the symptoms after a period of the first mechanical head trauma, draws attention to the importance of secondary process in traumatic brain injury. (C) 2016 Elsevier Ltd. All rights reserved.