Person: CESUR, SÜMEYYE
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CESUR
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SÜMEYYE
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Publication Metadata only Keratin loaded pva/silk fibroin electrospun nanofibers for wound dressing applications(2022-11-26) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Tut T. A., Cesur S., Gündüz O.Publication Metadata only Fabrication and characterization of naringenin-loaded poly(lactic acid) (pla) nanofibrous scaffolds(2022-11-26) BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Erdağ Z., Yeşil E., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Fabrication, characterization and investigation of antibacterial activity of propolis substituted sodium alginate tissue scaffolds using three-dimensional (3d) printing technology(2021-06-05) UZUN, MUHAMMET; SU TORUN, SENA; ULAĞ, SONGÜL; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Aarancı K., Uzun M., Su Torun S., Cesur S., Ulağ S., Amin A., Güncü M. M., Aksu M. B., Kolaylı S., Silva J., et al.Publication Metadata only Development of Electrospun Nanofibers Containing Gentamicin and Cinnamaldehyde for Treating Corneal Infections(2023-06-30) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Tut T. A., Cesur S., Ilhan E., Gawrońska E. K., Gündüz O.Publication Metadata only Development of janus microbubbles with varied morphologies by the effect of different solvents(2022-11-26) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Yeşilyurt T., Cesur S., Üstündağ C. B., Gündüz O.Publication Metadata only Controlled release of donopezil-loaded polyvinyl alcohol (pva) microbubbles/nanoparticles using microfluidic t-junction device(2020-09-18) CESUR, SÜMEYYE; ÇAM, MUHAMMET EMİN; GÜNDÜZ, OĞUZHAN; Cesur S., Çam M. E., Gündüz O.Production of donepezil- loaded microbubble/nanoparticles for treatment of Alzheimer diseasePublication Metadata only Inula helenium extract-loaded nanofibrous patches for the treatment of cancer(2023-06-30) CESUR, SÜMEYYE; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; Sulutas R. B., Cesur S., Ayaz-Seyhan S., Bilğiç Alkaya D., Gündüz O.Publication Open Access Microfluidic systems for neural tissue engineering(Elsevier Science, Oxford/Amsterdam , 2023-01-01) CESUR, SÜMEYYE; ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Cesur S., Ulağ S., Gündüz O.Damage to the nervous system due to illness or injury can cause serious and lasting loss of function or even fatal consequences. It is necessary to develop new treatment strategies to restore the function of the damaged nervous system.The optimal environment for nerve cell proliferation and differentiation is provided by neural tissue engineering. It aims to improve a new approximation for the therapy of nervous system diseases. Compared to 2D cell culture techniques, 3D cell culture systems ensure a more biomimetic environment and encourage more differentiation of cells. However, certain cell culture parameters have limitations in spatio-temporal control. With the advent of microfluidic systems, it can control the spatio-temporal dispersion of physical and chemical signals at the cellular level. In this section, microfluidic systems are explored as a tool to target both physical and chemical injury and recreate the post-injury environment, to study nerve injury at the cellular grade.Publication Metadata only Design and Fabrication of Metformin-Loaded Tri-Layer PCL/PVA/PCL Scaffolds for Chronic Wound Healing(2022-06-24) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Harmancı S., Cesur S., Gündüz O., Üstündağ C. B.Chronic wounds occur when an acute wound cannot complete the normal wound healing process that takes 4-8 weeks. The recurrence rate of chronic wounds is 70% and is more common in people with diseases such as diabetes and obesity [1]. Therefore, healing chronic wounds is a very challenging and costly process. Chronic wounds have higher inflammation and reducing inflammation is a promising approach for healing these wounds [2]. Metformin is an antidiabetic drug used for the treatment of diabetes. However, the anti-inflammatory effect of metformin has recently attracted attention for its use in wound healing [3]. 3D-printed scaffolds mimic the extracellular matrix (ECM) to support cell attachment and proliferation at the wound healing site and these scaffolds could be loaded with drugs, growth factors, and other agents for increasing wound healing [4]. In this study, tri-layered PCL/PVA/PCL and PCL/PVA-Met/PCL scaffolds were produced by using an extrusion 3D printer for chronic wound healing. The characterization of the scaffolds was done with Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), and the tensile test machine. The average pore size of the PCL/PVA/PCL and PCL/PVA-Met/PCL scaffolds was 82,96±4,018 and 63,60±4,039 μm, respectively. Both scaffold's pore sizes were within a limit that allows skin regeneration. The FTIR and XRD results were in compromise with each other, demonstrating that Metformin was successfully encapsulated in the polymer solution. In vitro drug release of Metformin was analyzed with a UV spectrophotometer. The upper and lower PCL layer in the tri-layered structure provided sustained release of the drug. Less than 50% of the drug was released in 24 hours, but it reached 100% on day 31. The biocompatibility of the scaffolds was also investigated with the MTT test. The test showed that both scaffolds were non-toxic and these Metforminloaded tri-layered scaffolds could have a promising potential for the treatment of chronic wounds.Publication Metadata only Multilayer patches for the treatment of corneal perforations caused by infections(2022-09-28) CESUR, SÜMEYYE; TINAZ, GÜLGÜN; ŞENGÖR, MUSTAFA; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Kijeńska-Gawrońska ., İlhan E., Cesur S., Sulutaş R. B., Pilavcı E., Dalbayrak B., Kaya E., Arısan E. D., Tınaz G., Şengör M., et al.