Person: ALPAY, HARİKA
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ALPAY
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HARİKA
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Publication Open Access Is renal abscess still a problem?(MARMARA UNIV, FAC MEDICINE, 2021-01-26) ALPAY, HARİKA; Sak, Mehtap; Gokce, Ibrahim; Cicek, Neslihan; Guven, Sercin; Ergelen, Rabia; Yildiz, Nurdan; Alpay, HarikaRenal abscess, the accumulation of infected fluid in the kidney, is a rare condition seen in children as well as adults. It leads to long term hospital admission and antibiotic use. Early diagnosis is an important factor in the outcome of renal abscess because the management may differ. Urinalysis test results and radiologic imaging findings of the patients who are admitted to hospital with complaints of fever, vomiting, abdominal pain or flank pain are important for the early diagnosis. Undertreated cases have high risk for renal scar formation. In this paper, we aim to present three pediatric patients, who showed the complication of renal abscess and were treated with long term antibiotic use without a need for surgical drainage.Publication Metadata only Renal artery stenosis and aneurysm in a child presenting with hypokalemia, metabolic alkalosis and hypertension [Hipokalemi, metabolik alkaloz ve hipertansiyon ile bavuran bir çocukta renal arter darliǧi ve anevrizmas](Turkish Society of Nephrology, 2016) ALPAY, HARİKA; Gökce I., Bölükbaş B.F., Buǧur I., Güven S., Deniz N.Ç., Altuntaş Ü., Yildiz N., Ergelen R., Baltacioǧlu F., Alpay H.Renovascular hypertension is one of the important causes of secondary hypertension in children and can be caused by many different diseases, with the most common being fibromuscular dysplasia (FMD) and Takayasu arteritis (TA). The differential diagnosis between TA and FMD seems to be difficult and much less certain than is generally assumed in many cases. Here we present a case report of an 11-yearold girl with FMD presenting with hypokalemia, metabolic alkalosis and hypertension secondary to renal artery stenosis and hyperreninemic hyperaldosteronism.Publication Metadata only Paraoxonase 1 192 and 55 polymorphisms in nephrotic children(SPRINGER, 2006) ALPAY, HARİKA; Biyikli, NK; Alpay, H; Yildiz, N; Agachan, B; Ergen, A; Zeybek, U; Bozkurt, N; Ispir, THuman paraoxonase 1 (PON1) is a serum enzyme related to high-density lipoprotein which has a major role in preventing oxidative modification of low-density lipoprotein. Due to its amino acid substitution PON1 has two genetic polymorphisms. These polymorphisms are characterized by the location of glutamine (A genotype) and arginine (B genotype) at position 192, and leucine (L genotype) and methionine (M genotype) at position 55. Hyperlipidemia and increased lipid oxidation in nephrotic syndrome may lead to glomerulosclerosis and progression of the glomerular disease. In this study we aimed to investigate PON1 192 and PON1 55 polymorphisms in children with focal segmental glomerulosclerosis (FSGS) and control subjects. The study included 25 children with biopsy-proven FSGS and 30 healthy controls. We demonstrated a statistically significant difference between FSGS patients and control subjects with respect to the distribution of the PON1 polymorphism. The AA genotype was less frequent and the AB+BB genotype was more frequent in FSGS patients than in controls (48 versus 73% for AA genotype and 52 versus 27% for AB+BB genotype, p < 0.05). Distributions of PON1 55 genotypes of FSGS and control subjects were also statistically different (76 versus 43% for LL genotype and 24 versus 57% for LM+MM genotype, p < 0.05) (case-control study, dominant model, Fisher's exact test). The distributions of both genotypes in subgroups of FSGS (stable renal function versus declining renal function) were not statistically different. We conclude in this preliminary study that presence of B allele and/or L allele may be risk factors for the development of FSGS in children.Publication Metadata only