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EKİNCİ, GAZANFER

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EKİNCİ

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GAZANFER

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Now showing 1 - 4 of 4
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    Intractable seizure with hypoglycemia: A mysterious retroperitoneal fibrosarcoma
    (2022-01-01) MİDİ, İPEK; EKİNCİ, GAZANFER; MİDİ İ., Okay B. B. , Cetin S. Z. , EKİNCİ G.
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    Cervical-Intracranial Atherosclerosis and Serum Uric Acid Level Association in Acute Stroke
    (GAZI UNIV, FAC MED, 2020-03-01) EKİNCİ, GAZANFER; Suer, Devran; Midi, Ipek; Ekinci, Gazanfer
    Objective: We aimed to identify whether high uric acid levels were associated with atherosclerotic intracranial/extracranial arterial stenosis and atrial fibrillation (AF) and to determine if serum uric acid (SUA) levels were an independent risk factor. Methods: One hundred seventy-four patients who presented with acute stroke within 24 hours of onset and were admitted to our hospital between December 2016 and September 2017 were included in the study. Bamford classification was used for Stroke classification. The degree of vascular stenosis was classified as lumen contour irregularity, mild, moderate and severe stenosis using the The North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria. Results: The average age of 174 patients was 69 +/- 12.7 years. Elevated serum uric acid levels were found in 66 patients. The mean SUA level was 7.33 +/- 1.02 mg/dL in these patients. Thirty-six patients were examined with AF and 14 of these patients had high SUA levels. It was found that high SUA levels were mostly related with lacunar infarct (LACI) and partial anterior circulation infarct (PACI), respectively. High SUA levels were seen more commonly in the anterior circulation, especially in the extracranial part of the carotid artery, but this was not statistically significant (p>0.05). We found a statistically significant relation between high SUA levels in moderate and severe stenosis of the extracranial portion of the posterior circulation in women (p=0.01). There was a relationship between atrial fibrillation and extracranial atherosclerosis of the anterior circulation as contour irregularity and moderate stenosis (p=0.05). Conclusions: In our study, it was found that high SUA levels were related to LACI and PACI, respectively. Further studies with larger groups are needed.
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    Stress-induced childhood onset neurodegeneration with ataxia and seizures (condsias) presenting with torticollis attacks: phenotypic variability of the same mutation in two turkish patients
    (2022-03-01) ÖZTÜRK THOMAS, GÜLTEN; ÜNVER, OLCAY; AKBEYAZ, İSMAİL HAKKI; EKİNCİ, GAZANFER; TÜRKDOĞAN, DİLŞAD; Ozturk G., Ayaz A., Topcu Y., Akyuz G., ÜNVER O., AKBEYAZ İ. H. , EKİNCİ G., TÜRKDOĞAN D.
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    Prognostic factors in progressive high-grade glial tumors treated with systemic approach: A single center experience
    (SAGE PUBLICATIONS LTD, 2021) ATASOY, BESTE MELEK; Alan, Ozkan; Telli, Tugba Akin; Tuylu, Tugba Basoglu; Arikan, Rukiye; Demircan, Nazim Can; Ercelep, Ozlem; Kaya, Serap; Babacan, Nalan Akgul; Atasoy, Beste M.; Bozkurt, Suheyla; Bayri, Yasar; Gul, Dilek; Ekinci, Gazanfer; Ziyal, Ibrahim; Dane, Faysal; Yumuk, P. Fulden
    Purpose Malignant high-grade gliomas are the most common and aggressive type of primary brain tumor, and the prognosis is generally extremely poor. In this retrospective study, we analyzed the outcome of systemic treatment in recurrent high-grade glioma patients and the impact of prognostic factors on survivals. Methods Data from 114 patients with recurrent high-grade glioma who received systemic treatment and followed in our clinic between 2012 and 2018 were retrospectively analyzed. Eastern Cooperative Oncology Group (ECOG) performance status, age, gender, histology, type of surgical resection, side effects after systemic treatment (deep vein thrombosis, hypertension, proteinuria), IDH1 and alpha thalassemia/mental retardation syndrome X-linked (ATRX) mutation status were investigated as prognostic factors for progression-free survival and overall survival. Results At the time of diagnosis, the median age was 48 (17-77) and 68% of the patients were male. Most common pathologic subtype was glioblastoma multiforme (68%). Median follow-up duration was 9.1 months (1-68 months). Median progression-free survival and overall survival were 6.2 months and 8 months, respectively. In multivariate analysis, ECOG PS, deep venous thrombosis and the presence of ATRX and IDH1 mutation were found to be independent prognostic factors for progression-free survival (p < 0.05) and, ECOG PS, the presence of ATRX and IDH1 mutation for overall survival (p < 0.05). Conclusion Our study is real life data and the median progression-free survival and overall survival rates are similar to the literature. We have found ECOG PS, presence of ATRX and IDH1 mutation to be independent prognostic factors for both progression-free survival and overall survival.