Çok nadir görülen bir olgu: üç üreter ve VUR(2018-05-03) ÇİÇEK DENİZ, NESLİHAN; YILDIZ, NURDAN; ALPAY, HARİKA; Tugtepe H., canmemiş a., ÇİÇEK N., YILDIZ N., ALPAY H., dağlı t.Publication Metadata only Henoch schönlein purpurası kliniği ile başvuran sistemik lupus eritematozis olgusu(2020-02-20) YILDIZ, NURDAN; ALPAY, HARİKA; İrem A., Bodur Demirci E., Pul S., ÇİÇEK N., GÜVEN S., YILDIZ N., Gökçe İ., ALPAY H.Publication Open Access Serum leptin concentration in children with chronic renal failure(DR BEHCET UZ COCUK HASTALIKLARI VE CERRAHISI, 2018) ALPAY, HARİKA; Atas Berksoy, Emel; Alpay, Harika; Yildiz, Nurdan; User, YasemenObjective: Various factors are responsible for uremic anorexia. Increase in serum leptin levels and uremic toxins stimulate melanocortin hormone receptors to increase energy consumption and reduce food intake. In this study, we investigated renal excretion of leptin by comparing serum leptin concentrations of healthy controls, and children with chronic renal failure.& para;& para;Methods: Serum leptin, leptin / BMI, albumin, glucose, creatinine, urea, triglyceride and cholesterol levels were eveluated in a total of 33 pediatric patients followed up for chronic renal failure and 29 healthy children in the control group.& para;& para;Results: Serum leptin levels (18.49 +/- 28.55) and leptin / BMI (0.94 +/- 1.36) in female patients were higher than leptin (7.73 +/- 5.65) and leptin / BMI (0.39 +/- 0.25) in the control group (p>0.05). In male patients, serum leptin levels (1.48 +/- 1.36; 4.88 +/- 3.70) and leptin/ BMI (0.08 +/- 0.081; 0.25 +/--0.16) were found to be lower than those of the control group (p<0.01). Serum leptin levels showed a significant positive correlation with BMI in female patients with chronic renal failure and, healthy women; whilethere was no correlation between leptin and BMI in the male patient group. There was no correlation between leptin and glomerular filtration rate and serum creatinine levels in all patients excepting male dialysis patients. There was no correlation between serum leptin levels and age, time to disease diagnosis, and duration of dialysis.& para;& para;Conclusion: Lack of any correlation between serum leptin levels, and renal functions, and detection of significantly lower serum leptin concentrations in male children with renal failure relative to healthy male children suggest that there might be other factors involved in the synthesis, activity or extrarenal clearance of leptin or its receptor proteins.Publication Open Access Invasive aspergillosis in a patient with end stage renal disease(ELSEVIER SCIENCE BV, 2017-12) KEPENEKLİ KADAYİFCİ, EDA; Cicek, Neslihan; Yildiz, Nurdan; Kadayifci, Eda Kepenekli; Gokce, Ibrahim; Alpay, HarikaInvasive aspergillosis caused by A. Fumigatus, almost occurs in immunocompromised hosts and has a poor prognosis. We report a case of invasive Aspergillosis in a 15-year-old boy with ESRD. He was initially diagnosed as lobar pneumonia and peritonitis. When he complained for lower extremity weakness and had convulsions, a solid mass originated from right lung compresses the spinal cord and intracranial hemorrhagic abscesses were found on MRI. The biopsy specimen showed hypae of aspergillus-spp and he died on 12th day.Publication Metadata only Dent's disease in a child with nephrolithiasis [Nefrolityazis tanısıyla başvuran bir olguda dent hastalıǧı](Kare Publishing, 2013) ALPAY, HARİKA; Yildiz N., Deniz N.Ç., Altuntaş U., Gökçe I., Alpay H.[No abstract available]Publication Metadata only An unusual disease mimicking congenital nephrotic syndrome: Answers(SPRINGER, 2021) ALPAY, HARİKA; Yildiz, Nurdan; Sak, Mehtap; Inanir, Sabahat; Akkelle, Bilge Sahin; Alpay, HarikaPublication Metadata only Could neutrophıl-lymphocyte ratıo be used as a prognostıc factor ın hemolytıc uremıc syndrome?(2022-11-01) YILDIZ, NURDAN; BİLGÜN, CEREN; DEMİRCİ BODUR, ECE; GÖKCE, İBRAHİM; ALPAY, HARİKA; YILDIZ N., BİLGÜN C., Guven S., DEMİRCİ BODUR E., Cicek N., Pul S., Turkkan O. N. , GÖKCE İ., ALPAY H.